Abstract: A method for preparing a pair of personalized three-dimensional (3D) printing medical isolation goggles includes the steps of S1: establishing a medical isolation goggles matrix; S2: acquiring the facial data of a user; S3: establishing a personalized medical isolation goggles model; S4: performing additive manufacturing, wherein a pair of medical isolation goggles is provided with high personalized fitness and high breathability for patients with eye diseases such as conjunctivitis, virus-susceptible patients, front-line clinical medical workers and related workers, and the compression damage to the face caused by the wearing of the medical isolation goggles for a long time is reduced in terms of fitness and comfort, where the medical isolation goggles are manufactured in a mode of additive manufacturing, small-batch rapid production can be performed after data merging, and a large number of processes and costs are reduced in the production cycle.