Patents Assigned to DOMPÉ FARMACEUTICI S.P.A.
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Patent number: 12268671Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of chemotherapy-induced neuropathy, preferably in the treatment and/or prevention of chemotherapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.Type: GrantFiled: January 13, 2017Date of Patent: April 8, 2025Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Laura Brandolini, Pier Adelchi Ruffini, Marcello Allegretti
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Patent number: 12186359Abstract: The present invention relates to compositions comprising branched-chain amino acids (BCAA) and the dipeptide L-Alanyl-L-alanine and their use for improving the performance and recovery during physical activity and for the prevention and/or treatment of muscle wasting associated to pathological or age-related conditions.Type: GrantFiled: June 29, 2020Date of Patent: January 7, 2025Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
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Patent number: 12150933Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of interstitial cystitis/painful bladder syndrome (IC/PBS) and/or over active bladder (OAB), also including IC/PBS and/or OAB induced by anticancer therapy. Methods of treatment and/or prevention, combinations and kits comprising said IL-8 inhibitors are also covered therein.Type: GrantFiled: July 12, 2016Date of Patent: November 26, 2024Assignee: DOMPÈ FARMACEUTICI S.P.A.Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta, Gianluca Bianchini, Laura Brandolini, Patrizia Angelico
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Patent number: 12133843Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of secondary bacterial infections, preferably secondary respiratory infections.Type: GrantFiled: May 28, 2018Date of Patent: November 5, 2024Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Laura Brandolini, Marcello Allegretti, Mauro Martins Teixeira
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Patent number: 12102607Abstract: The present invention relates to C5aR inhibitor compounds, preferably C5aR noncompetitive allosteric inhibitors, useful in the treatment and/or prevention of chemotherapy-induced iatrogenic pain (CIIP).Type: GrantFiled: December 11, 2018Date of Patent: October 1, 2024Assignee: Dompe' Farmaceutici S.P.A.Inventors: Laura Brandolini, Thiago Mattar Cunha, Marcello Allegretti, Andrea Aramini, Gianluca Bianchini
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Patent number: 12097172Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.Type: GrantFiled: February 24, 2022Date of Patent: September 24, 2024Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.Inventors: Paolo Fiorina, Roberto Bassi, Andrea Vergani, Marcello Allegretti
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Patent number: 11969501Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.Type: GrantFiled: August 18, 2021Date of Patent: April 30, 2024Assignees: DOMPÉ FARMACEUTICI S.P.A., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Michael Christopher Scaife, Benedikt Vollrath, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Patent number: 11918653Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: GrantFiled: December 21, 2018Date of Patent: March 5, 2024Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi, Martha Pastuszka
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Patent number: 11660291Abstract: The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of some sarcomas, preferably in the treatment and/or prevention of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma or lung metastasis associated thereof.Type: GrantFiled: October 23, 2018Date of Patent: May 30, 2023Assignees: Dompe' Farmaceutici S.P.A., Research Institute at Nationwide Children's HospitalInventors: Ryan David Roberts, Laura Brandolini
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Publication number: 20220184009Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.Type: ApplicationFiled: February 24, 2022Publication date: June 16, 2022Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.Inventors: Paolo FIORINA, Roberto BASSI, Andrea VERGANI, Marcello ALLEGRETTI
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Patent number: 11324630Abstract: A medical device (100) for the instillation of medical products in droplet form is described, said device comprising a hollow cylindrical body (10) and a rod (20) slidably mobile inside the hollow cylindrical body (10) and provided with a head (21) on which a rubber washer (40) is fixed, which washer, during the sliding of the rod (20), is in contact with an inner surface of the hollow cylindrical body (10). The rod (20) is formed as two portions (22, 24) of different diameter and the device (100) further comprises a sealing bush (30) between the hollow cylindrical body (10) and the rod (20), wherein there is provided a stop (32) which prevents the passage of the portion (22) with a larger circular section of the rod (20).Type: GrantFiled: June 29, 2017Date of Patent: May 10, 2022Assignee: DOMPE' FARMACEUTICI S.P.A.Inventor: Alfredo Ricci
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Patent number: 11291641Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.Type: GrantFiled: October 3, 2017Date of Patent: April 5, 2022Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.Inventors: Paolo Fiorina, Roberto Bassi, Andrea Vergani, Marcello Allegretti
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Patent number: 11236129Abstract: The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.Type: GrantFiled: January 26, 2021Date of Patent: February 1, 2022Assignee: Dompe' Farmaceutici S.P.A.Inventors: Marcello Allegretti, Andrea Aramini, Andrea Beccari, Marica Gemei, Flavio Mantelli
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Patent number: 11103379Abstract: The present invention relates to a device (1) for dispensing eye drops comprising a first container (2) containing water for injection (200) and a second container (3) containing a freeze-dried composition (300) comprising a drug. The first container (2) comprises a tubular element (9) with an open end portion (10) and the second container (3) comprises a wall (16) configured to be engaged in a fluid-tight manner around the tubular element (9) and a piercible barrier (17) which, in the assembled condition of the device (1), prevents mixing of the substances contained inside the first and second containers (2, 3). The drop dispensing device (1) also comprises a spacer (4) arranged between the first and second containers (2, 3); the spacer (4) does not allow the tubular element (9) to pierce the piercible barrier (17).Type: GrantFiled: April 7, 2016Date of Patent: August 31, 2021Assignee: DOMPE' FARMACEUTICI S.P.A.Inventor: Marco Maria Gentile
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Patent number: 11046662Abstract: The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). The compounds of the invention are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.Type: GrantFiled: December 6, 2018Date of Patent: June 29, 2021Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Andrea Aramini, Gianluca Bianchini, Laura Brandolini, Andrea Beccari, Samuele Lillini, Giuseppe Nano
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Patent number: 10508090Abstract: The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.Type: GrantFiled: August 7, 2017Date of Patent: December 17, 2019Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Maria De Pizzol, Anna Sirico, Mara Zippoli, Gianluca Bianchini, Andrea Beccari, Andrea Aramini, Chiara Rossana Maria Liberati
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Patent number: 10442583Abstract: A process for the production of a device for dispensing eye drops. The process includes the steps of providing a first container and a second container configured to be engaged in a fluid-tight manner, providing a spacer, introducing a water-based solution inside the first container, introducing a solution or dispersion comprising a drug inside the second container, arranging the spacer between the first and second containers, engaging in a fluid-tight manner the second container and the first container, and freeze-drying the solution or dispersion comprising the drug.Type: GrantFiled: April 7, 2016Date of Patent: October 15, 2019Assignee: DOMPE' FARMACEUTICI S.P.A.Inventor: Marco Maria Gentile
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Publication number: 20190224148Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.Type: ApplicationFiled: October 3, 2017Publication date: July 25, 2019Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, DOMPE FARMACEUTICI S.P.A.Inventors: Paolo FIORINA, Roberto BASSI, Andrea VERGANI, Marcello ALLEGRETTI
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Patent number: 10246448Abstract: The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I): Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold-induced and/or exacerbated-respiratory disorders, urological disorders, corneal disorders associated to disturbances in the production of the tears and/or altered blinking such as epiphora and dry eye disease.Type: GrantFiled: December 16, 2016Date of Patent: April 2, 2019Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Andrea Aramini, Gianluca Bianchini, Samuele Lillini
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Patent number: 10196368Abstract: The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.Type: GrantFiled: June 23, 2015Date of Patent: February 5, 2019Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Andrea Aramini, Gianluca Bianchini, Laura Brandolini, Andrea Beccari, Samuele Lillini, Giuseppe Nano