Patents Assigned to DEZIMA PHARMA B.V.
  • CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) INHIBITOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID INHIBITOR FOR USE IN THE TREATMENT OR PREVENTION OF CARDIOVASCULAR DISEASES
    Publication number: 20210228580
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Cholesteryl ester transfer protein (CETP) inhibitor and pharmaceutical compositions comprising said inhibitor for use in the treatment or prevention of cardiovascular diseases
    Patent number: 11013742
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: May 25, 2021
    Assignee: DEZIMA PHARMA B.V.
    Inventors: John Ford, Patrick Round, John Kastelein, Atsuhiro Kawaguchi, Koichi Tomiyasu, Kozo Oka
  • Cholesteryl Ester Transfer Protein (CETP) Inhibitor and Pharmaceutical Compositions Comprising Said Inhibitor for Use in the Treatment or Prevention of Cardiovascular Diseases
    Publication number: 20200230138
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said CETP inhibitor.
    Type: Application
    Filed: April 9, 2020
    Publication date: July 23, 2020
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors
    Patent number: 10300059
    Abstract: The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (CETP) inhibitor and a HMG CoA Reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: May 28, 2019
    Assignee: DEZIMA PHARMA B.V.
    Inventors: John Ford, Patrick Round, John Kastelein
  • Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
    Patent number: 10112904
    Abstract: The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (CETP), show effects of increasing HDL cholesterol level and decreasing LDL cholesterol level, and can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, hyperlipidemia, dyslipidemia and the like.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: October 30, 2018
    Assignee: DEZIMA PHARMA B.V.
    Inventors: John Ford, Johannes Paulus Gerardus Seerden, Amandine Ledru
  • PHARMACEUTICAL COMPOSITION AND THERAPEUTIC COMBINATION COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND HMG CoA REDUCTASE INHIBITORS
    Publication number: 20180000818
    Abstract: The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (CETP) inhibitor and a HMG CoA Reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
    Type: Application
    Filed: August 3, 2015
    Publication date: January 4, 2018
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN
  • Process for Preparing Synthetic Intermediates for Preparing Tetrahydroquinoline Derivatives
    Publication number: 20170267640
    Abstract: The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (CETP), show effects of increasing HDL cholesterol level and decreasing LDL cholesterol level, and can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, hyperlipidemia, dyslipidemia and the like.
    Type: Application
    Filed: July 29, 2015
    Publication date: September 21, 2017
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Johannes Paulus Gerardus SEERDEN, Amandine LEDRU