Abstract: A method for dynamic pixel mass spectrometric imaging, or dynamic pixel imaging is disclosed. The method includes striking a sample to be scanned with a laser beam so that the laser beam releases analytes from the sample. The laser beam and the sample are then displaced relative to one another so that the laser beam substantially continuously traces a predefined path on the sample to release analytes from the sample along the predefined path. A mass analysis of the released analytes is performed.
Type:
Grant
Filed:
July 19, 2007
Date of Patent:
May 8, 2012
Assignee:
DH Technologies Pte. Ltd.
Inventors:
Andrew James, George Scott, Min J. Yang
Abstract: A method of photo-fragmentation is provided generating a beam of ions from a sample with an ion source, filtering the beam of ions in a filtering region to select desired ions, and photo-fragmenting the desired ions in a photo-fragmentation region having a higher pressure than the filtering region to generate fragment ions predominantly by prompt fragmentation. An apparatus for photo-fragmentation is provided having an ion source configured to generate a beam of ions from a sample, a filtering region for selecting desired ions, a photo-fragmentation region having a higher pressure than the filtering region to generate predominantly prompt fragmentation of the selected desired ions, an inlet for providing gas to the photo-fragmentation region to maintain a pressure in the photo-fragmentation region that is higher than the pressure in the filtering region, and a photon source emitting a beam of light for photo-fragmenting the selected ions in the photo-fragmentation region.
Abstract: A novel curved collision cell for a mass spectrometer is described. The collision cell includes a straight section having a length that is selected to cause a precursor ion entering the straight section to lose a desired amount of kinetic energy such that when the precursor ion enters the curved section of the collision cell the precursor ion will tend to neither escape nor contact the collision cell, and thereby tending to survive its passage within the curved portion.
Abstract: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
Type:
Grant
Filed:
January 7, 2008
Date of Patent:
March 22, 2011
Assignee:
DH Technologies Pte. Ltd.
Inventors:
Darryl J. C. Pappin, Michael Bartlet-Jones