Abstract: Disclosed are aspartic acid salts of 1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid, methods for preparing the same, and antimicrobial pharmaceutical compositions comprising the same.
Type:
Grant
Filed:
April 14, 2008
Date of Patent:
December 4, 2012
Assignee:
Dong Wha Pharmaceutical Co. Ltd.
Inventors:
Jei Man Ryu, Dong Rack Choi, Jin Yang, Sue Hye Yoon, Seung Hwan Kim, Sae Kwang Ku
Abstract: This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prophylaxis and treatment of osteoporosis and more particularly, to the use of 4-{5-[4-(5-isoproply-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1 as a pharmaceutical composition for the prophylaxis and treatment of osteoporosis.
Type:
Grant
Filed:
January 19, 2010
Date of Patent:
August 14, 2012
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Hong-Suk Suh, Jin Soo Lee, Pan-Soo Kim, Yun-Ha Hwang, Jei Man Ryu, Yong-Ho Chung, Eun-Joo Kim, Do-Hui Kim, Yong-Youp Park
Abstract: A method of treating osteoporosis comprising administering to a subject a composition comprising a compound, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or a salt thereof, is described. A method of inhibiting osteoclast activity and stimulating osteoblast activity in a subject also is described.
Type:
Grant
Filed:
January 19, 2010
Date of Patent:
July 24, 2012
Assignee:
Dong Wha Pharmaceutical Co., Ltd
Inventors:
Hong-Suk Suh, Jin Soo Lee, Pan-Soo Kim, Yun-Ha Hwang, Jei Man Ryu, Yong-Ho Chung, Eun-Joo Kim, Do-Hui Kim, Yong-Youp Park
Abstract: The present invention relates to novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same. The novel benzamidine derivatives of the present invention are useful for the prevention and treatment of osteoporosis, bone fractures and allergic inflammatory diseases.
Type:
Grant
Filed:
August 4, 2005
Date of Patent:
May 15, 2012
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jin Soo Lee, Seok Hoon Ahn, Young Goo Jin, Sang Mi Jin, Whui-Jung Park, Sae Kwang Ku, Yun Ha Hwang, Pan Soo Kim, Sun Shin Yi, Jei Man Ryu
Abstract: The object of the present invention is to provide a therapeutic agent or a prophylactic agent for a disease resulting from an abnormal bone metabolism, especially osteoporosis which is more effective than conventional agents. Excellent therapeutic effect or prophylactic effect on a disease resulting from an abnormal bone metabolism, especially osteoporosis, compared with the effect in administration of each compound alone can be obtained by the combination of an N-hydroxybenzamidine derivative represented by Formula (I) or a salt thereof with an activated vitamin D or a prodrug thereof.
Type:
Application
Filed:
January 29, 2010
Publication date:
December 15, 2011
Applicants:
DONG WHA PHARMACEUTICAL CO ., LTD., TEIJIN PHARMA LIMITED
Abstract: N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
Type:
Grant
Filed:
April 21, 2008
Date of Patent:
October 18, 2011
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jin Soo Lee, Soon Ki Cho, Seoung Kyoo Sung, Young Goo Jin, Jae Hoon Park, Bo Kyung Kim, Ja Hyun Cha, Eun Hee Cho, Jei Man Ryu
Abstract: The present invention provides a method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivative or its salt, and bisphosphonate for the purpose of using simultaneously, separately, or sequentially as active ingredients. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of the benzamidine derivative and the bisphosphonate compound exhibits excellent inhibitory effect on osteoclast differentiation than the total effect of each individual treatment, thereby being used for the prevention or treatment of osteoporosis.
Type:
Grant
Filed:
July 31, 2009
Date of Patent:
August 30, 2011
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jei Man Ryu, Jin Soo Lee, Yun-Ha Hwang, Young G. Jin, Ki Y. Kim
Abstract: The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.
Type:
Grant
Filed:
July 31, 2009
Date of Patent:
June 21, 2011
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jei Man Ryu, Jin Soo Lee, Jae Hoon Park, Yun-Ha Hwang, Duk Kyun Chung
Abstract: The present invention relates to a novel benzamidine derivative, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzamidine derivative of the present invention effectively inhibits osteoclast differentiation at an extremely low concentration, and greatly increases the trabecular bone volume, and thus it can be advantageously used for the prevention and treatment of osteoporosis.
Type:
Grant
Filed:
January 31, 2007
Date of Patent:
May 17, 2011
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jei Man Ryu, Jin Soo Lee, Young Goo Jin, Ki Young Lee, Jae Hoon Park, Yun Ha Hwang, Sae Kwang Ku
Abstract: Disclosed herein is a composition for the treatment bone fracture comprising N-hydroxy-4-{5-[4-( 5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxyl-benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, and increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
April 12, 2011
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Jei Man Ryu, Jin Soo Lee, Sae Kwang Ku, Jung Woo Lee, Hee Bog Yang
Abstract: The present invention relates to novel benzamidine derivatives, a process for the preparation thereof and a pharmaceutical composition for preventing or treating osteoporosis comprising the same. The benzamidine derivatives of the present invention effectively inhibit osteoclast differentiation at an extremely low concentration, and thus can be advantageously used for the prevention and treatment of osteoporosis.
Type:
Application
Filed:
July 28, 2008
Publication date:
September 30, 2010
Applicant:
DONG WHA PHARMACEUTICAL CO. LTD.
Inventors:
Jei Man Ryu, Jin Soo Lee, Young Goo Jin, Jae Hoon Park, Bo Kyung Kim, Dae Yeon Won, Yun-Ha Hwang, Ki Yoon Kim, Sae Kwang Ku
Abstract: N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same are described.
Type:
Application
Filed:
April 21, 2008
Publication date:
May 6, 2010
Applicant:
DONG WHA PHARMACEUTICAL CO., LTD.
Inventors:
Jin Soo Lee, Soon Ki Cho, Seoung Kyoo Sung, Young Goo Jin, Jae Hoon Park, Bo Kyung Kim, Ja Hyun Cha, Eun Hee Cho, Jei Man Ryu
Abstract: This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prevention and treatment of osteoporosis and more particularly, to the use of 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-{5-[4-(5-iso-propyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1, which is known as an antagonist of leukotriene-B4 receptor, as a pharmaceutical composition for the prevention and treatment of osteoporosis. [Formula 1], wherein, R is a hydrogen atom or a hydroxy group.
Type:
Grant
Filed:
March 19, 2002
Date of Patent:
February 16, 2010
Assignee:
Dong Wha Pharmaceutical Co., Ltd.
Inventors:
Hong-Suk Suh, Jin-Soo Lee, Pan-Soo Kim, Yun-Ha Hwang, Jei-Man Ryu, Yong-Ho Chung, Eun-Joo Kim, Do-Hui Kim, Yong-Youp Park