Patents Assigned to Dideco S.p.A.
  • Patent number: 6899693
    Abstract: A pulsating pumping unit for a fluid, particularly blood, includes means suitable to draw the fluid from an intake connector in order to send it to a outlet connector. The means are contained in an enclosure provided with valves connected to the inlet and the outlet. The valve connected to the outlet has at least one duct passing through the wall of the enclosure, is open at the end that leads into the portion of space. The pumping unit has a flow control element comprising a band of elastic material fixed to the outer wall of the enclosure at the edges, so as to have a blind portion which faces the exit port of the duct and a portion provided with holes which faces the outer wall.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: May 31, 2005
    Assignee: Dideco S.p.A.
    Inventors: Nicola Ghelli, Fabrizio Mastrantonio, Ivo Panzani
  • Publication number: 20040173540
    Abstract: A method and apparatus for controlling the washing step in a blood centrifugation cell in which washing solution is introduced into the blood centrifugation cell and the cell contains compacted red cells and supernatant at the beginning of the washing step. The apparatus can comprise various sensors and a computer. The sensors sense and transmit to the computer three inputs. The first input is indicative of the total volume of blood that enters the cell during the filling step and the total amount of washing solution that enters the cell during the washing step. The second input is indicative of the hematocrit value of the blood introduced during the filling step. The third input is indicative of the geometric characteristics of the cell. Based on the inputs, the computer executes an algorithm that produces a first output that is the concentration of the supernatant in the supernatant-washing solution mixture.
    Type: Application
    Filed: March 19, 2004
    Publication date: September 9, 2004
    Applicant: Dideco S.p.A.
    Inventors: Ivo Panzani, Sergio Romagnoli, Massimo Belloni
  • Publication number: 20040175292
    Abstract: A device for oxygenating blood in an extracorporeal circuit includes a first structure suitable to delimit a portion of space-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space between an intake connector, which is connected to a venous line of the extracorporeal circuit, and a delivery connector. The device includes a second structure monolithically connected and contiguous to the first structure. The second structure is suitable to contain blood filtration means that divide the portion of space delimited thereby into a blood distribution chamber, provided with an air vent and connected to the delivery connector of the first structure, and a blood collection chamber provided with a delivery connector connected to the arterial line of the extracorporeal circuit.
    Type: Application
    Filed: March 19, 2004
    Publication date: September 9, 2004
    Applicant: Dideco S.p.A.
    Inventors: Nicola Ghelli, Edgardo Costa Maianti, Ivo Panzani
  • Patent number: 6770048
    Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: August 3, 2004
    Assignee: Dideco S.p.A.
    Inventor: Massimo Fini
  • Patent number: 6731379
    Abstract: A device for determining the concentration of heparin in a fluid sample comprising: a container for holding the fluid sample; a container for holding the dye solution; a mixer for mixing the fluid sample and the dye solution; an illumination source for illuminating a mixture comprising the fluid sample and the dye solution with electromagnetic radiation having a substantially continuous range of wavelengths in the visible range; a detector for detecting the absorption spectrum of the mixture within the substantially continuous range of wavelengths; a recorder for recording the absorption spectrum of the mixture within the substantially continuous range of wavelengths; and a calculator for calculating a spectral parameter.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: May 4, 2004
    Assignee: Dideco S.p.A.
    Inventors: Giuseppe Caputo, Raffaele Castelli, Elena Comoglio, Leopoldo Della Ciana, Arnaldo Giannetti
  • Patent number: 6723283
    Abstract: A device for oxygenating blood in an extracorporeal circuit includes a first structure suitable to delimit a portion of space-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space between an intake connector, which is connected to a venous line of the extracorporeal circuit, and a delivery connector. The device includes a second structure monolithically connected and contiguous to the first structure. The second structure is suitable to contain blood filtration means that divide the portion of space delimited thereby into a blood distribution chamber, provided with an air vent and connected to the delivery connector of the first structure, and a blood collection chamber provided with a delivery connector connected to the arterial line of the extracorporeal circuit.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: April 20, 2004
    Assignee: Dideco S.p.A.
    Inventors: Nicola Ghelli, Edgardo Costa Maianti, Ivo Panzani
  • Patent number: 6716151
    Abstract: A method and apparatus for controlling the washing step in a blood centrifugation cell in which washing solution is introduced into the blood centrifugation cell and the cell contains compacted red cells and supernatant at the beginning of the washing step. The apparatus can comprise various sensors and a computer. The sensors sense and transmit to the computer three inputs. The first input is indicative of the total volume of blood that enters the cell during the filling step and the total amount of washing solution that enters the cell during the washing step. The second input is indicative of the hematocrit value of the blood introduced during the filling step. The third input is indicative of the geometric characteristics of the cell. Based on the inputs, the computer executes an algorithm that produces a first output that is the concentration of the supernatant in the supernatant-washing solution mixture.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: April 6, 2004
    Assignee: Dideco S.p.A.
    Inventors: Ivo Panzani, Sergio Romagnoli, Massimo Belloni
  • Publication number: 20040027557
    Abstract: A device for determining the concentration of heparin in a fluid sample comprising: a container for holding the fluid sample; a container for holding the dye solution; a mixer for mixing the fluid sample and the dye solution; an illumination source for illuminating a mixture comprising the fluid sample and the dye solution with electromagnetic radiation having a substantially continuous range of wavelengths in the visible range; a detector for detecting the absorption spectrum of the mixture within the substantially continuous range of wavelengths; a recorder for recording the absorption spectrum of the mixture within the substantially continuous range of wavelengths; and a calculator for calculating a spectral parameter.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 12, 2004
    Applicant: Dideco S.p.A.
    Inventors: Giuseppe Caputo, Raffaele Castelli, Elena Comoglio, Leopoldo Della Ciana, Arnaldo Giannetti
  • Patent number: 6632190
    Abstract: An intraoperative autotransfusion system and method of use. The system includes an autotransfusion device, a removable cassette, a cardiotomy reservoir, a container for holding washing fluid, and a reservoir for containing processed blood. The removable cassette includes a centrifugal cell, a peristaltic pump, and multiple clamps, each having fixed and sliding elements. The cassette has a housing and multiple ducts for connection to the cardiotomy reservoir.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: October 14, 2003
    Assignee: Dideco S.p.A.
    Inventors: Giampaolo Simonini, Francesco Benatti
  • Patent number: 6630989
    Abstract: A method for determining the concentration of heparin in a fluid sample comprising: (a) providing a fluid sample containing heparin; (b) adding to the fluid sample a solution of a dye to form a mixture of sample and dye, wherein the dye interacts with the heparin in the sample so that the absorption spectrum of the mixture of sample and dye in the visible range varies as a result of the interaction in a manner quantitatively dependent on the heparin concentration; (c) determining the absorption spectrum in the visible range of the mixture of sample and dye; and (d) calculating a spectral parameter representative of both the reduction in the absorption of the free dye in solution and the increase in the absorption of the dye-heparin complex, the value of the spectral parameter being indicative of the concentration of heparin present in the fluid sample, in order to determine the concentration of heparin present in the fluid sample.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: October 7, 2003
    Assignee: Dideco S.p.A.
    Inventors: Giuseppe Caputo, Raffaele Castelli, Elena Comoglio, Leopoldo Della Ciana, Arnaldo Giannetti
  • Publication number: 20030055370
    Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.
    Type: Application
    Filed: October 15, 2002
    Publication date: March 20, 2003
    Applicant: Dideco S.p.A.
    Inventor: Massimo Fini
  • Patent number: 6475176
    Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: November 5, 2002
    Assignee: Dideco, S.p.A.
    Inventor: Massimo Fini
  • Patent number: 6416456
    Abstract: A method and an apparatus for the automatic control of a blood centrifuge, including a controller that processes four input values and two output parameters. The four input values include the hematocrit value of the input blood, the volume of the red cells present in the centrifuge, the filling level of the centrifuge, and, selectively, the hematocrit value for collected blood at the end of the filling step and the time required for the filling step. The two output parameters include the flow rate of the blood into the centrifuge and either the time required for the filling step (when the hematocrit value is provided as input) or the predicted hematocrit value (when the time for the filling step is provided as input).
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: July 9, 2002
    Assignee: Dideco S.p.A.
    Inventors: Andrea Zanella, Massimo Belloni, Guido Comai, Ivo Panzani
  • Publication number: 20020032399
    Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.
    Type: Application
    Filed: September 11, 2001
    Publication date: March 14, 2002
    Applicant: Dideco S.p.A.
    Inventor: Massimo Fini
  • Publication number: 20010027157
    Abstract: A method and an apparatus for the automatic control of a blood centrifuge, including a controller that processes four input values and two output parameters. The four input values include the hematocrit value of the input blood, the volume of the red cells present in the centrifuge, the filling level of the centrifuge, and, selectively, the hematocrit value for collected blood at the end of the filling step and the time required for the filling step. The two output parameters include the flow rate of the blood into the centrifuge and either the time required for the filling step (when the hematocrit value is provided as input) or the predicted hematocrit value (when the time for the filling step is provided as input).
    Type: Application
    Filed: June 4, 2001
    Publication date: October 4, 2001
    Applicant: Dideco S.p.A.
    Inventors: Andrea Zanella, Massimo Belloni, Guido Comai, Ivo Panzani
  • Patent number: 6287270
    Abstract: A combined device having a reservoir for venous blood and a reservoir for cardiotomy blood is disclosed. The device is characterized in that the venous reservoir is separated from the cardiotomy reservoir by a partition which includes a plurality of apertures. The apertures are in fluid communication with a plurality of ducts and passageways which are configured to provide various modes of operation depending upon whether, for the particular surgical conditions, it is desired to mix venous and cardiotomy blood, or to isolate those blood pools from each other.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: September 11, 2001
    Assignee: Dideco, S.p.A.
    Inventor: Massimo Fini
  • Patent number: 6273355
    Abstract: A method and an apparatus for making tube bundles for various medical applications such as oxygenators, dialyzers, and heat exchangers is described. The tube bundle is suitable for use as a heat exchanger in, for example, a blood cardioplegia circuit. The winding apparatus axially winds a flexible tube around a winding core. The apparatus includes a tube shuttle, a shuttle driver and a core driver. The core driver rotates the winding core to distribute the tube on the winding core in layers.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: August 14, 2001
    Assignee: Dideco S.p.A.
    Inventors: Michael R. Van Driel, Russell Joseph, Tomas W. Perrino
  • Patent number: 6258321
    Abstract: An apparatus and a method for making a transfer device comprising a tube bundle. The transfer device is suitable for use as a heat exchanger in a blood cardioplegia circuit, for example. The apparatus axially winds a flexible tube around a winding core. The apparatus includes a winding core, a core rotating means, a tube bobbin, and a tube shuttle to guide the tube around the core. A shuttle rotating means rotates the tube shuttle around the core. The method of making the transfer device includes providing a winding core, winding a tube from end to end around the winding core, fitting the wound bundle into a housing, sealing the first and second ends of the housing using a potting material, cutting the ends of the bundle to expose a lumen within the tubes, and attaching a first end cap and a second end cap.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: July 10, 2001
    Assignee: Dideco S.p.A.
    Inventors: Michael R. Van Driel, Russell Joseph
  • Patent number: 6241649
    Abstract: A method and an apparatus for the automatic control of a blood centrifuge, including a controller that processes four input values and two output parameters. The four input values include the hematocrit value of the input blood, the volume of the red cells present in the centrifuge, the filling level of the centrifuge, and, selectively, the hematocrit value for collected blood at the end of the filling step and the time required for the filling step. The two output parameters include the flow rate of the blood into the centrifuge and either the time required for the filling step (when the hematocrit value is provided as input) or the predicted hematocrit value (when the time for the filling step is provided as input).
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: June 5, 2001
    Assignee: Dideco S.p.A.
    Inventors: Andrea Zanella, Massimo Belloni, Guido Comai, Ivo Panzani
  • Patent number: 6139836
    Abstract: A method and apparatus for the encapsulation of biologically active agents in red blood cells (RBCS) is disclosed. The method is characterized in that lysed and partially lysed RBCs are concentrated prior to the introduction of the biologically active agent. The resultant carrier RBCs are stable for an extended period of time under physiological conditions and can be used for the systemic or targeted delivery of therapeutically effective amounts of one or more biologically active agents to a patient.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: October 31, 2000
    Assignee: Dideco, S.p.A.
    Inventors: Mauro Magnani, Ivo Panzani, Leonardo Bigi, Andrea Zanella