Abstract: Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
Abstract: The invention provides a novel method for the preparation of intermediates useful in a process designed to obtain known 1,2,4-triaminobenzene compounds, and in particular a specific compound thereof having known anticonvulsant activity. Unlike known methods, the novel method does not require advance protection of the amino groups present on the substrate.
Type:
Application
Filed:
October 29, 2013
Publication date:
June 12, 2014
Applicant:
DIPHARMA FRANCIS S.r.I
Inventors:
Emanuele ATTOLINO, Roberto ROSSI, Marco ARTICO
Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine), its (S)-enantiomer, and novel intermediates useful in thei synthesis.
Type:
Application
Filed:
October 28, 2010
Publication date:
May 5, 2011
Applicant:
DIPHARMA FRANCIS S.r.I.
Inventors:
Simone Mantegazza, Pietro Allegrini, Emanuele Attolino
Abstract: Process for the preparation of 4-[1-oxo-4-[4-(hydroxyphenylmethyl)-1-piperidinyl]butyl]-?,?-dimethylbenzenacetic acid, which is an intermediate useful in the preparation of fexofenadine, by hydrating asymmetric alkynes.
Type:
Application
Filed:
January 25, 2010
Publication date:
September 9, 2010
Applicant:
DIPHARMA FRANCIS S.r.I.
Inventors:
Emanuele ATTOLINO, Lino Colombo, Ada Maria Zurlo, Marco Artico, Pietro Allegrini
Abstract: Process for the preparation of (R)-2-[[[3-methyl-4(2,2,2-trifluoroethoxy)-2-piridyl]methyl]sulfinyl]benzimidazole (Dexlansoprazole) and new intermediates useful in its preparation.
Abstract: A process for the preparation of (R)—N-propargyl-1-aminoindane, or a salt thereof, comprising reacting 1-indanone with propargylamine, in presence of a mixture of sodium borohydride and acetic acid, to obtain N-propargyl-1-aminoindane; and its conversion into (R)—N-propargyl-1-aminoindane or a salt thereof.
Type:
Application
Filed:
June 24, 2009
Publication date:
February 4, 2010
Applicant:
DIPHARMA FRANCIS S.r.I.
Inventors:
Pietro ALLEGRINI, Bruno Gaetano Romano', Emanuele Attolino, Marco Artico, Davide Rossi
Abstract: Process for preparing a compound of formula (I), or a salt thereof, comprising reacting of a compound of formula (II) wherein X and R are as herein defined; with a compound of formula (III) NH2OZ??(III) wherein Z is a hydroxy protecting group, in presence of a catalyst, to obtain a compound of formula (IV), or a salt thereof, removing the hydroxyl protecting group to obtain a compound of formula (V), or a salt thereof; converting a compound of formula (V), or a salt thereof, into a compound of formula (I), or a salt thereof; and, if desired, converting a compound of formula (I) into a salt thereof, or vice versa.
Abstract: A process for the preparation of oxazolidinone derivatives, in particular [(S)—N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide] (linezolid), and novel intermediates useful for the synthesis thereof.
Type:
Application
Filed:
December 11, 2008
Publication date:
June 18, 2009
Applicant:
Dipharma Francis S.r.I.
Inventors:
Lino Colombo, Pietro Allegrini, Marco Brusasca, Giuseppe D'Arienzo, Gabriele Razzetti