Patents Assigned to DEWPOINT THERAPEUTICS, INC.
  • Methods of characterizing condensate-associated characteristics of compounds and uses thereof
    Patent number: 11493519
    Abstract: Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: November 8, 2022
    Assignee: DEWPOINT THERAPEUTICS, INC.
    Inventors: Bruce Aaron Beutel, Peter Jeffrey Dandliker, Stephen Paul Hale, Mark Andrew Murcko, Edgar Erik Boczek, Matthäus Mittasch, Diana Maria Mitrea
  • Methods of screening for condensate-associated specificity and uses thereof
    Patent number: 11340231
    Abstract: Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: May 24, 2022
    Assignee: DEWPOINT THERAPEUTICS, INC.
    Inventors: Alexander Szewczak, Ina Poser, Mark Andrew Murcko, Stephen Paul Hale, Bruce Aaron Beutel