Abstract: The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
Type:
Application
Filed:
September 17, 2014
Publication date:
May 14, 2015
Applicant:
DEVGEN PTE LTD.
Inventors:
Marc Van De Craen, Phuay-Yee Goh, Marc Georges Logghe, Yee-Ling Khu, Katherine An Hilde Mortier, Thierry Andre Oliver Eddy Bogaert
Abstract: The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.
Type:
Application
Filed:
May 12, 2010
Publication date:
December 9, 2010
Applicant:
Devgen Pte Ltd.
Inventors:
Marc Van De Craen, Phuay-Yee Goh, Marc Georges Logghe, Yee-Ling Khu, Katherine Mortier, Thierry Andre Olivier Eddy Bogaert