Abstract: Method of monitoring or diagnosing disease conditions, including disease of the prostrate, that involve measuring a combination of tumour markers and at least one component of the IGF axis. The invention is exemplified with prostate cancer and benign prostatic hyperplasia, the tumor marker prostate specific antigen, and the insulin-like growth factors and their binding proteins.
Type:
Application
Filed:
March 7, 2002
Publication date:
January 23, 2003
Applicant:
Diagnostic System Laboratories, Inc.
Inventors:
M. Javad Khosravi, Anastasia Diamandi, Jehangir Mistry
Abstract: Method of monitoring or diagnosing disease conditions, including disease of the prostate, that involve measuring a combination of tumor markers and at least one component of the IGF axis. The invention is exemplified with prostate cancer and benign prostatic hyperplasia, the tumor marker prostate specific antigen, and the insulin-like growth factors and their binding proteins.
Type:
Grant
Filed:
January 18, 2000
Date of Patent:
September 10, 2002
Assignee:
Diagnostic Systems Laboratories, Inc.
Inventors:
M. Javad Khosravi, Anastasia Diamandi, Jehangir Mistry
Abstract: The present invention relates to screening or testing for insulin like growth factors, insulin like growth factor binding proteins and/or acid labile subunit by the use of a solid support. Blood is collected onto a solid support, such as paper, and subsequently the analytes of interest are extracted for testing.
Type:
Grant
Filed:
September 24, 1999
Date of Patent:
February 19, 2002
Assignee:
Diagnostic Systems Laboratories, Inc.
Inventors:
M. Javad Khosravi, Jehangir Mistry, Anastasia Diamandi
Abstract: A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be assayed. The method involves capturing the IGFBP complex with a first antibody coupled to a solid phase and detecting the complex with a second antibody coupled to a label. A set of monoclonal and polyclonal antibodies usefutl for the assay is also provided.
Type:
Grant
Filed:
March 9, 1998
Date of Patent:
June 19, 2001
Assignee:
Diagnostic Systems Laboratories, Inc.
Inventors:
M. Javad Khosravi, Anastasia Diamandi, Jehangir Mistry
Abstract: The present invention relates to screening or testing for insulin like growth factors, insulin like growth factor binding proteins and/or acid labile subunit by the use of a solid support. Blood is collected onto a solid support, such as paper, and subsequently the analytes of interest are extracted for testing.
Type:
Grant
Filed:
December 10, 1996
Date of Patent:
May 23, 2000
Assignee:
Diagnostic Systems Laboratories, Inc.
Inventors:
M. Javad Khosravi, Jehangir Mistry, Anastasia Diamandi
Abstract: The present invention is for an immunoassay for the measurement of total insulin-like growth factor binding protein-1 (IGFBP-1) and is unaffected by the degree of phosphorylation of the protein. The invention is also for an immunoassay for assessing the phosphorylated variants of IGFBP-1.
Type:
Grant
Filed:
May 7, 1996
Date of Patent:
May 5, 1998
Assignee:
Diagnostic Systems Laboratories, Inc.
Inventors:
M. Javad Khosravi, Jehangir Mistry, Anastasia Diamandi