Abstract: The instant technology generally relates to a topical (e.g. transdermal) patch for delivery of an active agent. The patch comprises soluble, hydrophilic polycaprolactone (PCL) as a delivery substrate for an active agent of interest. Soluble, hydrophilic PCL can be formulated to adjust the degradation rate of the PCL, in order to deliver the active agent at a desired delivery rate.

Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyzes of DNA).

Abstract: Collection devices, kits and methods related to sample collection and analysis can be used to collect and store samples (e.g., biological samples) from a variety of sources and optionally, for analysis of such samples (e.g., forensics analysis, medical diagnostics, etc.). Methods of production and use thereof are described herein. A device for collecting a sample (e.g., a sample including nucleic acid) includes an outer protective housing and a collection tip operably coupled to a carrier. The collection tip includes a hydrophilic and at least partially soluble material (e.g., hydrophilic and at least partially soluble polycaprolactone (PCL)) and is movable (e.g., retractable) from a first protected position within the outer protective housing to a second collecting position outside the outer protective housing.

Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).

Abstract: A method and system to predict a design of an article of manufacture, which can include the steps of introducing a biological organism into a test environment to activate at least one molecular component of the biological organism representing at least one set of genetic characters of the biological organism; monitoring for change in at least one expression phenomenon pattern in response to the test environment; translating the monitored change in the at least one expression phenomenon pattern into a molecular data profile; interrogating the molecular data profile against a stored database to generate an information pattern of a phenotype correlated to the molecular data profile; and translating the information pattern of the phenotype into a correlated design component of the article of manufacture.

Abstract: An automated and integrated matching of a biological specimen to an individual, can include a collector having substrate materials and configured to selectively collect and release at least one bio-molecular species from a biological specimen; a self-contained mobile automated testing instrument configured to receive the biological specimen and further configured to generate, store and output a molecular profile of the at least one predetermined bio-molecular species; a processor based system communicatively coupled to the self-contained mobile automated testing instrument and configured to receive the molecular profile; and wherein the processor based system is configured to provide a quantitative comparative analysis and report of the molecular profile with a selected molecular profile.