Abstract: A method for collecting and processing remotely sensed imagery in order to achieve precise spatial co-registration (e.g., matched alignment) between multi-temporal image sets is presented. Such precise alignment or spatial co-registration of imagery can be used for change detection, image fusion, and temporal analysis/modeling. Further, images collected in this manner may be further processed in such a way that image frames or line arrays from corresponding photo stations are matched, co-aligned and if desired merged into a single image and/or subjected to the same processing sequence. A second methodology for automated detection of moving objects within a scene using a time series of remotely sensed imagery is also presented. Specialized image collection and preprocessing procedures are utilized to obtain precise spatial co-registration (image registration) between multitemporal image frame sets.

Abstract: Methods and systems for detecting a falling power line in a power transmission or distribution system are described. Electrical measurements at various points in the power distribution system are used to detect changes in a power line indicating that the conductor has broken or become disconnected. Upon detection, control mechanisms are used to deenergize the conductor while the conductor is falling and/or before it contacts the ground.

Abstract: The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded DNA binding proteins (SSBs), and the quantity of crowding agent employed.

Abstract: A wearable electronic device for proximity-based social and professional networking which features electronics and software for the passive automated local wireless exchange of personal and/or business information with other electronic devices is disclosed. In some embodiments, an electronic device includes a controller having an operations unit; a communication unit configured to receive and/or transmit data from a first external source; and a memory unit configured to communicate with the controller and receive and/or transmit data from the controller. The operations unit may be configured to determine if received data from the first external source meets a set threshold and wherein the operations unit may be configured to instruct communication unit to accept data that meets or exceeds said threshold. The communication unit may receive and transmit data from the first external source provided the external source is within a predetermined proximity.

Abstract: Disclosed herein, in certain instances, is a novel photovoltaic cell that uses unique microarchitectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional electrode.

Abstract: The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase PIM-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding PIM-1, and methods for enhancing the regenerative potential of stem cells in the heart.

Abstract: Disclosed herein, in certain embodiments, is a method of depositing a polymer onto a surface. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer solution onto the surface. Disclosed herein, in certain embodiments, is a method of manufacturing an electrode or diode. In some embodiments, the method comprises using a high electric field and a high frequency vibratory motion to deposit a polymer onto a surface. Further disclosed herein, in certain instances, is an electrode manufactured by any method disclosed herein. Further disclosed herein, in certain instances, is a diode manufactured by any method disclosed herein.

Abstract: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

Abstract: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundres of megabases in length.

Abstract: The invention provides compositions (e.g., kits) and methods for determine the number of bacteria and other microbes in samples having low concentrations of microbes, for use, e.g., in biological warfare defense, microbe detection and agricultural and environmental sciences.

Abstract: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.

Abstract: In alternative embodiments, the invention provides cell-permeable recombinant or synthetic proteins to modulate autophagy, including a Tat-Atg5K130R (inhibitor of autophagy) and a Tat-Beclin 1 (stimulant or activator of autophagy), and nucleic acids expressing them and methods for making and using them, e.g., to treat conditions and disorders responsive to autophagy modulation (e.g., where autophagy is dysregulated), including neurodegeneration, cystic fibrosis, cancer, heart failure, diabetes, obesity, sarcopenia, aging, ischemia/reperfusion, inflammatory disorders including Crohns, ulcerative colitis, biliary cirrhosis, lysosomal storage diseases, infectious diseases associated with intracellular pathogens including viruses, bacteria, and parasites such as Trypanosomes and malaria.

Abstract: In alternative embodiments, the invention provides computer-implemented methods comprising: (a) representing a plurality of Data Node Archive (DNA) data elements, or a plurality of non-deoxyribonucleic acid (non-DNA) data elements, in a model having a format or organization in accordance with (or equivalent to, or analogous to) a biological deoxyribonucleic acid (DNA) model format or equivalent thereof; or, (b) a computer-implemented method comprising a subset of, substantially all, or all of the steps as set forth in the flow chart of FIG. 7.

Abstract: The invention provides ruthenium-comprising catalysts, and methods of making and using them, for conjugating double bonds in polyunsaturated hydrocarbons, including polyunsaturated fatty acid derivatives, such as natural fats and oils which comprise (contain) more than one carbon to carbon double bond—where the double bonds are separated by, e.g., a methylene, ethylene or propylene or longer group. The invention provides compositions and methods for treating fats and oils comprising “interrupted” (e.g., “methylene-, ethylene- or propylene-interrupted”) double bonds to generate isomers with “conjugated” double bonds. The invention also provides compositions, and methods of making and using them, for making catalysts on a solid support. In one aspect, these catalysts are for alkene isomerization or exchange of alkene hydrogens for other isotopes.

Abstract: The present invention provides an interaction device adapted for setting own controller for maximizing expectation of information defined between a hypothesis about an interaction object and own input/output. Thus, the social robot can judge by using only simple input/output sensor whether or not the human being is present or absent at the outside world.

Abstract: This disclosure provides methods for Recombinase-Polymerase Amplification (RPA) of a target DNA. The methods exploit the properties of the bacterial RecA and related proteins to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the methods allow amplification of DNA up to hundreds of megabases in length.

Abstract: A method and system of managing a residential or commercial energy system is described. The method includes predicting power consumption of a building, scheduling one or more appliances sufficient to optimize a consumer's energy usage, collecting usage profiles and demand and re-calculating the predicting of power consumption of a building.

Abstract: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods. Further disclosed are conditions to enable real-time monitoring of RPA reactions, methods to regulate RPA reactions using light and otherwise, methods to determine the nature of amplified species without a need for gel electrophoresis, methods to improve and optimize signal to noise ratios in RPA reactions, methods to optimize oligonucleotide primer function, methods to control carry-over contamination, and methods to employ sequence-specific third ‘specificity’ probes.