Patents Assigned to Diagnostics, Inc.
  • Test apparatus and methods for ST2 cardiac biomarker
    Patent number: 11525828
    Abstract: The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a blood plasma sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad disposed along a length of the base and is configured to hold the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The conjugate pad is further configured to receive the blood plasma sample. The test strip also includes a plurality of second and third antibodies that bind to ST2, and the conjugate-ST2 complexes, respectively. The plurality of second antibodies are bound to a membrane in a test location and the plurality of third antibodies are bound to the membrane in a control location.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 13, 2022
    Assignee: Critical Care Diagnostics, Inc.
    Inventors: James V. Snider, Jillian Elizabeth Bender, Shrin P. Kuo, Roy A. Chung
  • Compounds and methods for use in detecting gabapentin
    Patent number: 11525835
    Abstract: Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: December 13, 2022
    Assignee: ARK Diagnostics, Inc.
    Inventors: Johnny Jose Valdez, Byung Sook Moon, Michael Kevin Helms, Alejandro A. Orozco
  • COMPOSITIONS, DEVICES, AND METHODS OF MITIGATING LIPOPROTEIN INTERFERENCE IN IN VITRO DIAGNOSTIC ASSAYS FOR HYDROPHOBIC ANALYTES
    Publication number: 20220387994
    Abstract: Methods of mitigating lipoprotein interference in in vitro diagnostic assays for target hydrophobic analytes are disclosed, as well as compositions, kits, and devices useful in said methods. A pretreatment reagent is utilized that includes at least one enzyme that digests lipoprotein.
    Type: Application
    Filed: May 12, 2022
    Publication date: December 8, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Tie Wei, Jie Li, Yun Yue
  • SYSTEMS, APPARATUS, AND METHODS OF ANALYZING SPECIMENS
    Publication number: 20220390936
    Abstract: A method of analyzing a specimen includes detecting a specimen integrity error in the specimen; capturing an image of the specimen; sending the image of the specimen to a customer support center at a remote location; analyzing the image of the specimen at the customer support center; and determining a cause of the specimen integrity error in response to analyzing the image of the specimen. Diagnostic analyzers and diagnostic systems are also disclosed.
    Type: Application
    Filed: October 29, 2020
    Publication date: December 8, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Muhammad Ahmed
  • METHODS AND APPARATUS PROVIDING CALIBRATION OF FOREGROUND ILLUMINATION FOR SAMPLE CONTAINER CHARACTERIZATION
    Publication number: 20220390478
    Abstract: A method of calibrating an imaging device adapted to characterize a feature of a sample container, such as a cap color or cap type. The method includes providing a calibration tube including an imaging surface at an imaging location of a first imaging apparatus; illuminating the imaging surface with light emitted from multiple front light sources; adjusting a drive current to each of the multiple front light sources to establish a substantially uniform intensity of the imaging surface; recording drive current values for the multiple front light sources; replacing the calibration tube with a calibration tool having a calibration surface of a known reflectance; and measuring target intensity values of the calibration tool at the respective drive current values. Calibration tools, imaging apparatus, quality check modules, and health check methods are provided, as are other aspects.
    Type: Application
    Filed: October 22, 2020
    Publication date: December 8, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Yao-Jen Chang, Patrick Wissmann, Ludwig Listl, Benjamin S. Pollack, Ramkrishna Jangale, Rayal Raj Prasad Nalam Venkat, Venkatesh NarasimhaMurthy, Ankur Kapoor
  • Basin and high speed air solution
    Patent number: 11517948
    Abstract: One embodiment provides a rinse basin and blower system configured to clean a pipette including: a rinse basin comprising: a hollow tube enclosed at one end; wherein the hollow tube comprises an upper port and a lower port; and the lower port being tapered toward the hollow tube; and wherein the rinse basin is connected to a blower system; the blower system comprising: a waste reservoir that receives, from the rinse basin, a waste product comprising: air and liquid, wherein the waste reservoir separates the liquid from the air; a dryer that receives the air from the waste reservoir and further separates any remaining liquid from the air; and a blower that receives the air from the dryer and exhausts the air.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 6, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Viatcheslav Pronkine, Dimitri Shishkin, Shriram Patel
  • Short aspiration detection in a clinical analyzer
    Patent number: 11519771
    Abstract: One embodiment provides a method for detecting aspiration in a clinical analyzer, including: acquiring, from a sensor, pressure measurement data; transforming the pressure measurement data into frequency domain data; generating a clean version of the frequency domain data by attenuating, using a filter, unwanted frequencies; comparing the cleaned version of the frequency domain data to one or more predetermined data points; and determining, based on the comparison, if an aspiration was properly performed. Other aspects are described and claimed herein.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: December 6, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: William D. Dunfee, Stephen Krufka, Mark H. Sprenkle, Colin Ingersoll
  • APPARATUS AND METHODS OF ANALYZING DIAGNOSTIC TEST ORDERS
    Publication number: 20220384051
    Abstract: A method of analyzing diagnostic test orders includes analyzing diagnostic test orders from a plurality of medical providers; identifying a peer group of medical providers having one or more like characteristics from the plurality of medical providers; and determining whether at least one diagnostic test order includes an outlier test. One or more medical providers may be notified of the presence of an outlier test (a test ordered by, or not ordered by, the peer group). Other methods, apparatus, and systems are disclosed.
    Type: Application
    Filed: October 9, 2020
    Publication date: December 1, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael Heydlauf
  • APPARATUS AND METHODS OF TRAINING MODELS OF DIAGNOSTIC ANALYZERS
    Publication number: 20220383618
    Abstract: A method of training a model of a diagnostic apparatus includes providing one or more first tube assemblies of a first type and one or more second tube assemblies of a second type in a diagnostic apparatus; capturing one or more first images of at least a portion of each of the one or more first tube assemblies and the second tube assemblies using the imaging device. Training the model includes identifying tube assemblies of the first type and tube assemblies of the second type based on the one or more first images and the one or more second images. Tubes assemblies of the first type are grouped into a first group and tube assemblies of the second type are grouped into a second group. Other methods and apparatus are disclosed.
    Type: Application
    Filed: October 22, 2020
    Publication date: December 1, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Rayal Raj Prasad Nalam Venkat, Benjamin S. Pollack, Yao-Jen Chang, Venkatesh NarasimhaMurthy, Vivek Singh, Ankur Kapoor
  • ROTARY PLATFORM FOR CELL LYSING AND PURIFICATION AND METHOD OF USE
    Publication number: 20220379300
    Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.
    Type: Application
    Filed: August 8, 2022
    Publication date: December 1, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jason Bryant, Eric Yeaton, Dan Harris, Josiah Hackendorf, Steven Allen, Mark Talmer
  • Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2)
    Patent number: 11512352
    Abstract: Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 29, 2022
    Assignee: Athena Diagnostics, Inc.
    Inventors: Corey D. Braastad, Narasimhan Nagan, Jeffrey G. Jones, William K. Seltzer, Susan K. Allen, Sat Dev Batish, Hui Zhu
  • Redundant power management for modular IVD analyzer vessel mover subsystem
    Patent number: 11515722
    Abstract: A modular in vitro diagnostics (IVD) vessel mover system providing redundant power management includes a plurality of modules which are configured to provide storage to one or more IVD samples. Each module comprising a power failover switch which is configured to receive internal power from an internal primary power source and transmit backup power to one or more of the plurality of modules.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 29, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Charles V. Cammarata, Thomas J. Bao
  • PHOTOCURABLE REAGENT(S) FOR FORMING CHLORIDE ION-SELECTIVE SENSOR(S) AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20220373500
    Abstract: Improved formulation(s), device(s), and method(s) for producing ion-selective electrodes (ISEs) that comprise at least one photo-curable, epoxy-based, ion-selective chloride membrane(s) compounds that can be pre-mixed together to form a singularly-dispensed mixture for the formation of an ion-exchange resin membrane(s) for incorporation and use in a chloride ISE.
    Type: Application
    Filed: October 30, 2020
    Publication date: November 24, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Kyoung Ha Cha, Zhu Teng, Si Yang
  • METHODS OF MANUFACTURING A HIGH MOLECULAR WEIGHT HEPARIN COMPOUND
    Publication number: 20220362283
    Abstract: A method of manufacturing a high molecular weight heparin (HMWH) compound is disclosed. The method comprises dissolving heparin to form a heparin solution and fractionating the heparin solution via tangential flow filtration (TFF) using a membrane with a molecular weight cut off (MWCO) between about 8 kDa and about 12 kDa. The TFF yields a retentate comprising fractionated heparin with a weight average molecular weight of about 20 kDa or greater, i.e., a high molecular weight heparin compound. A substantial proportion of heparin chains in the fractionated heparin may have a high molecular weight, e.g., 50% of the heparin chains or greater may have a molecular weight of 20 kDa or greater.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 17, 2022
    Applicant: NexEos Diagnostics, Inc.
    Inventors: Li Fu, Zhenyu Wang, Jessica Pax
  • COMPOSITIONS AND ARTICLES COMPRISING (NANO)DIAMOND PARTICLES
    Publication number: 20220362399
    Abstract: Compositions and articles comprising diamond particles, such as nanodiamond based pharmaceutical compositions, are generally provided. In some embodiments, the articles and methods comprising (nano)diamond particles may be useful for monitoring and/or treating a disease (e.g., in a subject).
    Type: Application
    Filed: May 24, 2022
    Publication date: November 17, 2022
    Applicant: Debina Diagnostics, Inc.
    Inventors: Giora Z. Feuerstein, Mark E. Sternberg
  • Methods and apparatus to calibrate a positional orientation between a robot gripper and a component
    Patent number: 11498217
    Abstract: Methods of calibrating a position of a component include providing a robot with a gripper and crush and crash sensors, a calibration tool coupled to the gripper, and the component, which has a recess and a crush zone. The methods also include moving the gripper in a first direction to sense contact between the calibration tool and the crush zone, recording the contact position, and moving the gripper to insert the tool into the recess. The gripper is then moved in second directions to sense contact between the tool and the recess and moved in third directions to also sense contact between the tool and the recess. The methods further include recording and processing the contact positions to determine a surface location in the first direction and a physical center of the recess. Robot calibration apparatus for performing the method is also disclosed, as are other aspects.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: November 15, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Benjamin S. Pollack, Steven Pollack
  • Methods and apparatus for rapid heating of biological specimens
    Patent number: 11498076
    Abstract: Methods of pre-heating a test vessel prior to transfer of the test vessel to an incubator may shorten an incubation cycle, ensure proper temperature of a test specimen in the test vessel, and/or improve testing accuracy and/or throughput in a bio-liquid specimen testing apparatus. The methods include providing a test vessel pre-heating apparatus having a receptacle sized to receive a test vessel therein and having at least one heating unit configured to heat by direct conduction at least one side of the test vessel. The methods also include heating at least one side of the test vessel via direct contact using the at least one heating unit. Specimen testing apparatus and test vessel pre-heating apparatus configured to carry out the method are described, as are other aspects.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 15, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Paul Dulaff, Christopher Delametter
  • System for detecting infection in synovial fluid
    Patent number: 11499970
    Abstract: The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 15, 2022
    Assignee: CD Diagnostics, Inc.
    Inventors: Carl Deirmengian, Richard C. Birkmeyer, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, Eun Kyung Chung
  • DEVICE AND METHOD TO EVALUATE A FLUID SAMPLE ON A SINGLE-USE MULTIANALYTE CONSUMABLE
    Publication number: 20220357347
    Abstract: Single-use diagnostic consumables for use in performing multiple analyses on a fluid sample are provided. The diagnostic consumables include a first sensing region configured for analysis of at least one analyte in a fluid sample that has been received by the diagnostic consumable. The diagnostic consumable further includes a fluid transport material configured to flow a portion of the fluid sample into a second sensing region fluidically connected to the fluid transport material and configured for performing a second analysis of the fluid sample. Methods for performing multiple analyses of a fluid sample on a single-use diagnostic consumable are also provided.
    Type: Application
    Filed: August 27, 2020
    Publication date: November 10, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Methods and Devices for Obtaining Cellular and DNA Material from Human Female Reproductive System
    Publication number: 20220356507
    Abstract: Efficient harvesting of cells, cell fragments, free nuclei, and DNA material from female reproductive system is made possible by processing gelatinous part of cervical mucus. Rinsing may be used to separate the gelatinous part of cervical mucus from the remainder of the cervical mucus sample.
    Type: Application
    Filed: December 17, 2021
    Publication date: November 10, 2022
    Applicant: Inanna Diagnostics, Inc.
    Inventor: Maya Tevlin