Patents Assigned to Diatech, Inc.
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Patent number: 5932189Abstract: This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, and radiodiagnostic reagents and peptides. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods for using such peptides for radiodiagnostic and radiotherapeutic purposes.Type: GrantFiled: July 29, 1994Date of Patent: August 3, 1999Assignee: Diatech, Inc.Inventors: Richard T. Dean, William McBride, John Lister-James
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Patent number: 5788960Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99 m for such imaging. The invention provides peptides which bind technetium-99 m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: June 5, 1995Date of Patent: August 4, 1998Assignee: Diatech, Inc.Inventor: Richard T. Dean
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Patent number: 5620675Abstract: This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to linear peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to linear peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention so specifically relates to liner peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provide.Type: GrantFiled: July 21, 1993Date of Patent: April 15, 1997Assignee: Diatech, Inc.Inventors: William McBride, Richard T. Dean
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Patent number: 5561220Abstract: This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also provides methods for producing and using such compositions. Specifically, the invention relates to compositions comprised of technetium-99m (Tc-99m) labeled scintigraphic imaging agents comprising a polybasic compound having at least 5 chemical functionalities that are basic at physiological pH and a radiolabel-binding moiety, the composition further comprising a polysulfated glycan, the composition being capable of specifically binding to inflammatory sites in vivo. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body, are also provided.Type: GrantFiled: June 7, 1993Date of Patent: October 1, 1996Assignee: Diatech, Inc.Inventors: Richard T. Dean, Brian R. Moyer
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Patent number: 5552525Abstract: This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled peptides that specifically bind to inflammatory sites in vivo, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: February 19, 1993Date of Patent: September 3, 1996Assignee: Diatech Inc.Inventor: Richard T. Dean
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Patent number: 5508020Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via Tc-99m binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.Type: GrantFiled: June 5, 1992Date of Patent: April 16, 1996Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James
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Patent number: 5443815Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: November 27, 1991Date of Patent: August 22, 1995Assignee: Diatech, Inc.Inventors: Richard T. Dean, William McBride, Scott Buttram
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Patent number: 5405597Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: November 17, 1992Date of Patent: April 11, 1995Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram
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Patent number: 5225180Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are directly labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: September 10, 1991Date of Patent: July 6, 1993Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram