Patents Assigned to DeWitt Ross & Stevens S.C.
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING PLURIPOTENT STEM CELLS INTO PRIMITIVE BLOOD CELLS AND USES THEREOF
    Publication number: 20130171110
    Abstract: Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, BMP4, VEGF, prostaglandin E2 pathway stimulants, TPO, SCF, FLT-3, EPO, TGF?1, p38 MAPK inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, RXR agonists, Cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided.
    Type: Application
    Filed: December 5, 2012
    Publication date: July 4, 2013
    Applicant: DeWitt Ross & Stevens S.C.
    Inventor: DeWitt Ross & Stevens S.C.