Abstract: A proportioning system for compounding a bicarbonate-containing dialysate suitable for hemodialysis of human blood is disclosed. An aqueous alkali metal carbonate solution and an aqueous hydrochloric acid-containing solution are combined at a predetermined volumetric rate, and the conductivity as well as the hydrogen ion activity of the resulting bicarbonate-containing dialysate is monitored.

Abstract: An aqueous acid concentrate in unit dosage form, suitable for use in compounding a hemodialysis dialysate, is disclosed. The concentrate contains water, chloride ion in a concentration of about 3.5 Molar to about 4.7 Molar, sodium ion in a concentration of about 1.9 Molar to about 2.7 Molar, and dextrose in a concentration of about 0 Molar to about 0.4 Molar. Additionally, the concentrate may contain acetate group in a concentration of up to about 0.525 Molar, calcium ion in a concentration of up to about 0.125 Molar, potassium ion in a concentration of up to about 0.14 Molar, and magnesium ion in a concentration of up to about 0.09 Molar.

Abstract: A dialysate solution containing sodium bicarbonate is provided in which the sodium bicarbonate is generated just prior to dialysis by combining an aqueous sodium carbonate-containing stream with an aqueous stream containing hydrochloric acid, acetic acid or a mixture of these acids in at least two stages with an excess of acid in the first stage.