Patents Assigned to Discovery Laboratories, Inc.
-
Publication number: 20150297524Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.Type: ApplicationFiled: March 28, 2013Publication date: October 22, 2015Applicant: Discovery Laboratories, Inc.Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
-
Publication number: 20140158123Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.Type: ApplicationFiled: February 13, 2014Publication date: June 12, 2014Applicant: Discovery Laboratories, Inc.Inventors: Jan MAZELA, Christopher HENDERSON
-
Patent number: 8748396Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. A method of making lyophilized pulmonary surfactants is described.Type: GrantFiled: November 27, 2013Date of Patent: June 10, 2014Assignee: Discovery Laboratories, Inc.Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
-
Patent number: 8748397Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.Type: GrantFiled: November 27, 2013Date of Patent: June 10, 2014Assignee: Discovery Laboratories, Inc.Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
-
Patent number: 8701658Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.Type: GrantFiled: August 14, 2012Date of Patent: April 22, 2014Assignee: Discovery Laboratories, Inc.Inventors: Jan Mazela, Christopher Henderson
-
Publication number: 20140088025Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. A method of making lyophilized pulmonary surfactants is described.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicant: DISCOVERY LABORATORIES, INC.Inventors: Sergio CESCO-CANCIAN, Thomas HOY, Edward H. TRAPPLER, Michael S. THOMAS
-
Publication number: 20140088026Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicant: DISCOVERY LABORATORIES, INC.Inventors: Sergio CESCO-CANCIAN, Thomas HOY, Edward H. TRAPPLER, Michael S. THOMAS
-
Publication number: 20130184198Abstract: Synthetic pulmonary surfactant compositions comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid are provided. Methods for treating respiratory disease are also provided comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid.Type: ApplicationFiled: November 29, 2012Publication date: July 18, 2013Applicant: DISCOVERY LABORATORIES, INC.Inventor: Discovery Laboratories, Inc.
-
Publication number: 20130146053Abstract: An adaptor for delivering an active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.Type: ApplicationFiled: November 5, 2012Publication date: June 13, 2013Applicant: Discovery Laboratories, Inc.Inventors: Jan Mazela, Christopher R. Henderson, Hope M. Miller
-
Publication number: 20130000641Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.Type: ApplicationFiled: August 14, 2012Publication date: January 3, 2013Applicant: DISCOVERY LABORATORIES, INC.Inventors: Jan MAZELA, Christopher HENDERSON
-
Patent number: 8337815Abstract: Synthetic pulmonary surfactant compositions comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid are provided. Methods for treating respiratory disease are also provided comprising administering a therapeutically effective amount of a synthetic pulmonary surfactant comprising dipalmitoyl phosphatidylcholine, phosphatidylglycerol, and essentially neutral lipid, and having essentially no 1-palmitoyl 2-oleoyl phosphatidylglycerol and essentially no palmitic acid.Type: GrantFiled: December 21, 2005Date of Patent: December 25, 2012Assignee: Discovery Laboratories, Inc.Inventors: Maithili Rairkar, Rom E Eliaz, Ralph Niven, Mark E. Johnson
-
Patent number: 8221772Abstract: Methods and compositions to enhance mucus clearance and to treat pulmonary lung disorders such as cystic fibrosis are disclosed. The methods utilize compositions including synthetic pulmonary surfactants having one or more phospholipids and a synthetic polypeptide, administered alone or combined with hyperosmotic agents, to patients in an amount effective to enhance mucus clearance.Type: GrantFiled: September 19, 2007Date of Patent: July 17, 2012Assignee: Discovery Laboratories Inc.Inventors: Mark. E. Johnson, Robert Segal, Thomas Hofmann, Robert J. Capetola
-
Publication number: 20110011395Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.Type: ApplicationFiled: March 17, 2009Publication date: January 20, 2011Applicant: DISCOVERY LABORATORIES, INC.Inventors: Jan Mazela, Christopher Henderson
-
Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
Patent number: 7582312Abstract: Methods of producing lung surfactant formulations through solvent dissolution and lyophilization are described as well as surfactant formulations derived therefrom. Methods of treating respiratory distress dysfunction are also provided.Type: GrantFiled: November 14, 2005Date of Patent: September 1, 2009Assignee: Discovery Laboratories, Inc.Inventors: Mark Johnson, Roy Coe -
Patent number: 7541331Abstract: Regimens for the therapeutic or prophylactic administration of pulmonary surfactant to infants exhibiting or at risk of developing bronchopulmonary dysplasia are disclosed.Type: GrantFiled: January 6, 2006Date of Patent: June 2, 2009Assignee: Discovery Laboratories, Inc.Inventors: Anthony Killian, Christopher Schaber, Robert Segal, Carlos Guardia
-
Patent number: 5962523Abstract: The present invention relates to methods of protecting against injury to hair follicles in a mammal by administering an effective amount of butyric acid or a biologically active butyric acid derivative. In particular, this invention relates to the use of cell differentiation-inducing butyric acid derivatives to protect against hair loss in cancer patients undergoing chemotherapy and/or radiation therapy.Type: GrantFiled: October 25, 1996Date of Patent: October 5, 1999Assignee: Discovery Laboratories, Inc.Inventors: S. Mark Moran, Thomas R. Alessi