Abstract: A thermotherapy device for treatment of diseased biological tissues. The thermotherapy device includes a primary and at least one secondary cooling and/or radiation shielding lumen. The lumens are connected or disposed adjacent one another along their longitudinal exterior walls. An energy source is insertable into one or more of the cooling lumens to carry out a heating protocol to treat the diseased tissue while screening and/or cooling normal tissue. A transrectal ultrasound positioning and temperature sensing device can control the energy source for effective treatment.