Patents Assigned to DNA-SEQ, Inc.
  • Methods and systems for determination of an effective therapeutic regimen and drug discovery
    Patent number: 11230741
    Abstract: The present invention relates to the discovery of a method for identifying a treatment regimen for a patient diagnosed with cancer, predicting patient resistance to therapeutic agents and identifying new therapeutic agents. Specifically, the present invention relates to the use of an algorithm to identify a mutation in a kinase, determine if the mutation is an activation or resistance mutation and then to suggest an appropriate therapeutic regimen. The invention also relates to the use of a pattern matching algorithm and a crystal structure library to predict the functionality of a gene mutation, predict the specificity of small molecule kinase inhibitors and for the identification of new therapeutic agents.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: January 25, 2022
    Assignee: DNA-SEQ, Inc.
    Inventor: Janusz Sowadski
  • Methods and systems for determination of an effective therapeutic regimen and drug discovery
    Patent number: 10392669
    Abstract: The present invention relates to the discovery of a method for identifying a treatment regimen for a patient diagnosed with cancer, predicting patient resistance to therapeutic agents and identifying new therapeutic agents. Specifically, the present invention relates to the use of an algorithm to identify a mutation in a kinase, determine if the mutation is an activation or resistance mutation and then to suggest an appropriate therapeutic regimen. The invention also relates to the use of a pattern matching algorithm and a crystal structure library to predict the functionality of a gene mutation, predict the specificity of small molecule kinase inhibitors and for the identification of new therapeutic agents.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: August 27, 2019
    Assignee: DNA-SEQ, Inc.
    Inventor: Janusz Sowadski
  • Methods and systems for determination of an effective therapeutic regimen and drug discovery
    Patent number: 10093982
    Abstract: The present invention relates to the discovery of a method for identifying a treatment regimen for a patient diagnosed with cancer, predicting patient resistance to therapeutic agents and identifying new therapeutic agents. Specifically, the present invention relates to the use of an algorithm to identify a mutation in a kinase, determine if the mutation is an activation or resistance mutation and then to suggest an appropriate therapeutic regimen. The invention also relates to the use of a pattern matching algorithm and a crystal structure library to predict the functionality of a gene mutation, predict the specificity of small molecule kinase inhibitors and for the identification of new therapeutic agents.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: October 9, 2018
    Assignee: DNA-SEQ, Inc.
    Inventors: Janusz Sowadski, Davide Moiani