Abstract: A method of securing an access port to a vessel can include positioning an access port adjacent to a wall of the vessel. The access port can include an implantation passageway and a guidance passageway that is connected to the implantation passageway. The implantation passageway can be open, during the positioning of the access port, at a position proximal to a location at which the implantation passageway and the guidance passageway are connected. The method can further include forming an opening in the wall of the vessel via instruments that extend through the implantation passageway. The method can include securing the access port to the vessel such that the implantation passageway is in fluid communication with an interior of the vessel via the opening in the wall of the vessel. The method can also include sealing the implantation passageway at the position proximal to the guidance passageway.