Patents Assigned to Dionex Corporation
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Patent number: 9440166Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.Type: GrantFiled: August 30, 2012Date of Patent: September 13, 2016Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, SM Rahmat Ullah
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Patent number: 9424398Abstract: Methods, systems and GUIs for defining a sequence of analyzes for an analytical instrument using a workflow are described. A method includes receiving user inputs including workflow parameters for defining the sequence, and automatically defining the sequence for the analytical instrument based on the workflow parameters, including creating rules for the sequence. The rules are persistent for subsequent use of the sequence. The rules are defined by the user, e.g., an administrator, who creates or edits the workflow. The administrator can leave some choices available to operators who run the workflow, or can lock selections down.Type: GrantFiled: December 22, 2009Date of Patent: August 23, 2016Assignee: DIONEX CORPORATIONInventors: Fraser S. McLeod, Peter Sauter, Markus Roming
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Patent number: 9400268Abstract: An electrolytic method for suppressing liquid eluent containing previously separated sample analyte anions, counterions to the sample anions, and non-sample anions suppressible to weak acids in an electrolytic device comprising a housing defining at least a sample stream flow channel and an ion receiving flow-through channel separated by an ion exchange bather. The sample stream flow channel includes an upstream channel portion and a downstream channel portion. A first current is applied across the upstream channel portion for substantially completely suppression. A second current is applied across the downstream channel portion at a magnitude of less than 10% of the magnitude of the first current.Type: GrantFiled: August 8, 2014Date of Patent: July 26, 2016Assignee: DIONEX CORPORATIONInventors: Christopher A. Pohl, Kannan Srinivasan, Brittany Omphroy
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Patent number: 9375697Abstract: An extraction cell assembly includes a cell body, a cap assembly having a cap body and a cap insert, a bed support and a seal. The cap body is removably secured to the cell body and includes a throughbore and a peripheral wall. The cap insert includes a plunger, a peripheral flange extending outwardly from the plunger, and a recess disposed within the plunger. The flange and plunger of the cap insert are slidably received, respectively, inside the peripheral wall and throughbore of the cap body. The bed support is removably received within the recess. The seal is removably received within the throughbore. The seal forms a fluid seal between the cell body and the cap assembly when the cap assembly is secured to the cell body. A method of using the extraction cell assembly is also disclosed.Type: GrantFiled: March 12, 2014Date of Patent: June 28, 2016Assignee: DIONEX CORPORATIONInventors: Michael J. McAdams, Sm Rahmat Ullah, Kannan Srinivasan
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Patent number: 9340562Abstract: A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.Type: GrantFiled: October 29, 2014Date of Patent: May 17, 2016Assignees: Thermo Electron Manufacturing Limited, Dionex CorporationInventors: Xiaodong Liu, Richard T. Williams, Xiao Cui
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Patent number: 9329158Abstract: This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.Type: GrantFiled: March 15, 2013Date of Patent: May 3, 2016Assignee: DIONEX CORPORATIONInventors: Xiaodong Liu, Liang Cao, Christopher A. Pohl
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Patent number: 9322811Abstract: A fluidic connection system may comprise a port which includes a capillary tube receptacle with an end seal face and a threaded wall. The fluidic connection system may also comprise a capillary tube that includes a front end face for sealingly abutting against the end seal face of the port. On the capillary tube, a flange may be affixed at a distance from the front end face of the capillary tube. The fluidic connection system may further comprise a fitting nut that includes an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port. The fitting nut may be slidably coupled with the capillary tube behind the flange. The distance at which the flange is affixed may be predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.Type: GrantFiled: November 12, 2012Date of Patent: April 26, 2016Assignee: DIONEX CORPORATIONInventors: Michael John McAdams, Milton Liu, George N. Proper
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Patent number: 9322815Abstract: Ion chromatography apparatus including (a) a chromatographic column, (b) a source of an aqueous eluent liquid stream, (c) a detector, (d) a recycle line between the detector and the chromatographic column, and (e) a purifying device disposed along the recycle line including ion exchange removal medium. Also, such apparatus with an electrolytic purifying device disposed along the recycle line. Also, methods of using such apparatus.Type: GrantFiled: February 25, 2008Date of Patent: April 26, 2016Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Rong Lin, Sheetal Bhardwaj, Christopher A. Pohl
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Patent number: 9314712Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces).Type: GrantFiled: May 9, 2008Date of Patent: April 19, 2016Assignee: DIONEX CORPORATIONInventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen, L. Andy Woodruff
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Patent number: 9310344Abstract: The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.Type: GrantFiled: June 14, 2013Date of Patent: April 12, 2016Assignee: DIONEX CORPORATIONInventors: Xiaodong Liu, Christopher A. Pohl, Jinhua Chen
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Patent number: 9283494Abstract: A liquid chromatography agglomerated bed comprising component A comprising (a) substrate particles and polymer chains (e.g. a condensation polymer) bound to the substrate particles and projecting therefrom, and (b) component B comprising substrate particles having external surfaces of opposite charge to that of the charged polymer chains, components A and B being bound at least in part by electrostatic forces between the component A charged polymer chains and the component B external surfaces to form in composite an agglomerated bed of ion exchange particles packed in a chromatography column.Type: GrantFiled: September 16, 2005Date of Patent: March 15, 2016Assignee: DIONEX CORPORATIONInventors: Christopher A. Pohl, Charanjit Saini
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Patent number: 9283495Abstract: An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.Type: GrantFiled: March 6, 2013Date of Patent: March 15, 2016Assignee: DIONEX CORPORATIONInventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
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Patent number: 9216403Abstract: This invention provides aqueous-compatible, polar-embedded reversed-phase stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations.Type: GrantFiled: March 15, 2013Date of Patent: December 22, 2015Assignee: DIONEX CORPORATIONInventors: Xiaodong Liu, Liang Cao, Christopher A. Pohl
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Patent number: 9188573Abstract: An ion chromatography housing for easy insertion and removal of a plurality of component cartridges is disclosed. Various components of the IC system are provided in the separate component cartridges. The IC housing includes a capillary separation column and may be connected to conventional-scale components of an IC system. A plurality of IC housings may be provided in a compartment with one or more separation columns. The columns may be capillary columns or conventional-scale columns. A method of using the ion chromatography system is also disclosed. The IC system may be utilized to perform two-dimensional ion chromatographic separation.Type: GrantFiled: January 20, 2010Date of Patent: November 17, 2015Assignee: DIONEX CORPORATIONInventors: Yan Liu, Glenn Masami Kuse, Victor Barreto, Gary L. Gleave, Christopher A. Pohl, William Dale Case, Khosro Moshfegh, Michael John McAdams
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Publication number: 20150306518Abstract: An electrolytic device comprising a housing includes at least first and second adjacent liquid flow-through channels. A bather impermeable to ion flow and to bulk liquid flow is disposed between the first and second channels. A first electrode assembly is disposed adjacent to one end of the channels and a second electrode assembly is disposed adjacent the other end of the channels. Also, a contaminant removal method using the above electrolytic device. A first aqueous stream including contaminants flows through the first channel while passing a current between the first and second electrode assemblies to remove contaminants. Effluent from the first channel flows, with or without further treatment, through the second channel while passing current between said first and second electrode assemblies to remove further contaminants.Type: ApplicationFiled: April 23, 2014Publication date: October 29, 2015Applicant: DIONEX CORPORATIONInventor: Kannan Srinivasan
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Patent number: 9169331Abstract: An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.Type: GrantFiled: December 21, 2012Date of Patent: October 27, 2015Assignee: DIONEX CORPORATIONInventors: Xiaodong Liu, Udayanath Aich, Christopher A. Pohl
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Patent number: 9144756Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions provide both strong aromatic and hydrophobic interactions with components of a sample. Moreover, the invention provides compositions of new silanes, their immobilization on a solid substrate, such as silica, to form new stationary phases.Type: GrantFiled: May 19, 2011Date of Patent: September 29, 2015Assignee: Dionex CorporationInventors: Xiaodong Liu, Jinhua Chen, Christopher A. Pohl
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Patent number: 9132364Abstract: The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.Type: GrantFiled: February 26, 2010Date of Patent: September 15, 2015Assignee: Dionex CorporationInventors: Kannan Srinivasan, Christopher A. Pohl, Sheetal Bhardwaj, Rong Lin
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Publication number: 20150224473Abstract: A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cage carry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially in a Stöber or modified Stöber process.Type: ApplicationFiled: February 7, 2014Publication date: August 13, 2015Applicants: THERMO ELECTRON MANUFACTURING LIMITED, DIONEX CORPORATIONInventors: Kevin SKINLEY, Xiaodong LIU, Christopher A. POHL, Harald RITCHIE
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Patent number: D757957Type: GrantFiled: December 29, 2014Date of Patent: May 31, 2016Assignee: DIONEX CORPORATIONInventors: Khosro Moshfegh, Aung Hein, Licheng Tseng