Abstract: The present invention relates to a spray-dried composition comprising as an active ingredient at least one member protein of the collectin family or its functional equivalent for treating and preventing microbial infectious diseases. The present invention also relates to a method for producing the same composition. The composition produced by the method of the present invention is effective in suppressing infections caused by viruses, bacteria, fungi, and parasites. Since the composition is developed in a form suitable for inhalation, it can directly provide the active ingredient to the sites of infection from these microbes, and thus treat and prevent respiratory infections and external wounds.
Type:
Application
Filed:
April 18, 2012
Publication date:
August 9, 2012
Applicant:
DOBEEL CORPORATION
Inventors:
Hong Mo MOON, Jung Sun YUM, Byung Cheol AHN, Joo Youn LEE
Abstract: The present invention relates to an adjuvant comprising a lipopeptide and poly I:C. When the adjuvant of the present invention is used, the level of antigen specific antibody induction is synergistically increased and Th1 type immune response is also induced. Therefore, the adjuvant of the present invention can be very effectively used as an adjuvant in the formulation of preventive and therapeutic vaccines for viral or parasitic infection and cancer.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
July 10, 2012
Assignee:
Dobeel Corporation
Inventors:
Hong Mo Moon, Byung Cheol Ahn, Jung-Sun Yum
Abstract: The present invention relates to an HBV vaccine comprising an entire hepatitis B surface antigen of L protein, M protein and S protein, in which the produced antigens form virus-like particles, and a multi-antigen vaccine further comprising an HBV core antigen in addition to the entire surface antigen, and a method for preparing the same. The vaccines provide various epitopes and have excellent immunogenicity to induce a strong humoral immune response as well as a cell-mediated immune response.
Type:
Grant
Filed:
January 28, 2008
Date of Patent:
July 10, 2012
Assignee:
Dobeel Corporation
Inventors:
Jung Sun Yum, Byung Cheol Ahn, Hyun Jin Jo, Dong Yeon Kim, Joo Youn Lee, Ki Hyun Kim, Jae Seung Yoon, Hong Mo Moon
Abstract: The present invention relates to a spray-dried composition comprising as an active ingredient at least one member protein of the collectin family or its functional equivalent for treating and preventing microbial infectious diseases. The present invention also relates to a method for producing the same composition. The composition produced by the method of the present invention is effective in suppressing infections caused by viruses, bacteria, fungi, and parasites. Since the composition is developed in a form suitable for inhalation, it can directly provide the active ingredient to the sites of infection from these microbes, and thus treat and prevent respiratory infections and external wounds.
Type:
Grant
Filed:
May 18, 2006
Date of Patent:
May 8, 2012
Assignee:
Dobeel Corporation
Inventors:
Hong Mo Moon, Jung Sun Yum, Byung Cheol Ahn, Joo Youn Lee
Abstract: The present invention relates to an adjuvant comprising a lipopeptide and poly I:C. When the adjuvant of the present invention is used, the level of antigen specific antibody induction is synergistically increased and Th1 type immune response is also induced. Therefore, the adjuvant of the present invention can be very effectively used as an adjuvant in the formulation of preventive and therapeutic vaccines for viral or parasitic infection and cancer.
Type:
Application
Filed:
December 5, 2008
Publication date:
June 18, 2009
Applicant:
DOBEEL CORPORATION
Inventors:
Hong Mo Moon, Byung Cheol Ahn, Jung-Sun Yum
Abstract: The present invention relates to a spray-dried composition comprising as an active ingredient at least one member protein of the collectin family or its functional equivalent for treating and preventing microbial infectious diseases. The present invention also relates to a method for producing the same composition. The composition produced by the method of the present invention is effective in suppressing infections caused by viruses, bacteria, fungi, and parasites. Since the composition is developed in a form suitable for inhalation, it can directly provide the active ingredient to the sites of infection from these microbes, and thus treat and prevent respiratory infections and external wounds.
Type:
Application
Filed:
May 18, 2006
Publication date:
July 5, 2007
Applicant:
Dobeel Corporation
Inventors:
Hong Moon, Jung Yum, Byung Ahn, Joo Lee
Abstract: This invention comprises of construction of a recombinant CHO cell line that produces functional mannose binding lectin (MBL) and of special uses of MBL. Specially, use of MBL for development of a therapeutic agent for patients having systemic infection with viruses, bacteria, or fungus is described. More specifically, MBL as a trigger for complement activation and MBL so formulated to activate complement system for the purpose of treating patients with microbial infection.
Type:
Grant
Filed:
August 15, 2003
Date of Patent:
November 14, 2006
Assignee:
Dobeel Corporation
Inventors:
Hong Mo Moon, Jung-Sun Yum, Byung Cheol Ahn