Abstract: The present invention relates to kartogenin-conjugated chitosan particles with an improved sustained release property and biocompatibility. Effects of increases in biocompatibility, chondrogenic differentiation efficiency and retention time in the joints were confirmed by using kartogenin-chitosan microparticles or kartogenin-chitosan nanoparticles of the present invention, and thus targeted treatment, in the prevention or treatment of bone diseases, is enabled through a more fundamental approach.
Type:
Grant
Filed:
August 11, 2015
Date of Patent:
September 4, 2018
Assignee:
DONGGUK UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION