Abstract: A unitary coiled connector component for use within a 3D bioprinter or cell printer. The unitary coiled connector comprising a metal sleeve, a PEEK insert, and a printer tip, and configured for connection to a valve within the cell printer. The unitary coiled connector being easily removable and replaceable to reduce repair time as well as reduce contamination to the cell printer during repair or replacement of the coiled connector. Also disclosed is an alternative embodiment of a printer block for retaining one or more unitary coiled connectors.

Abstract: The present invention is in the field of pharmaceutical research tools. Specifically, the present invention provides methods for screening compounds or compositions with respect to their ability and/or specificity to modulate the activity of proteases.

Abstract: A source for reducing drift of a hot spot by producing infrared (IR) light with an insulating housing; an electrical power supply; first and second resistance elements having first and second resistivities; a third resistance element having a third resistivity; the third resistance element disposed between the first and second resistance elements, with the resistivity of the third resistance element having a value greater than the resistivity of both the first and second resistance elements. Alternatively, the first and second resistance elements can have cross-sectional areas that are greater than that of the third resistance. A method of reducing drift of a hot spot in a radiating element of a source of IR illumination by applying constant polarity substantially constant direct current from the power supply and reversing polarity in less than 24 hours, by a square wave AC source, or a Class E amplifier at constant power.

Abstract: An adapter is interposed between the objective and the microscope. The adapter has a support structure to which are mounted an objective-engaging structure, a microscope-engaging structure, and a reflecting element. The objective-engaging structure and the microscope-engaging structure, when mounted to the support structure, are characterized by respective axes that are non-collinear, and the reflecting element is positioned and oriented so that light incident along the objective-engaging structure's axis is reflected to travel along the microscope-engaging structure's axis. The relative angle between the axes is preferably 90 degrees. A user mounts the adapter to the microscope and the objective to the adapter, at which point, the microscope is capable of viewing a sample at an angle displaced from the vertical. In the specific example of a 90-degree angle, a sample of any size can be viewed merely by bringing the sample beside the microscope and in front of the objective.

Abstract: This invention teaches a method to identify cellular abnormalities which are associated with disease states. The method utilizes infrared (IR) spectra of cell samples which are dried on an infrared-transparent matrix and scanned at the frequency range from 3000-950 cm−1. The identification of samples is based on establishing a reference using a representative set of spectra of normal and/or diseased specimens. During the reference assembly process, multivariate techniques such as Principal Component Analysis (PCA) and/or Partial Least Squares (PLS) are used. PCA and PLS reduce the data based on maximum variations between the spectra, and generate clusters in a multidimensional space representing the different populations. The utilization of Mahalinobis distances, or linear regression (e.g., Principle Component Regression on the reduced data from PCA) form the basis for the discrimination.