Patents Assigned to Dong Kook Pharmaceutical Co., Ltd.
-
Patent number: 7244591Abstract: Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a human parathyroid hormone gene in their genomes. Culturing the novel strains results in the secretion of intact hPTH into culture media at high yield.Type: GrantFiled: August 27, 2001Date of Patent: July 17, 2007Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Sang Ki Rhee, Hyun Ah Kana, Bong Hyun Chung, Su Min Ko
-
Patent number: 7192743Abstract: Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution conditions and recovering highly pure teicoplanin using activated carbon and/or ultrafiltration. In this regard, the method can further include ultrafiltration as pre-treatment before the culture broth is adsorbed into the porous adsorption resin so as to increase the purity of teicoplanin.Type: GrantFiled: April 15, 2005Date of Patent: March 20, 2007Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Deok-Joong Youn, Ho-Myeung Ryu, Kang-Hee Lee, Dae-Sung Lim, In-Kyu Lee, Sung-Woo Kim, Hyun-Ki Paeng, Kyung-Hoi Cha
-
Publication number: 20050245481Abstract: Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution conditions and recovering highly pure teicoplanin using activated carbon and/or ultrafiltration. In this regard, the method can further include ultrafiltration as pre-treatment before the culture broth is adsorbed into the porous adsorption resin so as to increase the purity of teicoplanin.Type: ApplicationFiled: April 15, 2005Publication date: November 3, 2005Applicant: DONG KOOK PHARMACEUTICAL CO., LTD.Inventors: Deok-Joong Youn, Ho-Myeung Ryu, Kang-Hee Lee, Dae-Sung Lim, In-Kyu Lee, Sung-Woo Kim, Hyun-Ki Paeng, Kyung-Hoi Cha
-
Patent number: 6274559Abstract: Compositions and methods of treating or preventing hepatotoxicity utilizing asiatic acid derivatives of Formula 1 are disclosed.Type: GrantFiled: August 27, 1999Date of Patent: August 14, 2001Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Sang Sup Jew, Hyeung Geun Park, Hee Doo Kim, Young Hoon Jung, Young Choong Kim, Hong Pyo Kim, Mi Kyeong Lee, Hee Sung Choi, Eung Seok Lee, Chi Hyoung Yoo, Doo Yeon Lim, Jeong Hoon Kim, Hee Man Kim
-
Patent number: 6169112Abstract: Disclosed is the use of 2-oxoasiatic acid in the treatment of dementia or cognitive disorders.Type: GrantFiled: May 25, 1999Date of Patent: January 2, 2001Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Sang Sup Jew, Hyeung Geun Park, Hee Doo Kim, Young Hoon Jung, Young Choong Kim, So Ra Kim, Sung Ki Seo, Tae Gyu Nam, Ducky Han, Chi Hyoung Yoo, Doo Yeon Lim, Jeong Hoon Kim, Hee Man Kim, Jae Ho Park, Pil Jong Shim, Ju Eun Jung, Hee Young Beom
-
Patent number: 6143900Abstract: The present invention relates to stereoselective synthetic method of oxazoline derivative. More particularly, it relates to a synthetic method of oxazoline derivative having the structure of formula I. ##STR1## wherein R represents phenyl, benzyl, methyl, ethyl, isopropyl, isobutyl, cyclohexyl or cyclohexylmethyl.Type: GrantFiled: October 26, 1999Date of Patent: November 7, 2000Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Won Hun Ham, Kyung Seok Choi, Han Won Lee, Sung Ki Seo, Jin Kyu Park, Ki Young Lee, Yong Hyun Kim
-
Patent number: 6127546Abstract: The present invention relates to a process for the preparation of an oxazoline compound which is easily chemically converted to a beta-amino-alpha-hydroxy acid or a gamma-amino-beta-hydroxy acid. The method comprises producing a compound of the following formula (4) using .alpha.-amino acid. The produced compound (4) is subjected to an intramolecular cyclization to produce an oxazoline compound of the following formula (3). The oxazoline compound (3) is oxidized at a vinyl group with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (1) which is easily chemically converted to a beta-amino-alpha-hydroxy acid. Alternatively, the oxazoline compound (3) may also be treated with 9-borabiclo[3.3.1]nonane such that a hydroxy group is introduced into the end of the vinyl group of the oxazoline compound(3). The introduced end hydroxy group is oxidized with RuCl.sub.3 or NaIO.sub.Type: GrantFiled: February 29, 2000Date of Patent: October 3, 2000Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Jin Kyu Park, Kyung Seok Choi, Han Won Lee, Sung Ki Seo, Won Hun Ham, Chang Young Oh, Kee Young Lee, Yong Hyun Kim, Min Sung Park
-
Patent number: 6071898Abstract: Asiatic acid derivatives having a modified A-ring, as represented by formula 1 are disclosed. ##STR1## Pharmaceutical compositions and methods of treating cancer and hepatotoxicity utilizing compounds of formula 1 are also disclosed.Type: GrantFiled: May 25, 1999Date of Patent: June 6, 2000Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Sang Sup Jew, Hyeung Geun Park, Hee Doo Kim, Young Hoon Jung, Young Choong Kim, Hong Pyo Kim, Mi Kyeong Lee, Hee Sung Choi, Eung Seok Lee, Chi Hyoung Yoo, Doo Yeon Lim, Jeong Hoon Kim, Hee Man Kim, Sung Ki Seo, Tae Gyu Nam, Ducky Han, Pil Jong Shim, Ju Eun Jung, Hee Young Beom
-
Patent number: 5855904Abstract: The present invention relates to a biodegradable sustained release preparation for treating periodontitis, especially containing polysaccharide. The core of the preparation according to the present invention consists of medicine and polysaccharide, i.e. sodium alignate, and is coated with cationic chitosan. By the function of chitosan building the coating of the preparation, the medicine is slowly released, and the carrier is completely decomposed by lysozyme in vivo after the release of the medicine.Type: GrantFiled: April 3, 1997Date of Patent: January 5, 1999Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Chong Pyoung Chung, Seung Jin Lee
-
Patent number: 5834437Abstract: The object of the present invention is to provide asiatic acid derivatives, its pharmaceutically acceptable salts or esters.Asiatic acid, its trisaccharide asiaticoside and mddecassic acid, extracted from Centella asiatica have been used for a long time in the management of skin scars and chronic ulcers. In this invention, asiatic acid derivatives synthesized from asiatic acid show excellent wound-healing properties.Type: GrantFiled: December 1, 1995Date of Patent: November 10, 1998Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Sang-Sup Jew, Hee-Doo Kim, Young-Hoon Jung, Eun-Hee Park, Sung-Ki Seo, Tae-Gyu Nam, Duc-Ky Hahn, Jae-Ho Park, Pil-Jong Sim, Min-Jung Lim, Kyung-Haw Lim
-
Patent number: 5792885Abstract: A preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid includes the steps of: mixing N-alkoxycarbonyl-.beta.-alanine, phosphorous chloride and phosphorous acid in the ratio of 1:1:1.about.1:3:3 in a reaction solvent, xylene at 70.degree.-140.degree. C.; hydrolyzing; and obtaining 3-amino-1-hydroxypropane-1,1-diphosphonic acid as a product, thus decreasing the production of unidentified by-products and giving and low production cost by using xylene instead of chlorobenzene as a reaction solvent.Type: GrantFiled: August 13, 1997Date of Patent: August 11, 1998Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Won Hun Ham, Young Hun Jung, Chang Young Oh, Kee Young Lee, Yong Hyun Kim
-
Patent number: 5789204Abstract: The object of this invention is to provide a biosorbent for heavy metals having polyaminosaccharide sodiumphosphate as main ingredient prepared from microbial biomass using Aspergillus, Penicillium, Trichoderma or Micrococcus genus originating from industrial fermentations and biological treatment plants.Type: GrantFiled: January 16, 1996Date of Patent: August 4, 1998Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Leonid Semionovich Kogtev, Jin Kyu Park, Jin Kyuk Pyo, Young Keun Mo
-
Patent number: 5698104Abstract: Disclosed herein is a process for purifying hirudin from a solution containing hirudin and other substances, characterized in that the process comprises a step of subjecting the solution to a metal ion affinity chromatography wherein copper ion (Cu.sup.++) is used as a metal ion and a phosphate buffer is used as an eluent.Type: GrantFiled: September 6, 1995Date of Patent: December 16, 1997Assignees: Dong Kook Pharmaceutical Co., Ltd., Korean Institute of Science and TechnologyInventors: Sang Ki Rhee, Bong Hyun Chung, Eui Sung Choi, Jung Hoon Sohn, Deok Joong Youn, Myung Kuk Kim, Hae Don Lee
-
Patent number: 5654321Abstract: The present invention relates to a novel 2-chloro-3-arylamino-1,4-naphthoquinone derivative represented by the following formula (I), which has a potent inhibitory activity against platelet aggregation: ##STR1## in which X represents nitrogen (N) or carbon (C) atom andR represents cyano, orR can further represent alkyl, carboxyl or acyl when X represents nitrogen (N) atom,and to a process for preparing thereof and to a pharmaceutical composition for inhibiting blood coagulation which comprises the compound of formula (I) as an active ingredient.Type: GrantFiled: January 30, 1996Date of Patent: August 5, 1997Assignee: Dong Kook Pharmaceutical Co. Ltd.Inventors: Chang-Kiu Moon, Chung-Kyu Ryu
-
Patent number: 5599553Abstract: The present invention provides a local drug delivery film, which is characterized by comprising, as release control component, polymer mixture consistiong of polycaprolactone having molecular weight of 30,000-60,000 and polycaprolactone having molecular weight less than 1,000 in a ratio of 1:1-4:1, and as active component, periodontal therapeutic agent. The present local drug delivery film is prepared by admixing homogeneously active component with melted polymer mixture and pressing into film. And the present drug delivery film has excellent sustained release pattern and excellent treatment effect in oral disease with release amount 1.7 mg. which is 0.12% of prescription amount, 1400 mg. for adults during 7 days and provides the application stability into human body.Type: GrantFiled: February 28, 1995Date of Patent: February 4, 1997Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventor: Chong P. Chung
-
Patent number: 5532381Abstract: This invention relates to novel processes for preparing substituted pyrrolizine compounds. More particularly, it relates to novel processes for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylate of the following formula (I) from pyrrole.Type: GrantFiled: November 30, 1994Date of Patent: July 2, 1996Assignee: Dong Kook Pharmaceutical Co., Ltd.Inventors: Yong H. Kim, Hee S. Park, Dong H. Lee
-
Patent number: 5463046Abstract: The present invention relates to new 1-.beta.-methyl-2-thiolic carbapenem derivatives represented by the following general formula (I) and producing method thereof. ##STR1## The above-mentioned compound is very stable against DHP-1 enzyme due to effective shielding of carbapenem ring structually and is highly effective in both gram-positive and gram-negative microorganism, especially has a remarkable effect on the Pseudomonas aeruginosa known as a disease germ having strong resistance.Type: GrantFiled: November 19, 1993Date of Patent: October 31, 1995Assignees: Dong Kook Pharmaceutical Co., Ltd., Ki-Beom KwonInventors: Jung H. Cho, Chang H. Oh, Ki H. Nam
-
Patent number: 5414156Abstract: This invention relates to the process for producing ortho-isopropylated phenol derivatives having following general formula (VIII). ##STR1## (in the above formula, R.sub.1 is a hydrogen or a low alkyl group of C.sub.1 -C.sub.4)A process for producing ortho-isopropylated phenol derivatives (VIII) of the present invention is characterized by obtaining position isomer desired by means of Claisen rearrangement of phenyl allyl ether without catalyst in atmosphere, and then obtaining only one isomer by oxidation and reduction of the above-obtained position isomer. According to the present invention, ortho-alkylated phenol derivatives (VIII) having high purity at low temperature and low pressure can be prepared without producing a by-product and requirement of the complicated separation procedure.Type: GrantFiled: May 10, 1994Date of Patent: May 9, 1995Assignees: Dong Kook Pharmaceutical Co., Ltd., Ki-Beom KwonInventors: Jung H. Cho, Kie H. Nam, Wan S. Kim