Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.

Abstract: A shifting register, a driving method thereof, a driving circuit and a display device are provided. The shifting register includes a control circuit (10), a first output circuit (20), a second output circuit (30) and a first switching transistor (T1). Shifting output of signals may be realized through interaction of all of the circuits. Moreover, an influence of a leak current on a signal of a second end of the first switching transistor is reduced by setting the first switching transistor (T1) to isolate the second output circuit (30) and a second node (N2).

Abstract: Kits and methods for selecting a cell harboring a genome-editing event at a target sequence of interest are disclosed. One such kit comprises: (i) a first DNA editing agent for specifically introducing a mutation into a first gene so as to generate a first selection marker which imparts resistance to a selection agent, wherein the target sequence of interest the said first gene are distinct; and (ii) the selection agent; and/or (iii) a second DNA editing agent for specifically introducing a mutation into the first gene, wherein the mutation disrupts selection marker activity of the first selection marker.

Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.

Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises: a) at least one bilayer-forming lipid; b) a polymeric compound having the general formula I: wherein m, n, L, X, Y, and Z are as defined herein; and c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.

Abstract: A solar cell includes a semiconductor substrate, a conductive region disposed in or on the semiconductor substrate, and an electrode comprising a plurality of finger lines connected to the conductive region, and formed to extend in a first direction while being parallel, and 6 or more bus bar lines formed to extend in a second direction crossing the first direction.

Abstract: Methods, electronic devices, and storage media for driving an interaction object are provided. The methods include: obtaining an audio signal at a periphery of a display device; obtaining, based on the audio signal, first driving data for driving the interaction object to respond; monitoring, in response to outputting the first driving data, the audio signal for detecting a sound of a target object; and driving, based on a presence state of the sound of the target object in the audio signal, the interaction object to respond.

Abstract: An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug.

Abstract: A spin-selective conduction structure comprises a crystal having a monolayer of metal atoms between two layers of chiral organic molecules. Each metal atom is coupled to two chiral organic molecules, one at each layer, wherein a chirality of organic molecules in one of the two layers is the same as a chirality of organic molecules in another one of the two layers.

Abstract: A flashlight with lateral locking function for firearms, comprises: a flashlight body and a lateral locking mechanism, the lateral locking mechanism is used to fix the flashlight body to a firearm; the lateral locking mechanism comprises a bottom box and a connecting component, an adjustment component is arranged on the bottom box, the adjusting component is connected with the connecting component, and comprises an adjusting handle, the adjusting handle is connected with a side wall of the bottom box, using to drive the movement of the connecting component, so that the connecting component is connected or disconnected from the firearm. The disclosure realizes the quick installation and disassembly. The whole installation process does not need to use other tools such as wrenches, and the installation is firm; the adjusting handle is arranged on the side wall of the bottom box, which is convenient for users to operate.

Abstract: A method for reconstructing three-dimensional includes the following operations. At least two frames of first key images for current reconstruction are acquired. A first space surrounding visual cones of the at least two frames of the first key images is determined. The first key images are obtained by photographing a to-be-reconstructed target. A first feature map of the first space is determined based on image information in the several frames of the first key images. The first feature map includes first feature information of voxels in the first space. A first reconstruction result of the current reconstruction is obtained based on the first feature map. A second reconstruction result obtained by previous reconstruction is updated based on the first reconstruction result of the current reconstruction.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a computer-implemented method for displaying a heat map are provided. One of the methods includes: receiving heat data from a server, wherein the heat data comprises a color value associated with each of a plurality of regions and one or more geographic locations respectively corresponding to one or more boundary points of each of one or more heat regions among the plurality of regions; generating a first heat map comprising a plurality of pixels; obtaining a second heat map by adjusting the color value of each pixel in the first heat map; and providing the second heat map for display, wherein the second heat is superimposed on a digital map. This method addresses the issue of conventional techniques that service request information may be misrepresented due to abrupt changes in color values across neighboring heat regions.

Abstract: Provided is a method for preparing a diol. In the method, a saccharide and hydrogen as raw materials are contacted with a catalyst in water to prepare the diol. The employed catalyst is a composite catalyst comprised of a main catalyst and a cocatalyst, wherein the main catalyst is a water-insoluble acid-resistant alloy; and the cocatalyst is a soluble tungstate and/or soluble tungsten compound. The method uses an acid-resistant, inexpensive and stable alloy needless of a support as a main catalyst, and can guarantee a high yield of the diol in the case where the production cost is relatively low.

Abstract: This application discloses a data processing method and apparatus, an electronic device, and a storage medium. When execution is performed at an operation layer of a neural network model, based on a pre-stored buffer allocation relationship, a first address range for cyclic addressing is set for a first buffer corresponding to input data and a second address range for cyclic addressing is set for a second buffer corresponding to an output result. Subsequently, cyclic addressing can be performed in the first buffer based on the first address range for cyclic addressing, to read the input data for the operation layer; and cyclic addressing can be performed in the second buffer based on the second address range for cyclic addressing, to write the output result of the operation layer into the second buffer. In this way, efficiency of buffer utilization can be effectively improved, and further operation efficiency for the model is improved.

Abstract: Provided are an all-solid-state battery and a preparation method thereof. The all-solid-state battery includes a positive electrode, a negative electrode, and a solid-state electrolyte located between the positive electrode and the negative electrode. The negative electrode includes a first negative electrode and a second negative electrode. The second negative electrode is located on a side of the first negative electrode. The solid-state electrolyte includes a first solid-state electrolyte and a second solid-state electrolyte. The first solid-state electrolyte is located between the positive electrode and the first negative electrode. The second solid-state electrolyte is located between the positive electrode and the second negative electrode. The roughness of the second solid-state electrolyte is greater than the roughness of the first solid-state electrolyte.

Abstract: The present disclosure provides a quantum dot light emitting diode, a manufacturing method thereof and a display device, and belongs to the field of display technologies. The quantum dot light emitting diode of the present disclosure includes an anode layer, a cathode layer, a quantum dot layer disposed between the anode layer and the cathode layer, an electron transport layer disposed between the quantum dot layer and the cathode layer, and an electron blocking layer disposed between the electron transport layer and the quantum dot layer; and metal-sulfur bonds are formed in an interface between the electron blocking layer and the quantum dot layer, and contain metal elements from the quantum dot layer and sulfur elements from the electron blocking layer.

Abstract: The present disclosure relates to the technical field of display, and discloses a quantum dot light-emitting device and a preparation method thereof. The quantum dot light-emitting device includes a first electrode layer, a quantum dot light-emitting layer, an electron transport layer, a second electrode layer and a third electrode layer which are sequentially arranged in a stacked manner, wherein the side, facing away from the first electrode layer, of the third electrode layer is configured as a light exiting side; the second electrode layer and the third electrode layer are transparent electrode layers; and the work function of the second electrode layer is greater than the LUMO energy level of the electron transport layer and smaller than the work function of the third electrode layer.