Abstract: The compounds of formula 1, wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.
Type:
Grant
Filed:
June 13, 2003
Date of Patent:
April 19, 2005
Assignee:
Dompé S.p.A.
Inventors:
Riccardo Bertini, Cinzia Bizzarri, Vilma Sabbatini, Gianfranco Caselli, Marcello Allegretti, Maria Candida Cesta, Carmelo Gandolfi, Marco Mantovanini, Francesco Colotta, Stefano Porzio
Abstract: (R)-2-Arylpropionamide compounds of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear leukocytes (leukocytes PMN) and of monocytes at the inflammatory sites. In particular, the invention relates to the R enantiomers of omega-aminoalkylamides of 2-aryl propionic acids, of formula (I), for use in the inhibition of the chemotaxis of neutrophils and monocytes induced by the C5a fraction of the complement and by other chemotactic proteins whose biological activity is associated with activation of a 7-TD receptor. Selected compounds of formula (I) are dual inhibitors of both the C5a-induced chemotaxis of neutrophils and monocytes and the IL-8-induced chemotaxis of PMN leukocytes.
Type:
Application
Filed:
February 25, 2002
Publication date:
April 14, 2005
Applicant:
Dompe S.p A.
Inventors:
Marcello Allegretti, Riccardo Bertini, Valerio Berdini, Cinzia Bizzarri, Maria Cesta, Vito Di Cioccio, Gianfranco Caselli, Francesco Colotta
Abstract: (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals useful as antitussive agents and as intermediates for the preparation of levodropropizine and the salts thereof, as well as a process for the preparation of said acetals, are disclosed.
Type:
Grant
Filed:
May 12, 2003
Date of Patent:
December 28, 2004
Assignee:
Dompé S.p.A.
Inventors:
Marcello Allegretti, Maria Candida Cesta, Roberto Curti, Luigi Pellegrini, Gabriella Melillo
Abstract: A process for the preparation of meta or para-substituted &agr;-arylalkanoic acids of formula (I)
wherein R and R1 are as defined in the disclosure.
Type:
Grant
Filed:
May 8, 2002
Date of Patent:
August 3, 2004
Assignee:
Dompe′ S.p.A
Inventors:
Marcello Allegretti, Maria Candida Cesta, Marco Mantovanini, Luca Nicolini
Abstract: Recombinant proteins derived by recombination of structural domains obtained from alpha and beta subunits of HGF and/or MSP growth factors. These recombinant proteins contain domains selected from HGF and MSP, and are useful to protect cells, including differentiated cell elements of liver, kidney, and mucosa of the gastorenteral tract, from death (i.e., apoptosis) induced by chemotherapeutics.
Type:
Grant
Filed:
September 8, 2000
Date of Patent:
May 4, 2004
Assignee:
Dompe' S.p.A.
Inventors:
Enzo Medico, Paolo Michieli, Chiara Colessi, Gianfranco Caselli, Paolo Comoglio
Abstract: Recombinant proteins deriving from recombination of structural domains deriving from the &agr; subunits of HGF and/or MSP growth factors. The recombinant proteins of the present invention have biological activity, and protect cells from death (apoptosis) induced by chemotherapeutic drugs. These molecules can conveninently be used to prevent or to treat the toxic side effects of chemotherapeutic agents used in cancer therapy.
Type:
Grant
Filed:
September 15, 2000
Date of Patent:
April 22, 2003
Assignee:
Dompe' S.p.A.
Inventors:
Enzo Medico, Paolo Michieli, Chiara Collesi, Gianfranco Caselli, Paolo Comoglio
Abstract: The present invention refers to the use of Macrophage Stimulating Protein (MSP) for the preparation of a medicament for the treatment of pathologies of the central and peripheral nervous system of traumatic, infectious or inflammatory origin.
Type:
Grant
Filed:
May 26, 1998
Date of Patent:
February 29, 2000
Assignee:
Dompe S.p.A.
Inventors:
Paolo Comoglio, Alessandro Vercelli, Francesco Galimi, Gianfranco Caselli, Maria Cristina Stella
Abstract: Hepatocyte growth factor stimulates proliferation and differentiation of hematopoietic cells, most preferably burst-forming unit-erythroid cells. The hepatocyte growth factor may be obtained from cells transformed with human gene sequences coding therefor. Pharmaceutical compositions useful to induce the proliferation and differentiation of hematopoietic cells may contain hepatocyte growth factor as an active principle in admixture with a suitable carrier. The pharmaceutical compositions may additionally contain stem cell factor as an active principle.
Abstract: DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells transformed with the said vectors containing the DNA coding for improved IL-1 antagonists and a method for the production of improved IL-1 antagonists in essentially pure form are also described. Preparations that can be injected or can be administered by some other route, consisting of a pharmaceutical preparation of the said mutants, are particularly useful as drugs in the field of therapy.
Type:
Grant
Filed:
April 15, 1997
Date of Patent:
July 13, 1999
Assignee:
Dompe' S.p.A.
Inventors:
Diana Boraschi, Paola Bossu, Paolo Ruggiero, Giovanni Macchia, Aldo Tagliabue, Francesco Frigerio, Renata Grifantini, Gianni Frascotti, Guido Grandi
Abstract: Compounds of formula I: ##STR1## wherein R.sub.a, R.sub.b, .PHI., B and R are as defined in the disclosure, have antagonistic activity on osteoclast hyper-reactivity.
Type:
Grant
Filed:
February 26, 1997
Date of Patent:
June 1, 1999
Assignee:
Dompe' S.p.A.
Inventors:
Marcello Allegretti, Marco Mantovanini, Gianfranco Caselli, Simonetta Fiorentino, Gaetano Clavenna, Carmelo A. Gandolfi
Abstract: The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.
Type:
Grant
Filed:
March 18, 1996
Date of Patent:
January 12, 1999
Assignee:
Dompe' S.p.A.
Inventors:
Luigi Boltri, Antonietta Coppola, Marco Gentile, Gaetano Clavenna