Abstract: A headache therapeutic instrument is provided, which includes a wearable frame adapted to fit on a human head, massage and transdermal medicine permeation devices, liquid medicine delivery tubes, a liquid medicine delivery device and a liquid medicine storage box. The wearable frame is provided with at least one acupoint locating hole adapted to correspond to acupoints along the human head. The massage and transdermal medicine permeation devices are mounted on the wearable frame and correspond to the acupoint locating hole. The liquid medicine delivery device delivers medicines in the liquid medicine storage box to the massage and transdermal medicine permeation devices through the liquid medicine delivery tubes. The massage and transdermal medicine permeation devices can conduct medicine permeation and massage on corresponding acupoints.