Patents Assigned to Dong Wha Pharm. Co., Ltd.
-
Publication number: 20230143345Abstract: The present invention relates to a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising an organic solvent extract of Justicia procumbens as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-A as an effective ingredient, a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising justicidin-B as an effective ingredient, or a pharmaceutical composition for preventing or treating COVID-19 diseases, comprising 6? hydroxyl justicidin-B as an effective ingredient, and a food composition thereof for preventing or ameliorating COVID-19 diseases. According to the present invention, an anhydrous ethanol extract of Justicia procumbens, justicidin-A, justicidin-B, and 6? hydroxyl justicidin-B effectively inhibit SARS-CoV-2 virus, and thus may effectively prevent, treat, or ameliorate diseases caused by SARS-CoV-2 virus.Type: ApplicationFiled: March 19, 2021Publication date: May 11, 2023Applicant: DONG WHA PHARM. CO., LTD.Inventors: Joo Byoung YOON, Yun Ha HWANG, Ma Se LEE, Hyun Yong LEE
-
Patent number: 11028090Abstract: Provided are a novel [1,2,4]triazolo[4,3-a]quinoxaline derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating bromodomain extra-terminal (BET) protein-related diseases including cancer and autoimmune diseases, containing the same as an active ingredient.Type: GrantFiled: January 25, 2018Date of Patent: June 8, 2021Assignees: Dong Wha Pharm. Co., Ltd., Korea Research Institute of Chemical TechnologyInventors: Kwangho Lee, Gildon Choi, Imran Ali, Joo Yun Lee, Jin Soo Lee, Whui Jung Park, Yong Tae Kim, Seung Hwan Kim, Jung Hwan Kim, Jae-Kyung Lim
-
Patent number: 10869904Abstract: The present invention relates to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L. as an active ingredient, and to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L., the extract comprising any one or more of justicidin A, justicidin B, justicidin C and phyllamyricin C, and also to a food composition for preventing or treating respiratory disease, which comprises the alcohol or organic solvent extract. The composition comprising the Justicia procumbens L. extract according to the present invention may inhibit abnormal overproliferation of splenocytes, may inhibit the secretion of allergic inflammatory cytokines, and exhibits an expectorant effect and an airway constriction inhibitory effect. Thus, it may effectively prevent, treat or improve respiratory disease.Type: GrantFiled: April 13, 2017Date of Patent: December 22, 2020Assignee: DONG WHA PHARM. CO., LTD.Inventors: Joo Byoung Yoon, Hyun Yong Lee, Ji Hyun Youm, Kwang Hyun Kim, Ji Hyun Jeon, Hwan Bong Chang, Ji Young Woo, Mi Hee Yoon, Min Soo Choi, Dong Rack Choi
-
Patent number: 10688143Abstract: The present invention relates to a pharmaceutical composition, food composition and cosmetic composition for preventing, treating, or improving allergic diseases comprising extract or fraction of a plant of the Justicia genus as an active ingredient. The extract or a fraction of a plant of the Justicia genus according to the present invention can inhibit IgE antibody secretion and the degranulation of mast cells and basophils, and exhibits an excellent anti-allergic effect, and thus can effectively prevent, treat, or improve allergic diseases.Type: GrantFiled: October 16, 2015Date of Patent: June 23, 2020Assignee: DONG WHA PHARM. CO., LTD.Inventors: Joo Byoung Yoon, Hyun Yong Lee, Ji Hyun Youm, Kwang Hyun Kim, Ji Hyun Jeon, Hwan Bong Chang, Yun Ha Hwang, Seung Kyoo Seong, Dong Rack Choi
-
Publication number: 20190134126Abstract: The present invention relates to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L. as an active ingredient, and to a pharmaceutical composition for preventing or treating respiratory disease, which comprises an alcohol or organic solvent extract of Justicia procumbens L., the extract comprising any one or more of justicidin A, justicidin B, justicidin C and phyllamyricin C, and also to a food composition for preventing or treating respiratory disease, which comprises the alcohol or organic solvent extract. The composition comprising the Justicia procumbens L. extract according to the present invention may inhibit abnormal overproliferation of splenocytes, may inhibit the secretion of allergic inflammatory cytokines, and exhibits an expectorant effect and an airway constriction inhibitory effect. Thus, it may effectively prevent, treat or improve respiratory disease.Type: ApplicationFiled: April 13, 2017Publication date: May 9, 2019Applicant: DONG WHA PHARM. CO., LTD.Inventors: Joo Byoung Yoon, Hyun Yong Lee, Ji Hyun Youm, Kwang Hyun Kim, Ji Hyun Jeon, Hwan Bong Chang, Ji Young Woo, Mi Hee Yoon, Min Soo Choi, Dong Rack Choi
-
Patent number: 10172899Abstract: The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.Type: GrantFiled: October 27, 2017Date of Patent: January 8, 2019Assignee: DONG WHA PHARM. CO., LTD.Inventors: Da-Ae Park, Yoon-Young Chang, Kwang-Hyun Kim, Sang-Ho Lee, Chan-Seok Jeon, Hyun-Yong Lee
-
Publication number: 20180055902Abstract: The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.Type: ApplicationFiled: October 27, 2017Publication date: March 1, 2018Applicant: DONG WHA PHARM. CO., LTD.Inventors: Da-Ae PARK, Yoon-Young CHANG, Kwang-Hyun KIM, Sang-Ho LEE, Chan-Seok JEON, Hyun-Yong LEE
-
Publication number: 20170360862Abstract: The present invention relates to a pharmaceutical composition, food composition and cosmetic composition for preventing, treating, or improving allergic diseases comprising extract or fraction of a plant of the Justicia genus as an active ingredient. The extract or a fraction of a plant of the Justicia genus according to the present invention can inhibit IgE antibody secretion and the degranulation of mast cells and basophils, and exhibits an excellent anti-allergic effect, and thus can effectively prevent, treat, or improve allergic diseases.Type: ApplicationFiled: October 16, 2015Publication date: December 21, 2017Applicant: DONG WHA PHARM. CO., LTD.Inventors: Joo Byoung Yoon, Hyun Yong Lee, Ji Hyun Youm, Kwang Hyun Kim, Ji Hyun Jeon, Hwan Bong Chang, Yun Ha Hwang, Seung Kyoo Seong, Dong Rack Choi
-
Publication number: 20170095520Abstract: The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.Type: ApplicationFiled: March 20, 2015Publication date: April 6, 2017Applicant: DONG WHA PHARM. CO., LTD.Inventors: Da-Ae PARK, Yoon-Young CHANG, Kwang-Hyun KIM, Sang-Ho LEE, Chan-Seok JEON, Hyun-Yong LEE
-
Publication number: 20160346307Abstract: The present invention relates to a pharmaceutical composition for an anticancer adjuvant containing a receptor-interacting protein kinase-3 (RIP3) protein expression inducing agent or activator as an active ingredient. The present invention also provides a method for enhancing cancer cell death, comprising administering a RIP3 protein expression inducing agent or activator in combination with an anticancer drug to cancer cells. Additionally, the present invention relates to a method for screening an anticancer adjuvant which enhances anticancer drug sensitivity by promoting RIP3 expression; and a method for monitoring anticancer drug sensitivity based on RIP3 expression. Therefore, in the case of patients lacking RIP3 expression, the use of a conventional chemotherapeutic agent after inducing RIP3 expression by pretreatment with a demethylating agent may be an effective therapeutic strategy.Type: ApplicationFiled: November 25, 2014Publication date: December 1, 2016Applicant: DONG WHA PHARM. CO., LTD.Inventors: You Sun KIM, Gi Bang KOO, Jung Ho YUN, Woo Jung KIM, Yu Na JO
-
Patent number: 8637097Abstract: Disclosed is a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.Type: GrantFiled: December 22, 2011Date of Patent: January 28, 2014Assignee: Dong Wha Pharm. Co., Ltd.Inventors: Jei-Man Ryu, Moon-Jung Leem, Yang-Kook Roh, Hwan-Bong Chang, Seong-Jun Oh, Hyun-Yong Lee, Sae-Kwang Ku, Hee-Bog Yang, Jung-Woo Rhee, Yun-Jung Kim, Joo Byoung Yoon
-
Publication number: 20140018552Abstract: The present invention provides an AGE inhibitor and a health functional food for inhibiting an occurrence of diabetic complications. Particularly, the present invention comprises a compound selected from the group consisting of mulberrofuran G, mulberrofuran K, kuwanon G, kuwanon Z, oxyresveratrol, 2?,4?,5,7-tetrahydroxyflavanone, morusignin L and dihydromorin isolated from Morus Bark as an active ingredient. The compounds disclosed above inhibit the production of AGE which is a causative substance of diabetic complications. Thus, the compounds could be used as an AGE inhibitor and a health functional food for inhibiting diabetic nephropathy, diabetic retinopathy and diabetic neuropathy.Type: ApplicationFiled: March 26, 2012Publication date: January 16, 2014Applicant: Dong Wha Pharm. Co., Ltd.Inventors: Hwan Bong Chang, Joobyoung Yoon, Hyun Yong Lee, Hyun Sik Choi, Hyung Bok Lee
-
Publication number: 20120093942Abstract: Disclosed is a pharmaceutical composition and health food comprising herb extracts of one or more herbs selected from the group consisting of Puerariae Radix, Bombycis corpus and Araliae Continentalis Radix. The herb medicine of this invention comprising a single or mixed composition may be useful for the prevention and treatment of renal diseases as well as improvement of renal functions.Type: ApplicationFiled: December 22, 2011Publication date: April 19, 2012Applicant: Dong Wha Pharm. Co., Ltd.Inventors: Jei-Man RYU, Moon-Jung LEEM, Yang-Kook ROH, Hwan-Bong CHANG, Seong-Jun OH, Hyun-Yong LEE, Sae-Kwang KU, Hee-Bog YANG, Jung-Woo RHEE, Yun-Jung KIM, Joo Byoung YOON
-
Publication number: 20100029595Abstract: The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.Type: ApplicationFiled: July 31, 2009Publication date: February 4, 2010Applicant: Dong Wha Pharm. Co., Ltd.Inventors: Jei Man RYU, Jin Soo LEE, Jae Hoon PARK, Yun-Ha HWANG, Duk Kyun CHUNG
-
Publication number: 20100029596Abstract: The present invention provides a method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivative or its salt, and bisphosphonate for the purpose of using simultaneously, separately, or sequentially as active ingredients. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of the benzamidine derivative and the bisphosphonate compound exhibits excellent inhibitory effect on osteoclast differentiation than the total effect of each individual treatment, thereby being used for the prevention or treatment of osteoporosis.Type: ApplicationFiled: July 31, 2009Publication date: February 4, 2010Applicant: Dong Wha Pharm, Co. Ltd.Inventors: Jei Man RYU, Jin Soo Lee, Yun-Ha Hwang, Young G. Jin, Ki Y. Kim