Patents Assigned to DFB BIOTECH, INCORPORATED
  • Publication number: 20080108115
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Application
    Filed: August 9, 2007
    Publication date: May 8, 2008
    Applicant: DFB BIOTECH, INCORPORATED
    Inventors: Venkataraman Bringi, Prakash Kadkade, Christopher Prince, Braden Roach