Patents Assigned to DNA Chip Research Inc.
  • Publication number: 20200385708
    Abstract: The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately.
    Type: Application
    Filed: January 27, 2020
    Publication date: December 10, 2020
    Applicants: DNA Chip Research Inc., Osaka Prefectural Hospital Organization
    Inventors: Kikuya KATO, Yoji Kukita, Ryo Matoba
  • Patent number: 10584331
    Abstract: The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 10, 2020
    Assignees: DNA Chip Research Inc., Osaka Prefectural Hospital Organization
    Inventors: Kikuya Kato, Yoji Kukita, Ryo Matoba
  • Publication number: 20150045244
    Abstract: The object of the invention is to find a simple biomarker with high reproducibility with regard to a method for evaluating the activity of the condition and progression of rheumatoid arthritis disease and provide an effective evaluation method therefor. The invention is to provide a method for determining the value of a rheumatoid arthritis-linked indicator in a subject, the method being characterized by comprising a step for measuring the amount of expression of the FAM20A gene in blood collected from the subject, a step for analyzing the measured amount of expression using a gene expression profile that is prepared in advance and correlates with the indicator and a step for estimating the value of the indicator in the subject on the basis of the analysis results.
    Type: Application
    Filed: November 17, 2011
    Publication date: February 12, 2015
    Applicants: DNA CHIP RESEARCH INC., SAITAMA MEDICAL UNIVERSITY, KEIO UNIVERSITY
    Inventors: Tsutomu Takeuchi, Koichi Amano, Yohei Ishizawa, Seiji Nakamura, Motohiko Tanino, Yuko Hata
  • Publication number: 20140227706
    Abstract: The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated.
    Type: Application
    Filed: May 16, 2012
    Publication date: August 14, 2014
    Applicants: DNA CHIP RESEARCH INC., Osaka Prefectural Hospital Organization
    Inventors: Kikuya Kato, Fumio Imamura, Kazuya Taniguchi, Toru Kumagai, Junji Uchida, Kazumi Nishino
  • Patent number: 8765417
    Abstract: Primers for DNA elongation are immobilized onto a substrate having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphoester composing the hydrophilic section of a phospholipid, and a second unit having an activated ester group, and DNA elongation reaction is allowed to proceed in a reaction system having introduced therein a sample which contains DNA fragments having desired sequences and nucleotide monomers, by heating the reaction system up to a temperature causing thermal unfolding of the DNA chains, and then by cooling the reaction system down to a temperature for annealing.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: July 1, 2014
    Assignees: Sumitomo Bakelite Co., Ltd., DNA Chip Research Inc.
    Inventor: Kenji Kinoshita
  • Patent number: 7491857
    Abstract: An aminated oligonucleotide probe is provided, in which the amino group possesses improved reactivity. The present invention relates to an oligonucleotide probe, which is represented by general formula 1: (wherein R1 is a hydrogen atom or a protecting group for an amino group, R2 and R3 are each independently a divalent organic group, and A is an oligonucleotide).
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: February 17, 2009
    Assignees: National Institute of Advanced Industrial Science and Technology, DNA Chip Research Inc.
    Inventors: Yasuo Komatsu, Naoshi Kojima, Kosuke Sato, Ken Nonaka, Yumi Fujinawa
  • Publication number: 20080227968
    Abstract: An aminated oligonucleotide probe is provided, in which the amino group possesses improved reactivity. The present invention relates to an oligonucleotide probe, which is represented by general formula 1: (wherein R1 is a hydrogen atom or a protecting group for an amino group, R2 and R3 are each independently a divalent organic group, and A is an oligonucleotide).
    Type: Application
    Filed: November 17, 2005
    Publication date: September 18, 2008
    Applicants: National Institute of Advanced Industrial Science and Technology, DNA Chip Research Inc.
    Inventors: Yasuo Komatsu, Naoshi Kojima, Kosuke Sato, Ken Nonaka, Yumi Fujinawa
  • Publication number: 20040091899
    Abstract: A coated substrate for immobilizing a biological substance etc. at high density with low background value. The substrate has a cross-linking reagent represented by general formula A—L—B (wherein, A and B represent an identical or different group which reacts with an active group of the coupling agent comprising an active group, selected from an active ester group, isothiocyanate group, isocyanate group, imidazole group, carbodiimide group or aldehyde group, and wherein L is a linking group linking A and B, selected from a straight chain alkyl group, aryl group, allyl group or alkyl group having an amide group) bound thereonto by means of a coupling agent comprising an active group. An biological substance or the like is immobilized on the substrate.
    Type: Application
    Filed: June 24, 2003
    Publication date: May 13, 2004
    Applicants: DNA Chip Research, Inc., Hitachi Software Engineering Co., Ltd.
    Inventors: Yasuo Komatsu, Kenichi Matsubara, Eiko Ohtsuka, Ken Nonaka, Noriko Yurino
  • Publication number: 20040058844
    Abstract: A solution for substrate spotting and spotting method for immobilizing a biological substance or various chemical substances on a substrate at high density. The solution for substrate spotting and the spotting method involve mixing a solution comprising a biological substance or chemical substance to be spotted with a solution to which an inorganic fine powder has been added as a surface tension regulating agent.
    Type: Application
    Filed: June 23, 2003
    Publication date: March 25, 2004
    Applicants: DNA Chip Research, Inc., Hitachi Software Engineering Co., Ltd.
    Inventors: Yasuo Komatsu, Kenichi Matsubara, Eiko Ohtsuka, Ken Nonaka, Noriko Yurino