Patents Assigned to DNA Electronics Ltd.
  • METHOD AND APPARATUS FOR MEASURING CHEMICAL ION CONCENTRATION USING A FEEDBACK- CONTROLLED TITRATOR
    Publication number: 20150024509
    Abstract: There is provided a method and device for measuring an ion concentration of a sample. The method comprises exposing a chemical sensor to the sample to provide an electrical output signal 5 representing said ion concentration and controlling a titrator exposed to the sample to release or absorb a quantity of ions to the sample. The method may use feedback means comprising Pulse Width Modulation control to drive the titrator such that the sample maintains a stable ion concentration.
    Type: Application
    Filed: March 6, 2012
    Publication date: January 22, 2015
    Applicant: DNA ELECTRONICS LTD.
    Inventors: Christofer Toumazou, Yan Liu
  • NUCLEIC ACID AMPLIFICATION
    Publication number: 20140170661
    Abstract: A method of monitoring amplification of a nucleic acid by providing a nucleic acid and an amplification mixture using the kit of isothermal reagents to a pH sensor or pH indicator, amplifying the nucleic acid using isothermal amplification, and detecting a change in pH due to the amplification using the pH sensor or pH indicator. The kit of reagents comprises a magnesium salt, a quaternary ammonium salt, and an alkali base.
    Type: Application
    Filed: July 16, 2012
    Publication date: June 19, 2014
    Applicant: DNA ELECTRONICS LTD
    Inventors: Maurizio Lamura, Angel Chan-Ju Wang, Alpesh Patel
  • Sensing apparatus and method
    Patent number: 8698211
    Abstract: A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: April 15, 2014
    Assignee: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Sunil Purushothaman
  • SENSING APPARATUS AND METHOD
    Publication number: 20120175252
    Abstract: A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 12, 2012
    Applicant: DNA ELECTRONICS LTD.
    Inventors: Christofer TOUMAZOU, Sunil Purushothaman
  • Sensing apparatus and method
    Patent number: 8114591
    Abstract: A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: February 14, 2012
    Assignee: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Sunil Purushothaman
  • qPCR using solid-state sensing
    Patent number: 7888015
    Abstract: Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: February 15, 2011
    Assignee: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Sunil Purushothaman
  • Sensing Apparatus and Method
    Publication number: 20100255595
    Abstract: A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
    Type: Application
    Filed: January 23, 2007
    Publication date: October 7, 2010
    Applicant: DNA ELECTRONICS LTD.
    Inventors: Christofer Toumazou, Sunil Purushothaman
  • Ion sensitive field effect transistors
    Publication number: 20100159461
    Abstract: According to a first aspect of the present invention there is provided a digital signal processing circuit, one or more switches of the circuit being provided by an ion sensitive field effect transistor.
    Type: Application
    Filed: December 2, 2009
    Publication date: June 24, 2010
    Applicant: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Bhusana Premanode, Leila Shepherd
  • Signal processing circuit comprising ion sensitive field effect transistor and method of monitoring a property of a fluid
    Patent number: 7649358
    Abstract: A signal processing circuit includes an ion sensitive field effect transistor, a reference electrode for the ion sensitive field effect transistor, a metal oxide semiconductor transistor having its gate coupled to the reference electrode, and a biasing circuit. The biasing circuit is configured to bias the ion sensitive field effect transistor and the metal oxide semiconductor field effect transistor to operate in a weak inversion region and to provide an output current signal.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: January 19, 2010
    Assignee: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Bhusana Premanode, Leila Shepherd
  • Signal Processing Circuit Comprising Ion Sensitive Field Effect Transistor and Method of Monitoring a Property of a Fluid
    Publication number: 20080265985
    Abstract: A signal processing circuit comprising one or more ion sensitive field effect transistors, ISFETs, and a biasing circuit for biasing the or each ion sensitive field effect transistor to operate in the weak inversion region.
    Type: Application
    Filed: June 22, 2005
    Publication date: October 30, 2008
    Applicant: DNA ELECTRONICS LTD.
    Inventors: Christofer Toumazou, Bhusana Premanode, Leila Shepherd
  • Sensing apparatus and method
    Publication number: 20080032295
    Abstract: Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.
    Type: Application
    Filed: March 2, 2007
    Publication date: February 7, 2008
    Applicant: DNA Electronics Ltd.
    Inventors: Christofer Toumazou, Sunil Purushothaman