Patents Assigned to Dipharma Francis S.r.l.
  • PREPARATION OF A PHARMACEUTICAL INTERMEDIATE
    Publication number: 20230053759
    Abstract: The present disclosure provides a new procedure for preparing a key intermediate for active pharmaceutical ingredients useful in the treatment of diseases related to the central nervous system.
    Type: Application
    Filed: July 12, 2022
    Publication date: February 23, 2023
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Francesca Della Penna, Valeria Nori, Fabio Pesciaioli, Armando Carlone
  • Synthesis of glycoconjugate derivatives of a bile acid
    Patent number: 11401297
    Abstract: Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid of formula (I) are provided herein.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: August 2, 2022
    Assignee: DIPHARMA FRANCIS S.R.L.
    Inventors: Alessandro Restelli, Philipp Carboni, Gabriele Razzetti
  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20200339622
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: July 15, 2020
    Publication date: October 29, 2020
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • Method for preparing a farnesoid X receptor agonist
    Patent number: 10752654
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 25, 2020
    Assignee: Dipharma Francis S.R.L.
    Inventors: Gabriele Razzetti, Anna Iuliano, Luca Giannotti, Grazia Iannucci, Emanuele Attolino, Vittorio Lucchini, Renzo Graziosi
  • Method for preparing selegiline base
    Patent number: 10597351
    Abstract: The present invention relates to a process for the preparation of selegiline base, an irreversible and selective inhibitor of the MAO-B enzymes and which is used in the treatment of Parkinson's Disease.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: March 24, 2020
    Assignee: Dipharma Francis S.r.L.
    Inventors: Alessandro Restelli, Gabriele Razzetti, Alessandro de Marco
  • Intermediates and process for the preparation of a crystalline form of a topical anti-inflammatory agent
    Patent number: 10597410
    Abstract: The present invention relates to a process for the preparation of an inhibitor of phosphodiesterase 4, in particular of phosphodiesterase 4B (PDE4B), and intermediates useful for its preparation.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: March 24, 2020
    Assignee: DIPHARMA FRANCIS S.R.L.
    Inventors: Niccolo′ Santillo, Emanuele Attolino, Davide Brenna, Chiara Vladiskovic, Alessandro Lombardo, Gabriele Razzetti
  • INTERMEDIATES AND PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF A TOPICAL ANTI-INFLAMMATORY AGENT
    Publication number: 20190241585
    Abstract: The present invention relates to a process for the preparation of an inhibitor of phosphodiesterase 4, in particular of phosphodiesterase 4B (PDE4B), and intermediates useful for its preparation.
    Type: Application
    Filed: January 24, 2019
    Publication date: August 8, 2019
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Niccolo' Santillo, Emanuele Attolino, Davide Brenna, Chiara Vladiskovic, Alessandro Lombardo, Gabriele Razzetti
  • Process for the preparation of crystalline dexlansoprazole
    Patent number: 10370359
    Abstract: The present invention relates to a process for the preparation of anhydrous crystalline 2-(R)-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl]-1H-benzimidazole (dexlansoprazole).
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: August 6, 2019
    Assignee: DIPHARMA FRANCIS S.r.L.
    Inventors: Alessandro Restelli, Alessio Bove, Gabriele Razzetti
  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20190106455
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: April 3, 2017
    Publication date: April 11, 2019
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • METHOD FOR PREPARING SELEGILINE BASE
    Publication number: 20180208542
    Abstract: The present invention relates to a process for the preparation of selegiline base, an irreversible and selective inhibitor of the MAO-B enzymes and which is used in the treatment of Parkinson's Disease.
    Type: Application
    Filed: January 24, 2018
    Publication date: July 26, 2018
    Applicant: Dipharma Francis S.r.l..
    Inventors: Alessandro Restelli, Gabriele Razzetti, Alessandro de Marco
  • Process for the preparation of piperidine compounds
    Patent number: 9932321
    Abstract: The present invention relates to a process for the preparation of efinaconazole.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: April 3, 2018
    Assignee: Dipharma Francis S.R.L.
    Inventors: Emanuele Attolino, Davide Rossi, Gabriele Razzetti
  • METHOD FOR PREPARING AN ANTIFIBROTIC AGENT
    Publication number: 20180009753
    Abstract: The present invention relates to a process for the preparation of pirfenidone, an immunosuppressive drug developed for the treatment of idiopathic pulmonary fibrosis.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Emanuele ATTOLINO, Mauro MITTINO, Alessandro LOMBARDO, Alessandro RESTELLI
  • Isolation and purification of 6-aminocaproic acid
    Patent number: 9776953
    Abstract: The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: October 3, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Massimo Magnani, Enrico Brunoldi, Gabriele Razzetti, Alessandro Restelli
  • Antimuscarinic compound having a low content of impurities
    Patent number: 9751828
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: September 5, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Emanuele Attolino, Renzo Graziosi
  • Synthesis of an azasugar and the intermediates thereof
    Patent number: 9708263
    Abstract: Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: July 18, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Andrea Malvestiti, Enrico Brunoldi, Emanuele Attolino
  • Crystalline forms of an antidepressant compound
    Patent number: 9687484
    Abstract: The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: June 27, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Stefano Luca Giaffreda, Marco Curzi, Elena Dichiarante, Pietro Allegrini, Renzo Graziosi, Chiara Vladiskovic
  • AZIDOALKYLAMINE SALTS AND THEIR USE AS INTERMEDIATES
    Publication number: 20170101365
    Abstract: The present invention relates to azidoalkylamine salts of formula (I) with organic acids, a process for their preparation, and their use as intermediates in the preparation of active pharmaceutical ingredients or polymers, or as spacers useful in organis synthesis.
    Type: Application
    Filed: May 26, 2015
    Publication date: April 13, 2017
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Pietro ALLEGRINI, Gabriele RAZZETTI, Dario PASTORELLO
  • ISOLATION AND PURIFICATION OF 6-AMINOCAPROIC ACID
    Publication number: 20170036991
    Abstract: The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.
    Type: Application
    Filed: August 4, 2016
    Publication date: February 9, 2017
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Massimo MAGNANI, Enrico BRUNOLDI, Gabriele RAZZETTI, Alessandro RESTELLI
  • Process for the preparation of an antidepressant and the intermediates thereof
    Patent number: 9550743
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: January 24, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Luca Giannotti, Renzo Graziosi, Emanuele Attolino, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF PIPERIDINE COMPOUNDS
    Publication number: 20160376253
    Abstract: The present invention relates to a process for the preparation of efinaconazole.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Emanuele Attolino, Davide Rossi, Gabriele Razzetti