Patents Assigned to Dominion Pharmakine S.L.
  • Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
    Patent number: 8097656
    Abstract: This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: January 17, 2012
    Assignees: Dominion Pharmakine S.L, Universidad del Pais Vasco
    Inventors: Fernando Pedro Cossio, Eneko Aldaba Arevalo, Yosu Ion Vara Salazar, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, Clarisa Salado Pogonza, Natalia Gallot Escobal, Fernando Vidal Vanaclocha
  • Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof
    Patent number: 7943660
    Abstract: The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: May 17, 2011
    Assignee: Dominion Pharmakine S.L.
    Inventors: Natalia Gallot Escobal, Fernando Vidal Vanaclocha, Fernando Pedro Cossio Mora, Miren Lorea Mendoza Arteche, Aizpea Zubia Olascoaga, Maria Valcarcel Cuesta, Yosu Ion Vara Salazar, Miren Sorne Solaun Aguirre, Jose Javier Lopez Pestana, Eider San Sebastian Larzabal
  • NITROGENATED TRANS-STILBENE ANALOGS, METHOD FOR THE OBTENTION AND MEDICAL APPLICATIONS THEREOF
    Publication number: 20110060038
    Abstract: This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.
    Type: Application
    Filed: August 23, 2010
    Publication date: March 10, 2011
    Applicants: DOMINION PHARMAKINE S.L., UNIVERSIDAD DEL PAIS VASCO
    Inventors: Fernando Pedro Cossio, Eneko Aldaba Arevalo, Yosu Ion Vara Salazar, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, Clarisa Salado Pogonza, Natalia Gallot Escobal, Fernando Vidal Vanaclocha
  • Derivatives of nitroproline compounds, processes of manufacture and uses in the treatment of integrin mediated disorders
    Patent number: 7446125
    Abstract: This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also relates to the administration of compounds of the invention as agents for the treatment of mammalian diseases whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable cellular and molecular activities or responses induced by integrin-dependent molecular interactions.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: November 4, 2008
    Assignees: Universidad del Pais Vasco, Dominion Pharmakine S.L.
    Inventors: Fernando Pedro Cossio, Eneko Aldaba Arévalo, Yosu Ion Vara Salazr, Aizpea Zubia Olascoaga, Silvia Vivanco Amato, Miren Lorea Mendoza Arteche, María Valcárcel Cuesta, Fernando Vidal Vanaclocha
  • Novel Inhibitors of the Lfa-1/Icam-1 Interaction and Uses Thereof
    Publication number: 20080249157
    Abstract: The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: November 14, 2005
    Publication date: October 9, 2008
    Applicants: DOMINION PHARMAKINE S.L., UNIVERSIDAD DEL PAIS VASCO
    Inventors: Fernando Pedro Cossio Mora, Eider San Sebastian Larzabal, Miren Lorea Mendoza Arteche, Aizpea Zubia Olascoaga, Maria Valcarcel Cuesta, Yosu Ion Vara Salazar, Miren Sorne Solaun Aguirre, Jose Javier Lopez Pestana, Natalia Gallot Escobal, Fernando Vidal Vanaclocha