Abstract: A system and method for measuring the greenhouse gas emitting activities of a user is described. Data for different sources of greenhouse gas emitting user activities, including electricity usage, motor vehicle usage, food consumption, and flight usage, are gathered, normalized, weighted, and presented. The system and method include providing the user with feedback regarding these activities and rewarding the user for changing these activities to thereby reduce their greenhouse gas emissions.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: A tracking device and method of determining a location of a tag connected to an object. The method comprises transmitting a first message from a server over a long range communication protocol to the tag so that the tag emits short and long range distress messages; receiving at a server the long range distress messages including location data using the long range communication protocol; using the location data to determine a geographical area in which the tag is located; transmitting a message from the server to one or more mobile devices in the geographic area to enable the mobile devices to receive the short range distress messages; receiving at the mobile devices the short range distress messages from the tag and using the received short range distress message to locate the tag; and transmitting a second message from the mobile devices to the server including the location of the tag.

Abstract: Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.

Abstract: The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: The present invention relates to receptor tyrosine kinase-like orphan receptor 1 (ROR1) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention relates to a cytochrome P450 enzyme comprising the amino acid sequence set forth in SEQ ID NO: 3, or a variant thereof having an amino acid sequence having at least 95% identity thereto and having CYP450 activity. The cytochrome P450 enzyme provided herein was isolated from Streptomyces eurythermus NRRL 2539 and has a wide substrate range and high activity, and may be used to oxidate organic compounds.

Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.

Abstract: A sensor tag which in use will be affixed to a vehicle for obtaining vehicle telematics data includes a battery for powering the tag and a processor running executable code to process accelerometer data. An accelerometer measures the acceleration of the tag and thereby of the vehicle, and also controls the operation of the processor. A memory is used for storing a unique tag identifier of the tag and for storing trip data including information about trips and acceleration data. Finally, a communication module is used for short range wireless communication with a mobile communications device located in the vehicle via a short range wireless communications protocol, the communication module transmitting the tag's unique identifier and a sequence of time stamped acceleration data. The mobile communications device obtains GPS data, combines this with the acceleration date and transmits this to a server for analysis.

Abstract: A system and method for measuring the greenhouse gas emitting activities of a user is described. Data for different sources of greenhouse gas emitting user activities, including electricity usage, motor vehicle usage, food consumption, and flight usage, are gathered, normalized, weighted, and presented. The system and method include providing the user with feedback regarding these activities and rewarding the user for changing these activities to thereby reduce their greenhouse gas emissions.

Abstract: A system for tracking objects includes tracking devices each attached to an object to be tracked and including a short range communications module. A server includes a processor and a memory. A mobile communications device (typically a mobile telephone) includes memory for storing an identification of the mobile device, a long range communication module for communication over a cellular communication network and a short range communications module for receiving short range signals transmitted from tracking devices. The mobile telephone also includes a location determination module to determine the location of the mobile telephone. On receipt of a short range distress signal from a tracking device, a location is obtained from the location module and a signal transmitted to the server including at least the identification of the tracking device, a time of receipt of the short range signal from the tracking device and the determined location of the tracking device when the short range signal was received.

Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: The present invention relates to bi-specific antigen binding molecules and associated fusion proteins and conjugates. In particular, the present invention relates to bi-specific antigen binding molecules with specificity for both receptor tyrosine kinase-like orphan receptor 1 (ROR1) and epidermal growth factor receptor (EGFR) and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: A sensor tag which in use will be affixed to a vehicle for obtaining vehicle telematics data includes a battery for powering the tag and a processor running executable code to process accelerometer data. An accelerometer measures the acceleration of the tag and thereby of the vehicle, and also controls the operation of the processor. A memory is used for storing a unique tag identifier of the tag and for storing trip data including information about trips and acceleration data. Finally, a communication module is used for short range wireless communication with a mobile communications device located in the vehicle via a short range wireless communications protocol, the communication module transmitting the tag's unique identifier and a sequence of time stamped acceleration data. The mobile communications device obtains GPS data, combines this with the acceleration date and transmits this to a server for analysis.

Abstract: The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Abstract: A tracking device and method of determining a location of a tag connected to an object. The method comprises transmitting a first message from a server over a long range communication protocol to the tag so that the tag emits short and long range distress messages; receiving at a server the long range distress messages including location data using the long range communication protocol; using the location data to determine a geographical area in which the tag is located; transmitting a message from the server to one or more mobile devices in the geographic area to enable the mobile devices to receive the short range distress messages; receiving at the mobile devices the short range distress messages from the tag and using the received short range distress message to locate the tag; and transmitting a second message from the mobile devices to the server including the location of the tag.

Abstract: The present disclosure is directed to pyrazolo[1,5-a]pyrimidine compounds of formula (I), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R21, R22, R23, R24 and R25 are as defined herein.

Abstract: A system for tracking objects includes tracking devices each attached to an object to be tracked and including a short range communications module. A server includes a processor and a memory. A mobile communications device (typically a mobile telephone) includes memory for storing an identification of the mobile device, a long range communication module for communication over a cellular communication network and a short range communications module for receiving short range signals transmitted from tracking devices. The mobile telephone also includes a location determination module to determine the location of the mobile telephone. On receipt of a short range distress signal from a tracking device, a location is obtained from the location module and a signal transmitted to the server including at least the identification of the tracking device, a time of receipt of the short range signal from the tracking device and the determined location of the tracking device when the short range signal was received.