Abstract: Disclosed are aspartic acid salts of 1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid, methods for preparing the same, and antimicrobial pharmaceutical compositions comprising the same.
Type:
Application
Filed:
April 14, 2008
Publication date:
July 22, 2010
Applicant:
DONG WHA PHARMACEUTICAL IND. CO. LTD
Inventors:
Jei Man Ryu, Dong Rack Choi, Jin Yang, Sue Hye Yoon, Seung Hwan Kim, Sae Kwang Ku
Abstract: This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
September 8, 2009
Assignee:
Dong Wha Pharmaceutical Ind. Co., Ltd.
Inventors:
Jin Soo Lee, Seok Hoon Ahn, Young Goo Jin, Jae Hoon Park, Dong Hyuk Shin, Eun Hee Cho, Hwan Bong Chang, Young Ho Jung
Abstract: Disclosed herein is a composition for the treatment bone fracture comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxyl-benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, and increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.
Type:
Application
Filed:
July 5, 2005
Publication date:
November 20, 2008
Applicant:
DONG WHA PHARMACEUTICAL IND. CO., LTD.
Inventors:
Jei Man Ryu, Jin Soo Lee, Sae Kwang Ku, Jung Woo Lee, Hee Bog Yang