Patents Assigned to DIAGNOSTIC BIOCHIPS, INC.
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Patent number: 10285605Abstract: In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.Type: GrantFiled: September 27, 2017Date of Patent: May 14, 2019Assignee: DIAGNOSTIC BIOCHIPS, INC.Inventors: Brian Jamieson, Jennette Mateo
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Patent number: 10188304Abstract: In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.Type: GrantFiled: July 24, 2012Date of Patent: January 29, 2019Assignee: Diagnostic Biochips, Inc.Inventors: Brian Jamieson, Jennette Mateo
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Patent number: 9883826Abstract: Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.Type: GrantFiled: July 15, 2013Date of Patent: February 6, 2018Assignee: DIAGNOSTIC BIOCHIPS, INC.Inventors: Brian Jamieson, Mary Emma Gorham Bigelow
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Publication number: 20180028119Abstract: In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.Type: ApplicationFiled: September 27, 2017Publication date: February 1, 2018Applicant: DIAGNOSTIC BIOCHIPS, INC.Inventors: Brian Jamieson, Jennette Mateo
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Patent number: 9801559Abstract: In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.Type: GrantFiled: July 25, 2011Date of Patent: October 31, 2017Assignee: DIAGNOSTIC BIOCHIPS, INC.Inventors: Brian Jamieson, Jennette Mateo
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Publication number: 20170261499Abstract: Provided herein are aptamer arrays useful to detect target molecules that are largely similar to each other in structure (such as monoamine neurotransmitters), and methods of detecting such molecules, employing aptamers with differing sensitivities to each target molecule.Type: ApplicationFiled: November 25, 2015Publication date: September 14, 2017Applicant: DIAGNOSTIC BIOCHIPS, INC.Inventor: Emma Bigelow
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Publication number: 20170258404Abstract: Provided herein is a coated biosensor and a method of preserving a coated biosensor to protect it during implantation into the brain or other tissues by coating the biosensor with a protective coating.Type: ApplicationFiled: November 25, 2015Publication date: September 14, 2017Applicant: DIAGNOSTIC BIOCHIPS, INC.Inventors: Emma Bigelow, Brian Jamieson
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Publication number: 20170020422Abstract: The specification and drawings show an embodiment of the present invention in the form of a device comprising one or more biosensors either placed or imbedded in a catheter, needle or combination of the two. The catheter or needle comprises exclusionary slits upstream of the biosensor(s), angled so that fluid flows in through the slits and down past the biosensors. The wires connecting the biosensors to external monitoring and/or analytical apparatus are wired through the catheter or needle material. Also provided herein are methods for detection of small molecules using the device described herein.Type: ApplicationFiled: April 8, 2015Publication date: January 26, 2017Applicant: DIAGNOSTIC BIOCHIPS, INC.Inventors: Emma Bigelow, Rohan Pais, Rob Collins, Brian Jamieson