Patents Assigned to Dilafor AB
  • Processes for the production of chemically-modified heparins
    Patent number: 10023659
    Abstract: The present invention relates to a process for the production of heparin derivatives having an average molecular weight of from about 4.6 to about 6.9 kDa and an anti-factor Xa activity of less than about 10 IU/mg, comprising the steps of oxidation of unfractionated heparin, depolymerisation and reduction of resulting terminal groups.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: July 17, 2018
    Assignee: Dilafor AB
    Inventors: Per-Olov Eriksson, Erik Yngve Holmer
  • Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
    Patent number: 9475888
    Abstract: The present invention relates to a chemically modified glycosaminoglycan with an antifactor II activity of less than 10 IU/mg, an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw, weight average) from about 4.6 to 6.9 kDa. Also disclosed is a method of preparing the modified glycosaminoglycan and its medical uses.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: October 25, 2016
    Assignee: Dilafor AB
    Inventors: Hans-Peter Ekre, Ulf Lindahl, Erik Holmer, Per-Olov Eriksson
  • Use of sulfated glycosaminoglycans for establishing effective labor in women
    Patent number: 8524688
    Abstract: A method of treating protracted labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerized low molecular weight heparin treated with periodate to eradicate antithrombin III binding affinities, thereby exhibiting an anticoagulant activity of 10 BP units/mg or less and an average molecular weight not higher than 10000 Da to prime or curatively treat the cervix and myometrium and for treatment of slow progress of labor. A method for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerized low molecular weight heparin as described to prophylactically prime or curatively treat the cervix and myometrium and for establishing effective labor in the pregnant woman.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: September 3, 2013
    Assignee: Dilafor AB
    Inventors: Gunvor Ekman-Ordeberg, Anders Malmström
  • Use of Sulfated Glycosaminoglycans for Establishing Effective Labor in Women
    Publication number: 20120225843
    Abstract: A method of treating protracted labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerised low molecular weight heparin treated with periodate to eradicate antithrombin III binding affinities, thereby exhibiting an anticoagulant activity of 10 BP units/mg or less and an average molecular weight not higher than 10000 Da to prime or curatively treat the cervix and myometrium and for treatment of slow progress of labor. A method for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerised low molecular weight heparin as described to prophylactically prime or curatively treat the cervix and myometrium and for establishing effective labor in the pregnant woman.
    Type: Application
    Filed: May 9, 2012
    Publication date: September 6, 2012
    Applicant: DILAFOR AB
    Inventors: Gunvor EKMAN-ORDEBERG, Anders MALMSTRÖM
  • Use of sulfated glycosaminoglycans for establishing effective labor in women
    Patent number: 8207145
    Abstract: The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in women.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: June 26, 2012
    Assignee: Dilafor AB
    Inventors: Gunvor Ekman-Ordeberg, Anders Malmström
  • Use of sulfated glycosaminoglycans for establishing effective labor in women
    Patent number: 7407945
    Abstract: The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in women.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: August 5, 2008
    Assignee: Dilafor AB
    Inventors: Gunvor Ekman-Ordeberg, Anders Malmström