Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.
Type:
Grant
Filed:
May 27, 2022
Date of Patent:
July 22, 2025
Assignees:
The Research Foundation for The State University of New York, KDx Diagnostics, Inc.
Inventors:
Kenneth R. Shroyer, Luisa F. Escobar-Hoyos, Nam Kim
Abstract: A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed.
Type:
Grant
Filed:
January 22, 2021
Date of Patent:
July 22, 2025
Assignee:
Siemens Healthcare Diagnostics Inc.
Inventors:
Jay J. Li, David J. Ledden, Eric Scott Cowden, Donglai Lu
Abstract: To train a machine learning routine (BNN), a sequence of first training data (PIC) is read in through the machine learning routine. The machine learning routine is trained using the first training data, wherein a plurality of learning parameters (LP) of the machine learning routine is set by the training. Furthermore, a value distribution (VLP) of the learning parameters, which occurs during the training, is determined and a continuation signal (CN) is generated on the basis of the determined value distribution of the learning parameters. Depending on the continuation signal, the training is then continued with a further sequence of the first training data or other training data (PIC2) are requested for the training.
Type:
Grant
Filed:
July 29, 2019
Date of Patent:
July 15, 2025
Assignee:
Siemens Healthcare Diagnostics Inc.
Inventors:
Markus Michael Geipel, Stefan Depeweg, Christoph Tietz, Gaby Marquardt, Daniela Seidel
Abstract: A method of analyzing a specimen includes detecting a specimen integrity error in the specimen; capturing an image of the specimen; sending the image of the specimen to a customer support center at a remote location; analyzing the image of the specimen at the customer support center; and determining a cause of the specimen integrity error in response to analyzing the image of the specimen. Diagnostic analyzers and diagnostic systems are also disclosed.
Abstract: Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.
Abstract: An X-ray diffractometer system analyzes objects including biological tissue samples and physical and chemical samples. The diffractometer system includes an X-ray beam projector that projects an incident micro-beam of X-ray at an analysis target, an X-ray receiver including an X-ray detector array to detect the transmitted X-rays passed through the object and X-rays that the target diffracts, and a computer workstation for system control and data analysis. The X-ray beam projector may include a radiation source, a beam forming system including at least one of a monochromator, a collimator, and focusing device. The computer workstation may control the X-ray devices and positioning mechanisms and motors, may acquire, process, store, or display data received from diffractometric examination, and may also calculate parameters of the three-dimensional reciprocal lattice of the analyzed target.
Type:
Grant
Filed:
April 20, 2023
Date of Patent:
June 17, 2025
Assignee:
Arion Diagnostics, Inc.
Inventors:
Alexander P. Lazarev, Pavel I. Lazarev, Delvin Tai Wai Yuk
Abstract: Cancer immunology provides promising new avenues for cancer treatment but validation of potential neoantigens to target is costly and expensive. Analysis of MHC binding affinity, antigen processing, similarity to known antigens, predicted expression levels (as mRNA or proteins), self-similarity, and mutant allele frequency, provides screening method to identify and prioritize candidate neoantigens using sequencing data. Methods of the invention thereby save time and money by identifying the priority candidate neoantigens for further experimental validation.
Type:
Grant
Filed:
December 31, 2019
Date of Patent:
June 17, 2025
Assignee:
Personal Genome Diagnostics Inc.
Inventors:
Victor Velculescu, Theresa Zhang, James Robert White, Luis Diaz
Abstract: Methods of detecting and flagging and/or suppressing aberrant results caused by incomplete dispersion of an immunoassay reagent used in a turbidimetric immunoassay are disclosed.
Abstract: Systems and methods are disclosed herein for determining a diagnosis based on a base skin tone of a patient. In an embodiment, the system receives a base skin tone image of a patient, generates a calibrated base skin tone image by calibrating the base skin tone image using a reference calibration profile, and determines a base skin tone of the patient based on the calibrated base skin tone image. The system receives a concern image of a portion of the patient's skin, and selects a set of machine learning diagnostic models from a plurality of sets of candidate machine learning diagnostic models based on the base skin tone of the patient, each of the sets of candidate machine learning diagnostic models trained to receive the concern image and output a diagnosis of a condition of the patient.
Type:
Grant
Filed:
May 13, 2024
Date of Patent:
June 3, 2025
Assignee:
Digital Diagnostics Inc
Inventors:
Elliot Swart, Elektra Efstratiou Alivisatos, Joseph Ferrante, Elizabeth Asai
Abstract: Systems and methods are provided herein for minimizing retinal exposure to flash during image gathering for diagnosis. In an embodiment, a system captures a plurality of retinal images of different retinal regions. The system determines that a first portion of a first image does not meet a criterion while a second portion of the first image does meet the criterion, identifies a portion of the retina depicted in the first portion that does not meet the criterion, and determines whether the portion of the retina is depicted in a third portion of a second image and whether the third portion meets the criterion. Responsive to determining that the third portion meets the criterion, the system performs the diagnosis. Responsive to determining that the portion of the retina is not depicted in the second image, the system captures an additional image of the retinal region.
Type:
Grant
Filed:
November 29, 2023
Date of Patent:
June 3, 2025
Assignee:
Digital Diagnostics Inc.
Inventors:
Warren James Clarida, Ryan Earl Rohret Amelon, Abhay Shah, Jacob Patrick Suther, Meindert Niemeijer, Michael David Abramoff
Abstract: Microfluidic devices, method for making and using same are disclosed. The microfluidic device can be made by applying a reagent in liquid form into a sample treatment site within a substrate base. The substrate base has hydrophilic properties bordering a flow channel, and has an application site, the sample treatment site and an analytical site. The flow channel is sized and configured so as to draw a sample applied into the application site to the analytical site through the sample treatment site by capillary action. The reagent is freeze-dried within the sample treatment site.
Type:
Grant
Filed:
March 12, 2020
Date of Patent:
May 27, 2025
Assignee:
Siemens Healthcare Diagnostics Inc.
Inventors:
Aaron Kauffmann, Jeffrey Mayfield, David Ledden
Abstract: A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the isolated particles. The centrifugation procedures are performed at a speed not exceeding about 200,000 g. The extracted nucleic acids contain both 18S and 28S rRNA.
Type:
Grant
Filed:
March 24, 2021
Date of Patent:
May 27, 2025
Assignee:
Exosome Diagnostics, Inc.
Inventors:
Johan Karl Olov Skog, Leileata M. Russo
Abstract: Analyzers and methods of use are disclosed, including a blood analyzer comprising a light source to transmit an optical signal; a detector to generate data indicative of optical signal intensity; a transparent sample vessel between the light source and the detector; a dispensing device to pass a first portion of the blood sample comprising whole blood or lysed blood into the vessel at a first instance of time, and to pass a plasma portion of the blood sample into the vessel at a second instance of time; a controller to cause a processor to obtain first and second data generated by the detector, the first data indicative of the optical signal passing through the first portion of the blood sample and the second data indicative of the optical signal passing through the plasma, to determine a total absorbance spectrum in which the first data is adjusted by the second data.
Abstract: A method of characterizing a specimen and specimen container to be analyzed in an automated diagnostic analysis system. The method can provide a segmentation determination and/or an HILN determination (hemolysis, icterus, lipemia, or normal) of the specimen while protecting patient information. The method includes capturing an image of a specimen container via an image capture device, identifying a label affixed to the specimen container in the captured image via an anonymization network, and editing the captured image via the anonymization network to mask some or all information present in the label so that it is removed from the captured image. Quality check modules and systems configured to carry out the method are also described, as are other aspects.
Type:
Grant
Filed:
October 22, 2020
Date of Patent:
May 13, 2025
Assignee:
Siemens Healthcare Diagnostics Inc.
Inventors:
Venkatesh NarasimhaMurthy, Vivek Singh, Yao-Jen Chang, Benjamin S. Pollack, Ankur Kapoor, Rayal Raj Prasad Nalam Venkat
Abstract: A method for performing a lateral flow assay is provided. The method includes inserting a sample cartridge (201) in a dark chamber (220) and activating a light emitter (251) in the dark chamber (220). The method includes focusing an optical coupling mechanism (115a, 115b) in an image-capturing device (100a, 100b) to optimize an image of a sensitive area (202) in the sample cartridge (201) and capturing, with an image capturing device (100a, 100b), an image of a sensitive area (202) in the sample cartridge (201) after a selected period of time. The method also includes providing the image of the sensitive area (202) to a processor, wherein the processor comprises an image-capturing application (122). A system and a computer-implemented method to perform at least partially the above method are also provided.
Type:
Grant
Filed:
January 15, 2020
Date of Patent:
May 13, 2025
Assignee:
Ortho-Clinical Diagnostics, Inc.
Inventors:
Andrew Attila Pal, Werner Kroll, Adonis Stassinopoulos
Abstract: The techniques described herein relate to systems and methods for diagnosing diseases in animal patients. In some cases, a method includes providing a set of global data to a global data center and processing the set of global data and categorizing it into data clusters, where each data cluster corresponds to a diagnostic indicator for assessment of a physiological or pathological condition. The method can further include measuring data of a local patient using measurement equipment of a local autonomous cell and communicating the local measurement data from the local autonomous cell to the global data center. The local measurement data can be processed, and the processed local measurement data can be compared with the data clusters to determine a local diagnostic indicator for the local patient. The local diagnostic indicator can then be communicated from the global data center to the local autonomous cell.
Type:
Application
Filed:
November 2, 2023
Publication date:
May 8, 2025
Applicant:
Arion Diagnostics, Inc.
Inventors:
Alexander P. LAZAREV, Delvin Tai Wai YUK, Pavel LAZAREV
Abstract: Biotin-trap compositions are disclosed that contain particles having an inner polymer coating layer disposed on at least a portion of an outer surface thereof and a biotin-specific binding partner conjugated to the inner polymer coating layer. The biotin-trap compositions may further include an outer polymer coating layer disposed about the biotin-specific binding partner. The biotin-trap compositions specifically bind to free biotin but do not substantially bind to biotin conjugated to other moieties, such as biotinylated assay reagents. Also disclosed are kits and microfluidics devices that include the biotin-trap compositions, as well as methods of producing and using the biotin-trap compositions.
Type:
Application
Filed:
December 16, 2022
Publication date:
May 8, 2025
Applicant:
Siemens Healthcare Diagnostics Inc.
Inventors:
Zhu Teng, Jesse Spillane, Jie Li, Thomas Kennedy, Karen Krakowski, Izak Bahar, Tie Wei