Patents Assigned to Divi's Laboratories Limited
  • Process for the preparation of advantame
    Patent number: 9512063
    Abstract: A novelprocess for the preparation of N—[N-[3-(3-hydroxy-4-methoxyphenyl)-propyl]-L-?-aspartyl]-L-phenylalanine-1-methyl ester is described. It comprises, reacting isovanillin or its derivative with vinyl acetate followed by reductive condensation with L-[?-aspartyl]-L-phenylalanine-1-methyl ester.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: December 6, 2016
    Assignee: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Process for the preparation of lacosamide
    Patent number: 9447024
    Abstract: A novel process for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide (Lacosamide) is described. It comprises reacting N-acetyl-D-serine methyl ester with benzylamine catalyzed by a non-nucleophilic base to obtain (R)-2-acetamido-2-N-benzyl-3-hydroxy propionamide followed by its methylation.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 20, 2016
    Assignee: Divi's Laboratories Limited
    Inventors: Satchandra Kiran Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF (1S, 3S, 5S)-2-[2(S)-2-AMINO-2-(3-HYDROXY-1-ADAMANTAN-1-YL ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE
    Publication number: 20130317235
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-242(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Application
    Filed: September 4, 2012
    Publication date: November 28, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE
    Publication number: 20130310573
    Abstract: Strontium ranelate is prepared by reacting dicyclohexylammonium ranelate with strontium halide in an anhydrous solvent. Strontium ranelate thus obtained will have less than 3% moisture content.
    Type: Application
    Filed: September 5, 2012
    Publication date: November 21, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF 4-IODO-3-NITROBENZAMIDE
    Publication number: 20130172618
    Abstract: A process for the preparation of 4-iodo-3-nitrobenzamide free from the impurities formed due to nucleophilic substitution of the labile iodo group is disclosed.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 4, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Venkataramana Rajuri
  • PROCESS FOR THE PREPARATION OF SUCRALOSE
    Publication number: 20130060018
    Abstract: The present invention provides a method for preparing colorless sucralose, wherein 4,1?,6?-trichloro-4,1?,6?-trideoxy-galacto sucrose-6- acetate containing colored impurities formed during chlorination of sucrose-6-acetate is treated with sodium hypochlorite, where sodium hypochlorite acts both as a decolorizing agent and as a reagent for the ester hydrolysis.
    Type: Application
    Filed: November 8, 2011
    Publication date: March 7, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030188
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030187
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20120330008
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a)
    Type: Application
    Filed: September 8, 2011
    Publication date: December 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • PREPARATION OF 2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID
    Publication number: 20120309973
    Abstract: Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 6, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Krishnaji Rao Mutyala
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE
    Publication number: 20120245379
    Abstract: Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.
    Type: Application
    Filed: June 7, 2011
    Publication date: September 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20120209006
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 16, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR ISOMERISATION OF LYCOPENE IN THE PRESENCE OF THIOUREA
    Publication number: 20120197055
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 2, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali
  • PROCESS FOR THE RESOLUTION OF (R,S)-NICOTINE
    Publication number: 20120197022
    Abstract: (R,S)-Nicotine was resolved through diastereomeric salt formation using dibenzoyl-d-tartaric acid and dibenzoyl-l-tartaric acid to obtain enantiomerically pure (S)-nicotine and (R)-nicotine.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 2, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR RESOLUTION OF 1-(3-HYDROXYPHENYL)-2-METHYLAMINO ETHANOL
    Publication number: 20120108848
    Abstract: Resolution of the title compound to its active isomer (R)-1-(3-hydroxyphenyl)-2-methylamino ethanol with (R)-naproxen as a resolving agent.
    Type: Application
    Filed: December 22, 2010
    Publication date: May 3, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Padakandla Gundu Rao, Bolneni Nageswara Rao, Medepudi Ramesh Babu, Mutyala Krishnaji Rao, Allupati Padmanav Patro
  • PROCESS FOR THE PREPARATION OF PREGABALIN
    Publication number: 20120041212
    Abstract: The present invention provides a new enantioselective method of preparing (S)-3-(aminomethyl)-5-methylhexanoic acid, commonly known as pregabalin. The invention also provides new chiral intermediates useful in the production of pregabalin.
    Type: Application
    Filed: January 3, 2011
    Publication date: February 16, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Srinivasan Subramanian Kuduva
  • PROCESS FOR THE PREPARATION OF GABAPENTIN
    Publication number: 20110306787
    Abstract: This invention discloses a process for converting gabapentin acid salt to free gabapentin, where the salt is dissolved in an organic solvent in which both gabapentin acid salt and free gabapentin are soluble. The solution is treated with a powdered alkaline base to liberate free gabapentin which will remain in solution. The insoluble alkali salt of the acid is removed by filtration. From the filtrate free gabapentin is obtained either by adding anti-solvent or by extraction with water.
    Type: Application
    Filed: December 14, 2010
    Publication date: December 15, 2011
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin, Maddipati Prasad
  • POLYMORPH OF STRONTIUM RANELATE AND A PROCESS FOR ITS PREPARATION
    Publication number: 20110275834
    Abstract: This invention discloses Strontium Ranelate polymorph, designated as Form A, having a characteristic powdered x-ray diffraction pattern and infrared spectrum with a water content of about 1.5 to 2.5% and a process for its preparation.
    Type: Application
    Filed: January 3, 2011
    Publication date: November 10, 2011
    Applicant: DIVI'S LABORATORIES, LIMITED
    Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • Polymorph of Quetiapine fumarate and a process for its preparation
    Patent number: 7488821
    Abstract: The present invention relates to a novel polymorph of Quetiapine fumarate and a simple method for its preparation.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: February 10, 2009
    Assignee: Divi's Laboratories Limited
    Inventors: Mysore Aswatha Rao, Srinivasan Subramanian Kuduva, Mellekatte Thimmesh Shreenivas
  • Process for the resolution of racemic (R,S) -5-(2-(2-(2- ethoxyphenoxy) ethylamino)Propyl)-2-methoxybenzene sulfonamide (tamsulosin), its novel R and S isomers and their salts and processes for their preparation
    Patent number: 7238839
    Abstract: An improved process is described to resolve a racemic mixture in any proportion of 5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy benzene sulfonamide as a free base or some of its salts, with BPA either S or R form to obtain enantiomerically highly pure R and S-isomer as a well characterized free base or as a salt of the title compound. Also described are novel R and S-isomers of 5-(2-(2-(2-ethoxyphenoxy) ethylamino)propyl)-2-methoxy benzene sulfonamide and their salts and the processes for their preparation.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: July 3, 2007
    Assignee: Divi's Laboratories Limited
    Inventors: Bolineni Nageswara Rao, Mutyala Krishnaji Rao, Allupati Padmanav Patro, Ambadipudi Udayalakshmi, Mutyala Veeraiah, Gundu Rao Padakandala