Patents Assigned to DINGFU BIOTARGET CO., LTD.
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Patent number: 11883503Abstract: Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.Type: GrantFiled: September 21, 2018Date of Patent: January 30, 2024Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Shilong Fu, Songbing Qin, Jian Ding, Kai Fu
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Patent number: 11845806Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: GrantFiled: June 13, 2018Date of Patent: December 19, 2023Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Kai Fu, Meng Zhao, Xiaoxiao Wang
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Patent number: 11795230Abstract: The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a KD of 10?8 M or less; activates and/or increases CD27 mediated NF-?B activity; stimulates CD4+ and/or CD8+ T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-? by CD4+ and/or CD8+ T cells. The present disclosure also provides a method for preparing and using said antibody.Type: GrantFiled: April 13, 2018Date of Patent: October 24, 2023Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Kai Fu
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Publication number: 20230241236Abstract: A composition including an immunoconjugate and a chemotherapeutic agent. The immunoconjugate includes 1) one or more interleukins, and 2) an Fc domain consisting of a first Fc subunit and a second Fc subunit. The first Fc subunit associates with the second Fc subunit to form a dimer. The one or more interleukins are fused to the Fc domain and the chemotherapeutic agent includes a fluorouracil and/or an oxaliplatin.Type: ApplicationFiled: June 28, 2021Publication date: August 3, 2023Applicant: DINGFU BIOTARGET, CO., LTD.Inventors: Ting XU, Kai FU, Jianjian PENG, Shilong FU, Jian DING, Liyao ZHOU
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Patent number: 11529425Abstract: Provided is an immunoconjugate useful in inhibiting tumor growth, and a composition and/or protein mixture comprising the immunoconjugate. Also provided are methods for the production of the immunoconjugate, as well as pharmaceutical uses of the immunoconjugate in inhibiting tumor growth, including but not limited to treatment of cancers.Type: GrantFiled: September 6, 2018Date of Patent: December 20, 2022Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Kai Fu, Yan Luan, Xiaojuan Liu, Jianjian Peng
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Publication number: 20220227827Abstract: Proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: ApplicationFiled: March 24, 2020Publication date: July 21, 2022Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Ting XU, Jianjian PENG, Kai FU, Shilong FU, Xiaolong PAN, Jian DING, Shanshan NING, Liyao ZHOU
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Patent number: 11357826Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.Type: GrantFiled: August 21, 2019Date of Patent: June 14, 2022Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Shuli Ma, Meng Zhao, Xiaoxiao Wang, Hui Ma, Shilong Fu, Xiaolong Pan, Shanshan Ning
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Publication number: 20210380708Abstract: An antibody may be capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. The antibody or antigen binding fragment thereof may be used in preparing a drug. The antibody or an antigen binding fragment thereof may specifically bind CD137, and may include a light chain variable region VL and a heavy chain variable region VH, wherein compared to a sequence as shown in SEQ ID NO: 103, the VL comprises one or more VL amino acid mutations, and the VL amino acid mutation occurs at one or more positions: V3, A10, K44, D71, and/or V77.Type: ApplicationFiled: September 12, 2019Publication date: December 9, 2021Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Xin ZHANG, Jianjian PENG, Kai FU, Hui MA, Xiaolong PAN, Shilong FU, Shuli MA, Jian DING
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Publication number: 20210179726Abstract: The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a KD of 10?8 M or less; activates and/or increases CD27 mediated NF-?B activity; stimulates CD4+ and/or CD8+ T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-? by CD4+ and/or CD8+ T cells. The present disclosure also provides a method for preparing and using said antibody.Type: ApplicationFiled: April 13, 2018Publication date: June 17, 2021Applicant: Dingfu Biotarget Co., Ltd.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Kai FU
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Patent number: 10875926Abstract: Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.Type: GrantFiled: September 22, 2015Date of Patent: December 29, 2020Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Yan Luan, Xiaoxiao Wang, Jianjian Peng, Shuli Ma, Hui Ma, Xiaolong Pan, Shilong Fu, Shanshan Ning, Yeqiong Fei, Meng Zhao
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Publication number: 20200354478Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: ApplicationFiled: June 13, 2018Publication date: November 12, 2020Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Kai FU, Meng ZHAO, Xiaoxiao WANG
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Patent number: 10624974Abstract: The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.Type: GrantFiled: October 15, 2015Date of Patent: April 21, 2020Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Yan Luan, Xiaoxiao Wang, Jianjian Peng, Shuli Ma, Hui Ma, Xiaolong Pan, Shilong Fu, Shanshan Ning, Yeqiong Fei, Meng Zhao
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Publication number: 20200069773Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.Type: ApplicationFiled: August 21, 2019Publication date: March 5, 2020Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Shuli MA, Meng ZHAO, Xiaoxiao WANG, Hui MA, Shilong FU, Xiaolong PAN, Shanshan NING
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Patent number: 10471124Abstract: The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: GrantFiled: November 10, 2015Date of Patent: November 12, 2019Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Shuli Ma, Meng Zhao, Xiaoxiao Wang, Hui Ma, Shilong Fu, Xiaolong Pan, Shanshan Ning