Abstract: An image processing method and apparatus based on machine learning are disclosed. The image processing method based on machine learning, according to the present invention, may comprise the steps of: generating a first corrected image by inputting an input image to a first convolution neural network; generating an intermediate image on the basis of the input image; performing machine learning on a first loss function of the first convolution neural network on the basis of the first corrected image and the intermediate image; and performing machine learning on a second loss function of the first convolution neural network on the basis of the first corrected image and a natural image.

Abstract: The present invention provides a pharmaceutical composition including a combination of at least two cannabinoids, and methods of using same, such as for treating a NOTCH 1-related disease.

Abstract: Provided is a system and method for estimating an end-to-end delay between blockchain nodes in peer-to-peer (P2P) networks. The system includes a coordinate system construction unit configured to designate an origin node and anchor nodes among participating nodes having a distributed ledger of P2P networks, construct a first coordinate system of a predetermined dimension by exchanging control messages between the origin node and the anchor nodes and the participating nodes, and construct a second coordinate system of another predetermined dimension and a dimension determination unit configured to determine a dimension to be applied to the current P2P networks by comparing dimension-specific delays or control message overheads of the first coordinate system and the second coordinate system.

Abstract: Provided is a novel mixed peptide antigen for production of a formylmethionine antibody. According to the present disclosure, the formylmethionine-specific antibody produced using the antigen peptide can detect formylmethionine by universally binding to peptides or proteins containing formylmethionine, and has higher sensitivity than antibodies using conventional single antigen peptides.

Abstract: A semiconductor device includes a substrate, source/drain regions on the substrate, a channel layer between the source/drain regions and including indium gallium zinc oxide (IGZO), a variable resistance layer on the channel layer and including metal oxide that satisfies a stoichiometric ratio of metal to oxygen, a gate insulating layer on the variable resistance layer and including metal oxide that does not satisfy the stoichiometric ratio of metal to oxygen, and a gate electrode on the gate insulating layer.

Abstract: A method of treating a disease or disorder for which an increase in immune cells in the brain is therapeutic in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which specifically binds and increases activity of a receptor selected from the group consisting of a 5HT2C receptor, a 5HT2A receptor and a 5HT2B receptor in the postcentral gyrus and/or the choroid plexus (CP) of the brain of the subject. Compositions for treating these diseases are also disclosed.

Abstract: A thin film transistor includes a gate electrode, an insulating layer disposed on the gate electrode, and an active layer disposed on the insulating layer, where the active layer includes a perovskite compound represented by the following Formula: AB(1-u)C(u)[X(1-v)Y(v)]3, where A is a monovalent organic cation, a monovalent inorganic cation, or any combination thereof, B is Sn2+, C is a divalent cation or trivalent cation, X is a monovalent anion, Y is a monovalent anion different from X, u is a real number greater than 0 and less than 1, and v is a real number greater than 0 and less than 1.

Abstract: The present invention relates to a method for producing an artificial scalp model using a 3D printing-based multi-point multi-nozzles, and an artificial scalp model manufactured by using same, in which a dermal mimetic body can be created by using a plurality of nozzle arrays, a pore mimic structure can be generated, and hair follicle spheroids can then be created by 3D printing. In the method for producing an artificial scalp model using a 3D printing-based multi-point multi-nozzles and the artificial scalp model manufactured by using same, according to the present invention, by mimicking the hair of a healthy scalp, a plurality of arrayed hair follicle cells can be generated by 3D printing, and by using this, the effect of maximizing the treatment effect of scarring alopecia is obtained.

Abstract: The present invention relates to a method for producing an adipose model through environmental control and an adipose model created using same, the method comprising the steps of: providing a first bioink, which is cell-unfriendly; creating a bath suspension with a predetermined volume by using the first bioink; providing a second bioink comprising preadipocytes; 3Dprinting the second bioink in the bath suspension so as to produce an adipose model; and culturing the bath suspension in which the adipose model is disposed. The method for producing an adipose model through environmental control and the adipose model created using same, according to the present disclosure, form environments for a 3D-printed adipose model, and limit the proliferation area of adipose cells and induce the differentiation thereof, and thus can maximize similarity with actual adipose tissues.

Abstract: Exemplary embodiments of the present disclosure include systems and methods for treatment of occlusions, including coronary artery chronic total occlusions.

Abstract: Compositions comprising a) one or more amorphous superconductor layers bound to one or more flexible substrate layers, or b) one or more superconductor layers bound to one or more layers of a high dielectric material are disclosed. Furthermore, provided herein are articles comprising one or more compositions of the invention and method of manufacturing thereof.

Abstract: Disclosed are an open-top two-photon light sheet microscope and an operating method thereof. The open-top two-photon light sheet microscope is capable of obtaining high-depth imaging, high-contrast resolution, and double contrast based on a Bessel beam, and enables rapid three-dimensional imaging by continuously capturing tissue on a per-plane basis without an optical clearing process or a sectioning process, and an operating method thereof.

Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.

Abstract: Provided is a system and method for estimating an end-to-end delay between blockchain nodes in peer-to-peer (P2P) networks. The system includes a coordinate system construction unit configured to designate an origin node and anchor nodes among participating nodes having a distributed ledger of P2P networks, construct a first coordinate system of a predetermined dimension by exchanging control messages between the origin node and the anchor nodes and the participating nodes, and construct a second coordinate system of another predetermined dimension and a dimension determination unit configured to determine a dimension to be applied to the current P2P networks by comparing dimension-specific delays or control message overheads of the first coordinate system and the second coordinate system.

Abstract: Provided are a two-terminal stretchable touch array sensor and a method of preparing the two-terminal stretchable touch array sensor, and the two-terminal stretchable touch array sensor includes an upper electrode including an upper electrode pattern embedded in a first elastic substrate, a lower electrode including a lower electrode pattern embedded in a second elastic substrate, a spacer interposed between the upper electrode and the lower electrode, and a first terminal and a second terminal each included at the same position of an end of the upper electrode pattern and an end of the lower electrode pattern.

Abstract: Disclosed are embodiments of shortest path search in an obstacle environment. Provided is a shortest path search method including: creating an epsilon graph; and determining k closest points from a query point on the basis of the graph, wherein the creating of the graph includes: creating a node group of nodes on the basis of a point group of arrival points; creating an edge group of edges on the basis of the created nodes; setting, on the basis of an obstacle group of at least one obstacle, whether each of the nodes is a valid node or a non-valid node; setting, on the basis of the obstacle group, whether each of the edges is a valid or non-valid edge; and including, for each of the arrival points, a particular arrival point on an anchor list of a valid node closest from the particular arrival point among the valid nodes.

Abstract: An object detection device is provided. The object detection device may include an input device for receiving an input image, an object detection model for generating a plurality of input images of different resolutions using the input image, a processor for acquiring a plurality of pyramid images of different resolutions using the plurality of input images, an important object image representing a preset important object in the input image based on the plurality of pyramid images, and an output device for outputting the important object image. A method is also disclosed.

Abstract: Disclosed is a multi-constraint qubit allocation method and a quantum apparatus using the same. The method comprises generating an interaction graph representing a quantum circuit on the basis of the number of two-qubit gates, determining edge weights between connected nodes in the interaction graph by introducing a fitting coefficient for a decay effect, searching for an isomorphic part, layout graph, between target hardware and the interaction graph by graph matching, and performing frequency matching for a layout graph by searching for frequency allocated to each location of qubits by limiting unidirectional movement on each of an x-axis and a y-axis of a hardware plane of the target hardware to a range from ?1 to +1.

Abstract: A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.

Abstract: Systems comprising a first polynucleotide comprising a regulatory element operatively linked to an open reading frame encoding an invertase enzyme and a second polynucleotide comprising a repressible regulatory element operatively linked to an open reading frame encoding a glucose oxidase enzyme wherein the repressible element inhibits transcription in response to hydrogen peroxide are provided. Cells and compositions comprising a system of the invention, as well as methods using the system of the invention, are also provided, as is artificial honey.