Abstract: The present invention involves an improved process for the preparation of Indocyanine green of Formula (I) having high purity of about 99%, wherein the process comprises steps of reacting 1,1,2-trimethyl-1H-benzo[e]indole with 1,4-butane sulfone in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate. Followed by reacting 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula (IV) and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula (V) in presence of sodium acetate and alcohol; and extracting the title compound formula (I) with an ester solvent.
Type:
Grant
Filed:
November 29, 2016
Date of Patent:
May 14, 2019
Assignee:
DISHMAN CARBOGEN AMCIS LIMITED
Inventors:
Janmejay Rajnikant Vyas, Himani Dhotre, Narasimha Sarma, Babulal R. Patel, Dinesh Kumar Sharma, Dilip N. Patel, Ashish A. Soni