Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
Type:
Grant
Filed:
July 15, 2022
Date of Patent:
February 25, 2025
Assignee:
DICE ALPHA, INC.
Inventors:
Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter Van Der Linden, Timothy J. Church, Claudio Aquino, Margot Paulick
Abstract: Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.
Type:
Grant
Filed:
February 6, 2020
Date of Patent:
September 20, 2022
Assignee:
DICE ALPHA, INC.
Inventors:
Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter Van der Linden, Timothy J. Church, Claudio Aquino, Margot Paulick
Abstract: The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.
Type:
Grant
Filed:
December 11, 2020
Date of Patent:
March 15, 2022
Assignee:
DICE ALPHA, INC.
Inventors:
Paul R. Fatheree, Martin S. Linsell, John R. Jacobsen, Wouter A. Van Der Linden, Timothy J. Church, Claudio Aquino, Margot G. Paulick