Patents Assigned to Dong Wha Pharm, Ind. Co., Ltd.
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Publication number: 20080166297Abstract: The present invention relates to a radionuclide-chitosan complex solution and its preparation method, and more particularly to the radionuclide-chitosan complex solution having a viscosity of 300˜2,400 cps, comprising an aqueous chitosan solution or a freeze-dried chitosan labeled with a radionuclide. The radionuclide-chitosan complex solution according to the present invention has a stable gelation state at a target region when injected into the body while maintaining a labeling yield of radioisotope to chitosan above 99%. Side effects may be minimized and treatment efficiency may be increased when injected to a patient.Type: ApplicationFiled: December 1, 2005Publication date: July 10, 2008Applicants: DONG WHA PHARM. IND. CO., LTD., KOREAN ATOMIC ENERGY RESEARCH INSTITUTEInventors: Jei-Man Ryu, Dong-Hyuk Shin, Seung-Kyoo Seong, Hee-Bog Yang, Young-Jun Song, Eun-Jung Bae, Kyung-Bae Park, Byung-Chul Shin
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Publication number: 20080031811Abstract: The present invention relates to a method for preparing a radioactive film for local radioactive treatment. More particularly, the present invention relates to a method for preparing a radioactive film comprising the steps of; dissolving 0.1˜14.5 weight % of a stable nuclide and 13˜32.5 weight % of a film-forming base for the total amount of a solvent in the solvent; applying a stable nuclide solution on a release paper by a coater and drying; and irradiating a stable nuclide film with neutrons in a nuclear reactor. A method for preparing a radioactive film according to the present invention provides a radioactive film having a uniform distribution of radionuclides and an even thickness. Therefore, the therapeutic efficacy of the radioactive film for selective treatment of a lesion may be maximized by attaching the radioactive film on a patient's skin or a mucous membrane and by direct radioactive radiation.Type: ApplicationFiled: September 12, 2005Publication date: February 7, 2008Applicants: DONG WHA PHARM. IND. CO., LTD., KOREA ATOMIC ENERGY RESEARCH INSTITUTEInventors: Jei-Man Ryu, Yu-Eun Kim, Seung-Kyoo Seong, Dong-Hyuk Shin, Byung-Ho Cho, Young-Jun Song, Kyung-Bae Park, Byung-Chul Shin
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Publication number: 20070254930Abstract: The present invention relates to an oral preparation of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxyl-benzamidine having improved bioavailability. More particularly, the present invention relates to an oral preparation comprising: N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salt thereof; and one or more carbonates selected from the group consisting of alkalimetal carbonate, alkalimetal bicarbonate and alkaline earth metal carbonate, and/or one or more disintegrants selected from the group consisting of sodium starch glycolate, carmellose calcium and croscarmellose sodium. The oral preparation according to the present invention inhibits gelation of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salt thereof in the early stage of release, which increases dissolution rate and remarkably raises bioavailability.Type: ApplicationFiled: November 22, 2005Publication date: November 1, 2007Applicant: DONG WHA PHARM. IND. CO., LTD.Inventors: Jei Ryu, Soon Cho, Se Jung, Seung-Kyoo Seong, Eun Cho, Seok Ahn, Yun-Jung Kim
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Patent number: 6858727Abstract: There is disclosed an azetidinone compound of the formula (I): wherein R is hydrogen, or a hydroxy protecting group, R1 and R2 are each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; R3 is lower alkyl or —COO(lower alkyl) R4 is phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1??-methylcarbapenem-type antibacterial agent.Type: GrantFiled: August 6, 2001Date of Patent: February 22, 2005Assignees: Dong Wha Pharm, Ind. Co., Ltd., Korea Research Institute of Chemical TechnologyInventors: Cheol-hae Lee, Bong-jin Kim, Do-kyu Pyun, Won-jang Jeong, Jae-hak Kim, Hee-jung Chung, Hyun-jung Kwak, Eun-jung Kim, Shin-seup Song, Yong-ho Chung
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Patent number: 6762189Abstract: The present invention relates to novel 5-pyrimidinecarboxamide derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 5-pyrimidinecarboxamide derivatives and their pharmacutically able salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 5-pyrimidinecarboxamide derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).Type: GrantFiled: May 24, 2002Date of Patent: July 13, 2004Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung June Yoon, Sang Wook Lee, Nam Doo Kim, Yong Kyun Park, Geun Hyung Lee, Jong Woo Kim, Sang Jin Park, Hee Jeoung Park, Hwan Bong Jang
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Patent number: 6753430Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4methyl-3-(Z)-alkoxyiminopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.Type: GrantFiled: June 20, 2003Date of Patent: June 22, 2004Assignee: Dong Wha Pharm. Ind. Co., LtdInventors: Sung June Yoon, Yong Ho Chung, Chi Woo Lee, Jin Soo Lee, Nam Doo Kim, Yoon Ho Jin, Wan Jin Song, Ik Hoe Kim, Wang Yong Yang, Dong Rack Choi, Jung Han Shin
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Patent number: 6743795Abstract: The present invention relates to novel 3-nitropyridine derivatives, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same as active ingredients. Methods of preparing the derivatives and pharmaceutical compositions containing the same are also disclosed. The 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as therapeutic agents as well as preventive agents for hepatitis B and acquired immune deficiency syndrome (AIDS).Type: GrantFiled: May 24, 2002Date of Patent: June 1, 2004Assignee: Dong Wha Pharm. Ind. Co. Ltd.Inventors: Sung June Yoon, Sang Wook Lee, Nam Doo Kim, Yong Kyun Park, Geun Hyung Lee, Jong Woo Kim, Sang Jin Park, Hee Jeoung Park, Dong Hyuk Shin
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Patent number: 6649763Abstract: The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyirninopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.Type: GrantFiled: November 16, 2001Date of Patent: November 18, 2003Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung June Yoon, Yong Ho Chung, Chi Woo Lee, Jin Soo Lee, Nam Doo Kim, Yoon Ho Jin, Wan Jin Song, Ik Hoe Kim, Wang Yong Yang, Dong Rack Choi, Jung Han Shin
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Patent number: 6608058Abstract: The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The 6-methylnicotinamide derivatives of the present invention exhibit their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV) and hepatitis C virus (HCV), such that they can be used for hepatitis B, hepatitis C and acquired immune deficiency syndrome (AIDS).Type: GrantFiled: October 10, 2002Date of Patent: August 19, 2003Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung-June Yoon, Sang-Wook Lee, Jin-Soo Lee, Nam-Doo Kim, Geun-Hyung Lee, Hak-Dong Lee, Jong-Woo Kim, Sang-Jin Park, Hee-Jeong Park
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Patent number: 6488954Abstract: The present invention relates to a liquid suppository composition comprising diclofenac sodium, poloxamer and at least one polymer select from the group consisting of polyethylene oxide and polyvinylpyrrolidone. The composition provides the advantages of. (1) a feel of foreign matter or discomfort does not occur when the composition is rectally administered; and (2) administration is easy and after rectal administration, the composition is neither leaked out from the anus nor shifted into the end of large intestine.Type: GrantFiled: August 24, 2001Date of Patent: December 3, 2002Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung June Yoon, Jei Man Ryu, Jae Hee Jung, Su Jin Cho
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Patent number: 6150390Abstract: The present invention relates to a novel 3-amino-1,2-benzoisoxazole derivatives, represented by Formula I, LTB-4[leukotriene-B-4; 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid] receptor antagonist, process for preparation thereof, and use thereof for LTB-4 receptor antagonist or therapeutics for osteoporosis. ##STR1## (in which n is integer of 3-5).Type: GrantFiled: July 21, 1999Date of Patent: November 21, 2000Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Hong-Suk Suh, Jae-Ha Ryu, Yong-Nam Han, Sung-June Yoon, Jong-Woo Kim
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Patent number: 6071734Abstract: The present invention relates to hepatitis B virus (hereinafter it refers to HBV) polymerase containing a histidine tag, RNase H enzyme derived from HBV polymerase and processes for preparation thereof. More particularly, the present invention relates to recombinant HBV polymerase, its RNase H domain with enzyme activity, expression vectors producing the enzymes in E. coli and processes for preparing the HBV polymerase and the RNase H enzyme which can be easily purified due to their histidine tags. And the present invention relates to uses of the HBV polymerase and the RNase H enzyme for screening antiviral agents.Type: GrantFiled: January 11, 1999Date of Patent: June 6, 2000Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung-June Yoon, Jong-Woo Kim, Yong Huh, Hyune-Mo Rho, Gu-Hung Jung
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Patent number: 5968781Abstract: The present invention relates to hepatitis B virus (hereinafter it refers to HBV) polymerase containing a histidine tag, RNase H enzyme derived from HBV polymerase and processes for preparation thereof.More particularly, the present invention relates to recombinant HBV polymerase, its RNase H domain with enzyme activity, expression vectors producing the enzymes in E. coli and processes for preparing the HBV polymerase and the RNase H enzyme which can be easily purified due to their histidine tags.And the present invention relates to uses of the HBV polymerase and the RNase H enzyme for screening antiviral agents.Type: GrantFiled: August 15, 1997Date of Patent: October 19, 1999Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung-June Yoon, Jong-Woo Kim, Yong Huh, Hyune-Mo Rho, Gu-Hung Jung
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Patent number: 5932742Abstract: The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which - -, R.sub.1, and R.sub.2 are as defined in the specification.Type: GrantFiled: December 16, 1998Date of Patent: August 3, 1999Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung June Yoon, Yong Ho Chung, Moon Sun Lee, Dong Rack Choi, Jung A Lee, Hee Soon Lee, Hae Ran Yun, Dug Keun Lee, Eun Yi Moon, Hyun Sook Hwang, Chung Ha Choi, Sang Hun Jung
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Patent number: 5929103Abstract: The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which ----, R.sub.1, and R.sub.2 are as defined in the specification.Type: GrantFiled: August 21, 1997Date of Patent: July 27, 1999Assignee: Dong Wha Pharm. Ind. Co., Ltd.Inventors: Sung June Yoon, Yong Ho Chung, Moon Sun Lee, Dong Rack Choi, Jung A Lee, Hee Soon Lee, Hae Ran Yun, Dug Keun Lee, Eun Yi Moon, Hyun Sook Hwang, Chung Ha Choi, Sang Hun Jung