Abstract: An RFID-based anemia detection sensor that integrates a paper-based diagnostic device with a passive Ultra High Frequency (UHF) RFID tag. Differences in red blood cell (RBC) count in a patient's blood manifests itself as a controlled time-dependent change in the tag's signal response. In one embodiment, the sensor is capable of reliably differentiating between blood having 20, 30, 40 and 50 percent RBC concentration by volume, which is indicative of anemic vs. healthy blood. In another embodiment, the sensor is read using standard RFID equipment allowing for large-scale automated screening of blood specimens.
Type:
Application
Filed:
April 14, 2017
Publication date:
April 25, 2019
Applicants:
Massachusetts Institute of Technology, Diagnostics for All, Inc.
Inventors:
Sanjay E. Sarma, Rahul Bhattacharyya, Christina D. Swanson
Abstract: The invention provides molecular diagnostic test devices and methods for using such diagnostic test devices to detect analytes of biological significance in a patient. The diagnostic test devices are particularly useful for detecting a polynucleotide analyte in a sample obtained from a patient. Further, the diagnostic test devices are inexpensive, disposable, easy to use, and are useful at the point of care.
Abstract: Described herein are disposable paper-based assay devices for detection and quantitation of analytes in liquid clinical samples, e.g., blood or urine. The devices may be particularly suitable for use in regions of the world where health care infrastructure is absent. The test devices are versatile in that they can be adapted to detect a variety of analytes. The devices are also easy to use and interpret. Typically, all that is needed to conduct an assay is to apply a drop of sample to the indicated location on the device. The devices are typically colorimetric and readable with the naked eye.