Abstract: Compounds of formula I: ##STR1## wherein R.sub.a, R.sub.b, .PHI., B and R are as defined in the disclosure, have antagonistic activity on osteoclast hyper-reactivity.

Abstract: A pharmaceutical composition for parenteral administration having anti-inflammatory and analgesic properties is disclosed which contain, as the active principle, alkylammonium salts of 2-arylpropionic acids.

Abstract: The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.

Abstract: The salts of S(+) 2-(3-benzoylphenyl)propionic acid and of R(-) 2-(3-benzoylphenyl)propionic acid with an organic base such as D-lysine, L-lysine, L-arginine, (R) 3-(4-phenylpiperazin-1-yl)propane-1,2-diol and (S) 3-(4-phenylpiperazin-1-yl)propane-1,2-diol, the process for their preparation and the corresponding pharmaceutical compositions containing said salts are described.

Abstract: Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C.sub.2 -C.sub.12 acyl group, R is phenyl and n is 0-12.

Abstract: Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C.sub.2 -C.sub.12 acyl group, R is phenyl and n is 0-12.

Abstract: A hydrophile pharmaceutical composition in the form of foam is described which contains as active ingredient Ketoprofen lysine salt having a concentration between 10 and 20% p/volume of solution which allows, for topic treatment, the maximum absorption of the active principle. The foam is applied for the local treatment in painful and phlogistic conditions, of rheumatic or traumatic nature, of the articulations, of the musles, of the tendons and of the ligaments.

Abstract: A hydrophile pharmaceutical composition in the form of foam is described which contains as active ingredient Ketoprofen lysine salt having a concentration between 10 and 20% p/volume of solution which allows, for topic treatment, the maximum absorption of the active principle.The foam is applied for the local treatment in painful and phlogistic conditions, of rheumatic or traumatic nature, of the articulations, of the musles, of the tendons and of the ligaments.

Abstract: Derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane, the process for their preparation as well as the pharmaceutical compositions containing them as active ingredients are described. The compounds exhibit anti-allergic activity.

Abstract: A process for the optical resolution of racemic dropropizine, carried out using L(+)tartaric acid as the optical resolution agent in aqueous medium, is described.

Abstract: Novel 2-piperidinylimidazopyridines of the formula: ##STR1## wherein R represents an alkoxyalkyl radical containing 4 to 6 carbon atoms; an optionally substituted benzyl radical or a tetrahydrofurfuryl radicalas well as the non-toxic, pharmaceutically acceptable acid addition salts thereof.The compounds of formula I are endowed with an interesting antihistaminic and antiallergic activity.

Abstract: Novel imidazopyridine derivatives of formula: ##STR1## wherein, R represents an alkoxyalky radical having 4-6 carbon atoms or a benzyl radical optionally substituted by a halogen atom, an alkyl or alkoxy radical having up to 3 carbon atoms,X represents hydrogen or an alkyl radical having up to 3 carbon atoms,n represents 0 or 1m represents an integer of from 2 to 5 inclusive,R.sub.1 and R.sub.2 may be the same or different and represent a saturated or unsaturated alkyl radical containing up to 4 carbon atoms or they, taken together with the adjacent nitrogen atom, may form a pyrrolidine, piperazine or homopiperazine ring which may be optionally substituted by an alkyl radical containing up to 3 carbon atoms, provided that when n is zero also m is zero and --N(R.sub.1)R.sub.2 represents the above defined piperazine or homopiperazine ring.The compounds (I) have an antihistaminic activity.

Abstract: 2-substituted 3-(2-ethoxyethyl)imidazo[4,5-b] pyridine derivatives of the formula ##STR1## wherein n is an integer of from 1 to 5 inclusiveR.sub.1 and R.sub.2 represent each a saturated or unsaturated alkyl radical containing from 1 to 4 carbon atoms or they form, together with the adjacent nitrogen atom an optionally substituted heterocyclic ring andthe corresponding non-toxic pharmaceutically acceptable acid addition salts.The compounds of formula (I) are endowed with antiallergic and antihistaminic activity.

Abstract: New alkylthiobenzimidazole derivatives are described which belong to the class of formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a 1-3 carbon atom alkyl radical or they may form with the adjacent nitrogen atom, an optionally substituted heterocyclic ring,X represents a hydrogen atom or methyl radicaln is 1 or 2R.sub.3 represents a 4-6 carbon atom alkoxyalkyl radical, a 7 or 8 carbon atom arylalkyl radical or a 5 or 6 carbon atom cycloalkyl radical with the exception that R.sub.3 may not be an arylalkyl radical when R.sub.1 and R.sub.2 each represent a 1-3 carbon atom alkyl radicalR.sub.4 and R.sub.5 may be the same or different and each represent a hydrogen atom or a 1-2 carbon atom alkyl or they, attached at the positions 5 and 6 of the benzimidazole nucleus, may form together the ring ##STR2## The compounds (I) possess interesting antihistaminic and anti-allergic activities.

Abstract: Novel benzimidazole derivatives (I) are described, of formula ##STR1## wherein A represents ##STR2## n is 0 or 1; m represents 0 or an integer of from 1 to 5 inclusive, provided that when n is 0, m represents an integer of from 2 to 5 inclusive;X represents a radical selected from the group consisting of benzyl, fluorobenzyl, alkoxyalkyl and tetrahydrofurfuryl;R.sub.1 and R.sub.2 represent each a saturated or unsaturated alkyl radical having of from 1 to 4 carbon atoms or they may form, together with the adjacent nitrogen atom, an optionally substituted heterocyclic ring selected from the group consisting of pyrrolidine and piperidine, and the corresponding, non-toxic, pharmaceutically acceptable acid addition salts.The compounds (I) are endowed with an interesting antihistaminic activity.

Abstract: New alkylol derivatives are described, which belong to the class having the structure formula ##STR1## where R represents a 5 or 6 membered heterocyclic ring selected among pyridine, pyrimidine, pyrazine, pyridazine, thiophene, furan, thiazole which optionally may be substituted with one or more groups selected among alkyl, alkoxy, halogen, amide, hydroxy, methylthio, trifluoromethyl, cyano, carboxy and the corresponding alkyl esters and salts with alkali metalsn is 2X and X' represent each a hydrogen atom or hydroxy group with the exception of both being hydrogen atom, and X' may be hydroxyethoxy moietym is 0 or 1and the corresponding non-toxic pharmaceutically acceptable acid addition salts. The compounds of the formula I are endowed with an interesting antitussive activity and, at their active dose, practically they are free of undesired side effects.

Abstract: The present invention refers to an improved method for the preparation of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one in which the condensation between 2-chloronicotinic acid and o-phenylenediamine is carried out by refluxing in the presence of a solvent consisting of a cycloalkanol. The end product is in pure state and it may be utilized as such.

Abstract: The optical isomers of 3-(4-phenyl-1-piperazinyl)-1,2-propanediol, a process for the stereo-selective preparation and pharmaceutical composition containing the same as active principles are described.

Abstract: The optical isomers of 3-(4-phenyl-1-piperazinyl)-1,2-propanediol, a process for the stereo-selective preparation and pharmaceutical composition containing the same as active principles are described.

Abstract: Compounds of the formula I ##STR1## wherein the A ring represents ##STR2## R.sub.1 and R.sub.2 are H or CH.sub.3 ; M is a cyclic amino group, are endowed with antiulcer, antisecretory, antimuscarinic and spasmolytic activity.