Patents Assigned to Diakron Pharmaceuticals, Inc.
  • Extended release formulation of a direct thrombin inhibitor
    Patent number: 10016417
    Abstract: Extended release formulations of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide (DPOC-4088) that provide for better control of blood plasma levels. The extended release formulations maintain substantially constant plasma levels of the active ingredient for at least about 16 hours and provide for once-daily dosing.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: July 10, 2018
    Assignee: Diakron Pharmaceuticals, Inc.
    Inventors: Sankar Ramakrishnan, Elumalal Venkatesan, Jayanthi Suryakumar, Stephane Allard
  • EXTENDED RELEASE FORMULATION OF A DIRECT THROMBIN INHIBITOR
    Publication number: 20140309239
    Abstract: Extended release formulations of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide (DPOC-4088) that provide for better control of blood plasma levels. The extended release formulations maintain substantially constant plasma levels of the active ingredient for at least about 16 hours and provide for once-daily dosing.
    Type: Application
    Filed: November 6, 2012
    Publication date: October 16, 2014
    Applicant: Diakron Pharmaceuticals Inc.
    Inventors: Sankar Ramakrishnan, Elumalal Venkatesan, Jayanthi Suryakumar, Stephane Allard
  • Process for the preparation of pyrazinone thrombin inhibitor and its intermediates
    Patent number: 8541580
    Abstract: Improved process for the preparation of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide of formula (I) and its intermediates is provided.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: September 24, 2013
    Assignee: Diakron Pharmaceuticals, Inc.
    Inventors: Reguri Buchi Reddy, Upparapalli Sampathkumar, Nilam Sahu, Jawaji Karunakara Rao, Gade Brahma Reddy
  • Calcium channel blockers
    Patent number: 8106062
    Abstract: The present invention is directed in part towards methods of modulating the function of calcium channels with dihydropyrimidine, dihydropyrimidone, dihydropyrimidinethione, and dihydropyridine compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to T-channel agonists that have a slow onset of activity and long duration of activity.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: January 31, 2012
    Assignee: Diakron Pharmaceuticals, Inc.
    Inventors: Jeffrey A. Bibbs, Srirama Rao
  • PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES
    Publication number: 20110105753
    Abstract: Improved process for the preparation of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide of formula (I) and its intermediates is provided.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 5, 2011
    Applicant: Diakron Pharmaceuticals, Inc.
    Inventors: Reguri Buchi Reddy, Upparapalli Sampathkumar, Nilam Sahu, Jawaji Karunakara Rao, Gade Brahma Reddy
  • Anti-diabetic and cholesterol lowering preparation from fenugreek seeds
    Patent number: 7815946
    Abstract: The invention relates to a composition having blood glucose-lowering and cholesterol-lowering activity that can be obtained from seeds of the Papilinaceae Leguminosae family, for example, fenugreek seed. Methods of obtaining the composition from seed and seed parts are provided. Therapeutic methods of using the composition, such as for treating diabetes and hypercholesterolemia, are also a part of the invention.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: October 19, 2010
    Assignee: Diakron Pharmaceuticals, Inc.
    Inventors: Pothapragada Suryanarayana Murthy, Radha Moorthy, K. M. Prabhu, Dinesh Puri
  • METHOD OF TREATMENT OF CARDIAC AND/OR RENAL FAILURE USING A CALCIUM CHANNEL BLOCKER AND AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR OR AN ANGIOTENSIN II RECEPTOR BLOCKER
    Publication number: 20090118334
    Abstract: A pharmaceutical composition including a calcium channel blocker and an angiotensin II receptor blocker or an angiotensin converting enzyme inhibitor. Also disclosed is a method of treating cardiovascular disease or renal disease by identifying a patient in need of such treatment, and administering a pharmaceutical composition disclosed herein to said patient.
    Type: Application
    Filed: January 9, 2009
    Publication date: May 7, 2009
    Applicant: Diakron Pharmaceuticals, Inc.
    Inventors: Howard C. Dittrich, Lauren Otsuki, Kenneth J. Widder
  • Pharmaceutical compositions for lowering blood glucose and blood cholesterol levels
    Patent number: 7338941
    Abstract: Methods of treating a mammal with high blood-glucose, or high blood-cholesterol, levels with isovitexin, and pharmaceutical compositions comprising the same are disclosed.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: March 4, 2008
    Assignee: Diakron Pharmaceuticals, Inc.
    Inventors: Jeffrey A. Bibbs, Srirama Rao