Abstract: A method for treating depression in patients with depression and bipolar disorder who have not responded to antidepressants and to avoid dose dumping upon ingestion of alcohol. The present invention also relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

Abstract: The present invention relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

Abstract: The invention relates to a method of treatment using a solid oral pharmaceutical dosage form comprising an opioid receptor antagonist for use in the treatment of opioid induced constipation comprising the opioid antagonist equivalent to 24 mg of naloxone hydrochloride as twice daily formulation or equivalent to 48 mg of naloxone hydrochloride as once daily formulation, characterized in that the opioid antagonist has a rapid first pass metabolism with a plasma half-life of 2 hours or less in humans within the first 3 hours of oral administration of a solution, wherein the steady state pharmacokinetics result in a constant level of naloxone in the bloodstream, wherein the pharmacokinetics are independent of whether the dosage is administered once or twice daily, wherein the oral dosage form releases the opioid antagonist in a prolonged manner, wherein the in vitro release rate of the opioid antagonist measured using the paddle stirrer method according to Ph. Eur. at 75 rpm in 1000 ml 0.

Abstract: The present invention relates to a solid oral pharmaceutical composition comprising naloxone, or a pharmaceutical acceptable salt thereof, as an active substance, wherein the composition releases the active substance in a prolonged manner. In order to provide a composition that is suitable for an administration period of at least twelve-hours for the treatment of opioid-induced constipation, it is proposed that the composition should have an in vitro release rate of the active substance measured using the paddle stirrer method according to Ph. Eur. at 75 rpm in 500 ml 0.1 N hydrochloric acid at 37° C., of 0% to 75% in 2 h, of 3% to 95 % in 4 h, of 20% to 100% in 10 h, of 30% to 100% in 16 h, of 50% to 100% in 24 h, and of more than 80% in 36 h, wherein the composition has a IC50/Cmax value of at least 40. In an alternative embodiment, the composition can be a multilayer tablet.

Abstract: The present invention relates to a solid oral pharmaceutical composition comprising naloxone, or a pharmaceutically acceptable salt thereof, as an active substance, wherein the composition releases the active substance in a prolonged manner. In order to provide a composition that is suitable for an administration period of at least twelve-hours for the treatment of opioid-induced constipation, it is proposed that the composition should have an in vitro release rate of the active substance measured using the paddle stirrer method according to Ph. Eur. at 75 rpm in 500 ml 0.1 N hydrochloric acid at 37° C., of 0% to 75% in 2 h, of 3% to 95% in 4 h, of 20% to 100% in 10 h, of 30% to 100% in 16 h, of 50% to 100% in 24 h, and of more than 80% in 36 h, wherein the composition has a IC50/Cmax value of at least 40. In an alternative embodiment, the composition can be a multilayer tablet.

Abstract: The present invention relates to a controlled-release oral dosage form for administration of oxycodone once a day and a method of preparing a controlled-release oral dosage form for administration of oxycodone once a day.

Abstract: The present invention relates to a controlled-release oral dosage form for administration of oxycodone once a day and a method of preparing a controlled-release oral dosage form for administration of oxycodone once a day.

Abstract: The short hop communication link includes a sensor module positioned downhole from a motor in a well. The module includes sensors that monitor operational, directional and environmental parameters downhole and provide an electrical data signal indicative thereof. Sensors may also be positioned in the drill bit for obtaining parameters related to the bit, and communicating data signals reflecting the sensed parameters to the sensor module. The sensor module includes a transceiver, with an annular anrenna, for transmitting electromagnetic sensor data signals to a point above the motor. A control module, which also includes a transceiver with an annular antenna, is located above the motor, and receives the electromagnetic signals from the sensor module reflecting the sensed parameters. In addition, the control module is capable of transmitting command signals to the sensor module requesting data regarding desired parameters.

Abstract: The method and apparatus relies on a modified induction approach and preferably is incorporated into a metal drill collar for MWD measurements. Directional nulls are created in a primary changing magnetic field formed in a formation by a transmitting antenna which is in a groove on the surface of the drilling collar. Detecting antennas are placed at the directional nulls to enable the primary magnetic field to be decoupled from the same and allow it to be distinguished from the secondary field caused by the current induced in the formation by such primary field. The drill collar also carries a plurality of current detectors which detect the value of current induced in the formation to provide a resistivity profile immediately adjacent the borehole. A preferred embodiment uses a hybrid modified induction and electrical approach.

Abstract: A unipolar, RZ, constant width pulse telemetry is achieved in the combinatorial set, or any desired subset of pulse sequences thereof. Each input datum W is in one-to-one correspondence with a particular pulse sequence and the correspondence of datum with pulse sequence and vice versa is implemented by any selected ordering of the pulse sequences of the combinatorial set together with a successive comparison of the magnitude of the datum with the cumulative combinatorial capacity of the set.

Abstract: A modified subterranean antenna structure for use in boreholes that pivotally balances a separate core member within the hollow interior of a fixed winding member in order to filter out mechanically induced vibrations from the core. The mechanical natural resonant frequency of the core is reduced and becomes less than the lowest electromagnetic signal frequency intended to be transmitted to and received by the subterranean antenna. In this way, mechanically induced vibrations will not create mechanically generated frequency signals sympathetic to the frequencies chosen for the antenna communication band frequencies.

Abstract: A subsurface valve-actuator combination for well production tubing is described. The valve is urged to closed position but held open by a battery-operated latch of the actuator. A receiver-relay in the battery-actuator circuit maintains a switch closed to permit the latch to be energized as long as the receiver-relay receives an electromagnetic signal transmitted from the earth's surface. The latch is deenergized upon interruption of the signal and/or if the battery power is insufficient to energize the same.

Abstract: A modified subterranean antenna structure for use in boreholes that pivotally balances a separate core member within the hollow interior of a fixed winding member in order to filter out mechanically induced vibrations from the core. The mechanical natural resonant frequency of the core is reduced and becomes less than the lowest electromagnetic signal frequency intended to be transmitted to and received by the subterranean antenna. In this way, mechanically induced vibrations will not create mechanically generated frequency signals sympathetic to the frequencies chosen for the antenna communication band frequencies.

Abstract: A unipolar, RZ, constant width pulse telemetry is achieved in the combinatorial set, or any desired subset of pulse sequences thereof. Each input datum W is in one-to-one correspondence with a particular pulse sequence and the correspondence of datum with pulse sequence and vice versa is implemented by any selected ordering of the pulse sequences of the combinatorial set together with a successive comparison of the magnitude of the datum with the cumulative combinatorial capacity of the set.

Abstract: A subsurface valve-actuator combination for well production tubing is described. The valve is urged to closed position but held open by a battery-operated latch of the actuator. A receiver-relay in the battery-actuator circuit maintains a switch closed to permit the latch to be energized as long as the receiver-relay receives an electromagnetic signal transmitted from the earth's surface. The latch is deenergized upon interruption of the signal and/or if the battery power is insufficient to energize the same.

Abstract: A method and apparatus for stabilizing a communication sensor in a borehole is described. The principle embodiment described includes a pair of centralizers at opposite ends of the housing for the communication sensor to maintain each of such respective ends at a constant lateral displacement from the borehole casing. A pair of flexible joints are provided to isolate the communication sensor to decouple the component to be protected from any motion and/or forces secured to the same urging it from the centralized position.

Abstract: A unipolar, RZ, constant width pulse telemetry is achieved in the combinatorial set, or any desired subset of pulse sequences thereof. Each input datum W is in one-to-one correspondence with a particular pulse sequence and the correspondence of datum with pulse sequence and vice versa is implemented by any selected ordering of the pulse sequences of the combinatorial set together with a successive comparison of the magnitude of the datum with the cumulative combinatorial capacity of the set.

Abstract: A subsurface valve-actuator combination for well production tubing is described. The valve is urged to closed position but held open by a battery-operated latch of the actuator. A receiver-relay in the battery-actuator circuit maintains a switch closed to permit the latch to be energized as long as the receiver-relay receives an electromagnetic signal transmitted from the earth's surface. The latch is deenergized upon interruption of the signal and/or if the battery power is insufficient to energize the same.

Abstract: The location method uses relatively low frequency electromagnetic fields, e.g., 1-1000 Hz, for determining the relative position and/or orientation of a transmitting magnetic dipole antenna by using a vector field receiver. The transmitting antenna for subterranean location, is preferably a single axis, elongated solenoid with a ferromagnetic core. The receiving sensor may be a precise three-axis magnetic field detector of either a magnetometer or search coil type. Measurements are made for one or more positions of either the transmitter or receiver, or with one or more transmitters or receivers. The relative location of the transmitter and the receiver is calculated with respect to some known survey station by a method of successive approximations. The operating frequency is chosen to minimize field distortion from common steel structures, such as pipe, casing or railroad tracks, and to minimize field scattering such as from conducting inhomogeneities in the earth.

Abstract: For the directional drilling of boreholes, the orientation of accelerometer modules, magnetometer modules and gyroscopes or other directional sensing devices must be accurately known and maintained with respect to each other and to external mounting devices. This is accomplished by a self-aligning segmented cylindrical connection which accurately maintains modules in rotational alignment with each other for all three directions of rotation, even if the mating surfaces of the connection experience wear due to rough use in the drilling application or repeated calibration in a calibration fixture. Wedged surfaces on each of the male and female portions of the connection constitute the mating surfaces, and are the only surfaces at which the male and female portions contact one another. A depression between the mating surfaces defined by the female portion permits reproducible angular displacement of one portion with respect to the other even if one or both portions are worn.