Patents Assigned to Devgen NV
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Publication number: 20220170018Abstract: Disclosed are double stranded RNA molecules that are toxic to flea beetles, particularly the flea beetle species Psylliodes chrysocephala, Phyllotreta nemorum, Phyllotreta striolata, Phyllotreta armoraciae, Phyllotreta atra and Phyllotreta cruciferae. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.Type: ApplicationFiled: March 13, 2021Publication date: June 2, 2022Applicant: DEVGEN NVInventors: Lien DE SCHRIJVER, Kaat CAPPELLE, Lies DEGRAVE, Myriam BEGHYN, Yann NAUDET
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Patent number: 11286476Abstract: Methods of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the cell composition a compound having the function of a protein—or amine—cross linking agent and/or an acid, and compositions comprising the cells comprising dsRNA, and protein cross linking agents and/or acids, as well as the use of the cross linking agents and/or acids in the method.Type: GrantFiled: September 28, 2017Date of Patent: March 29, 2022Assignees: SYNGENTA PARTICIPATIONS AG, Devgen NVInventors: Pascale Feldmann, Jeffrey David Fowler, Nema Devi Jhurry, Isabelle Maillet, Marta Omedes Pujol
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Publication number: 20220049256Abstract: Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.Type: ApplicationFiled: November 5, 2021Publication date: February 17, 2022Applicant: DEVGEN NVInventors: Yann NAUDET, Myriam BEGHYN, Lien DE SCHRIJVER, Isabelle MAILLET, Annelies PHILIPS
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Patent number: 11198868Abstract: Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.Type: GrantFiled: November 6, 2018Date of Patent: December 14, 2021Assignee: DEVGEN NVInventors: Yann Naudet, Myriam Beghyn, Lien De Schrijver, Isabelle Maillet, Annelies Philips
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Publication number: 20210254093Abstract: The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.Type: ApplicationFiled: March 8, 2021Publication date: August 19, 2021Applicant: DEVGEN NVInventors: Thierry BOGAERT, Romaan RAEMAEKERS, Yann NAUDET
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Publication number: 20210123069Abstract: Disclosed are double stranded RNA molecules that are toxic to flea beetles, particularly the flea beetle species Psylliodes chrysocephala, Phyllotreta nemorum, Phyllotreta striolata, Phyllotreta armoraciae, and Phyllotreta cruciferae. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.Type: ApplicationFiled: April 17, 2019Publication date: April 29, 2021Applicant: DEVGEN NVInventors: Lien DE SCHRIJVER, Kaat CAPPELLE, Lies DEGRAVE, Yann NAUDET, Steffy DENORME
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Patent number: 10941415Abstract: The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.Type: GrantFiled: January 12, 2018Date of Patent: March 9, 2021Assignee: DEVGEN NVInventors: Thierry Bogaert, Romaan Raemaekers, Yann Naudet
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Publication number: 20200407719Abstract: Disclosed are double stranded RNA molecules that are toxic to pollen beetles, particularly the pollen beetle Meligethes aeneus. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.Type: ApplicationFiled: February 13, 2019Publication date: December 31, 2020Applicant: Devgen NVInventors: Yann NAUDET, Lien DESCHRIJVER, Kaat CAPPELLE, Steffy Donorme
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Publication number: 20200239891Abstract: Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.Type: ApplicationFiled: November 6, 2018Publication date: July 30, 2020Applicant: DEVGEN NVInventors: Yann Naudet, Myriam Beghyn, Lien De Schrijver, Isabelle Maillet, Annelies Philips
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Publication number: 20200181611Abstract: The present invention provides an RNA comprising in the 5? to 3? direction a first sequence and a second sequence, the first sequence being spaced apart from the second sequence by a spacer sequence, the first and second sequences being substantially complementary and forming a duplex via Watson and Crick base pairing, the second sequence being able to hybridise with the mRNA of a target gene in an organism, the RNA being substantially in the form of a hairpin, the second sequence being fully complementary to the said mRNA along the region at which it hybridises, the first sequence comprising nucleotide bases which do not Watson and Crick base pair with the corresponding bases in the second sequence of the duplex wherein the duplex does not comprise regions of 3 or more consecutive mismatched bases or an RNA comprising in the 5? to 3? direction a first sequence and a second sequence, the first sequence being spaced apart from the second sequence by a spacer sequence, the first and second sequences being substType: ApplicationFiled: October 19, 2016Publication date: June 11, 2020Applicant: Devgen NVInventors: Wendy MADDELEIN, Isabelle MAILLET
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Publication number: 20200140884Abstract: The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.Type: ApplicationFiled: January 21, 2020Publication date: May 7, 2020Applicant: DEVGEN NVInventors: Thierry Bogaert, Romaan Raemaekers, Yann Naudet
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Publication number: 20200045977Abstract: The present invention provides a method of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the cell composition a compound having the function of a protein—or amine—cross linking agent and/or an acid. The invention also comprises compositions comprising the cells comprising dsRNA, and protein cross linking agents and/or acids, as well as the use of said cross linking agents and/or acids in the method.Type: ApplicationFiled: September 28, 2017Publication date: February 13, 2020Applicants: SYNGENTA PARTICIPATIONS AG, Devgen NVInventors: Pascale FELDMANN, Jeffrey David FOWLER, Nema Devi JHURRY, Isabelle MAILLET, Marta OMEDES PUJOL
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Publication number: 20190256851Abstract: The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.Type: ApplicationFiled: May 7, 2019Publication date: August 22, 2019Applicant: DEVGEN NVInventors: Myriam Beghyn, Thierry Andre Olivier Eddy Bogaert, Pascale Feldmann, Romaan Raemaekers
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Publication number: 20190127756Abstract: The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.Type: ApplicationFiled: January 17, 2018Publication date: May 2, 2019Applicant: DEVGEN NVInventors: Marc Van De Craen, Geert Karel Maria Plaetinck, Isabel Vercauteren, Marc Georges Logghe, Thierry Andre Olivier Eddy Bogaert, Richard Zwaal
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Publication number: 20180289015Abstract: The present invention provides a method of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell lysate, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the lysate a compound having the function of a protein- or amine-cross linking agent. The invention also comprises compositions comprising the lysate comprising dsRNA, and protein cross linking agents, as well as the use of said agents in the method.Type: ApplicationFiled: September 27, 2016Publication date: October 11, 2018Applicants: SYNGENTA CROP PROTECTION LLC, DEVGEN NVInventors: Pascale Feldmann, Jeffrey David Fowler, Wendy Maddelein, Nina Cromheecke, Isabelle Maillet
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Publication number: 20180148737Abstract: The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.Type: ApplicationFiled: January 12, 2018Publication date: May 31, 2018Applicant: DEVGEN NVInventors: Thierry Bogaert, Romaan Raemaekers, Yann Naudet
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Patent number: 9982258Abstract: The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules.Type: GrantFiled: September 12, 2014Date of Patent: May 29, 2018Assignee: Devgen NVInventors: Romaan Raemaekers, Pascale Feldmann, Geert Plaetinck, Irene Nooren, Frederic Pecqueur, Laurent Kubler, Nicole Damme, Lies Degrave, Isabel Remory, Thierry Bogaert
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Publication number: 20180142237Abstract: The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules.Type: ApplicationFiled: September 12, 2014Publication date: May 24, 2018Applicant: DEVGEN NVInventors: Romaan RAEMAEKERS, Pascale FELDMANN, Geert PLAETINCK, Irene NOOREN, Els VAN BLEU, Frederic PECQUEUR, Laurent KUBLER, Nicole DAMME, Lies DEGRAVE, Isabel REMORY, Thierry BOGAERT
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Patent number: 9957523Abstract: The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for making transgenic plants that express the double stranded RNA molecules, as well as pesticidal agents and commodity products produced by the inventive plants.Type: GrantFiled: July 7, 2014Date of Patent: May 1, 2018Assignee: Devgen NVInventors: Romaan Raemaekers, Pascale Feldmann, Irene Nooren, Geert Plaetinck, Frederic Pecqueur, Els Van Bleu, Thierry Bogaert
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Patent number: 9944948Abstract: The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of expression of target genes in insect pests using interfering ribonucleic acid (RNA) molecules. Also described are transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species. Compositions containing the interfering RNAs of the invention are also provided.Type: GrantFiled: October 27, 2011Date of Patent: April 17, 2018Assignee: Devgen NVInventors: Thierry Bogaert, Romaan Raemaekers, Yann Naudet